Clinical trials
Anal Canal Cancer clinical trials
Below are recruiting anal canal cancer clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06630793Recruiting
Comparing types of radiation for anal cancer
This study compares standard radiation (IMRT) with a newer, more precise type (IMPT) both given alongside chemotherapy for anal cancer. It aims to see which is better at controlling cancer and reducing side effects.
Mumbai, MaharashtraAges 18–80 - NCT05040815RecruitingPhase 2
Sparing inner groin nodes during early anal cancer radiation
This trial tests whether a specific radiation plan that avoids treating the inner groin lymph nodes can treat early-stage anal cancer effectively while reducing side effects. Participants may also receive chemotherapy if they are eligible.
Edmonton, AlbertaAges 18 years+ - NCT06471296Recruiting
How viruses affect tumors and treatment
This study looks at how viruses change the environment around tumors, especially in cancers of the throat, lung, lymph nodes, and anal canal. It aims to understand why some treatments work better for virus-related cancers than others.
ParisAges 18–100 - NCT06640283RecruitingPhase 2
Circulating tumor DNA monitoring for cervical and anal cancer
This trial uses a blood test to track tumor DNA in patients with HPV-related cervical or anal cancer. It aims to see if this test can detect early signs of recurrence after radiation therapy, helping guide follow-up care.
São PauloAges 18 years+ - NCT06837831Recruiting
Mepilex Lite Dressing for radiation skin damage on anal area
This trial tests a special wound dressing (Mepilex Lite) to treat skin burns from radiation therapy in patients with rectal cancer. It may help heal the skin around the anal canal more comfortably.
Jinan, ShandongAges 18 years+ - NCT02185443RecruitingPhase 2
SBRT radiation for liver metastases that can’t be surgically removed
This trial studies stereotactic body radiation therapy (high-precision radiation given in a few sessions) for liver metastases when surgery isn’t possible. It may help shrink or control tumors in the liver and delay progression in people whose cancer has not spread outside the liver (or only to areas treated with a curative plan).
São Paulo, São PauloAges 18 years+ - NCT07425054RecruitingPhase 2
Chemoradiation with or without immunotherapy for anal cancer
This trial tests whether adding an immunotherapy drug (retifanlimab) to standard chemoradiation improves outcomes for people with locally advanced anal cancer. The treatment is adjusted based on HPV DNA levels in your blood.
Cleveland, OhioAges 18 years+ - NCT04221893Recruiting
Radiation therapy for metastatic gastrointestinal cancers
This trial tests whether adding radiation therapy to your current immunotherapy can help control cancer that has spread in the digestive system. It aims to improve symptoms and possibly slow the cancer's growth.
San Francisco, CaliforniaAges 18 years+ - NCT04429542RecruitingPhase 1
Test of an EGFR-targeting drug for advanced solid cancers
This Phase 1 study tests the safety of BCA101 (an EGFR-targeting treatment) alone or combined with pembrolizumab. It may help people with certain EGFR-driven advanced cancers, depending on the tumor type, prior treatments, and required biopsy testing.
La Jolla, CaliforniaAges 18 years+ - NCT07555678RecruitingPhase 2
Chemotherapy, radiation, and immunotherapy for anal cancer
This study tests a combination of chemotherapy, radiation therapy, and an immunotherapy drug (anti-PD-1 antibody) for anal squamous cell cancer. The trial enrolls patients at different stages of disease to see if adding immunotherapy improves outcomes.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06364579Recruiting
Measuring quality of life in anal cancer radiotherapy
This trial studies how patients feel during and after radiation therapy for anal cancer. It uses questionnaires to understand symptoms and well-being, helping doctors improve care.
Rome, LazioAges 18 years+ - NCT05838391Recruiting
Targeted radiation approach for anal cancer
This trial tests an adaptive, image-guided radiation plan for anal canal squamous-type cancers. It may help deliver effective treatment while adjusting the radiation based on how your body and tumor respond.
New York, New YorkAges 18 years+ - NCT05661188RecruitingPhase 2
Tiraglolumab plus atezolizumab with chemoradiation for anal cancer
This Phase 2 trial tests whether adding tiraglolumab and atezolizumab to standard chemoradiation can improve outcomes for people with localized anal canal squamous cell cancer that has not spread to distant organs. It may help the immune system work better alongside treatment to control the cancer.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT04462042Recruiting
Proton vs photon radiation for anal canal cancer
This study compares two types of radiation—protons versus photons—for anal canal squamous cell carcinoma. It may help find which option delivers treatment more effectively or with fewer side effects.
GothenburgAges 18 years+ - NCT07692152RecruitingPhase 3
Immunotherapy vs. chemo for MS anal cancer trial
This trial tests sintilimab (a type of immunotherapy) against mitomycin plus chemotherapy with radiation for anal cancer that hasn't spread. It aims to find a better treatment with fewer side effects.
Beijing, Beijing MunicipalityAges 18–75
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Common questions
- Are there clinical trials for anal canal cancer?
- Yes. Clin2 currently lists 15 recruiting anal canal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anal canal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anal canal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.