Clinical trials
Anhedonia clinical trials
Below are recruiting anhedonia clinical trials, each written for real people, not researchers. We’re tracking 34 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07476469Recruiting
Nerve stimulation for anhedonia and anxiety
This study tests whether a gentle nerve stimulation device (tVNS) placed on your ear can help reduce symptoms of anhedonia (loss of pleasure) and anxiety. You will also have brain scans (MRI) to see how the treatment affects your brain.
BonnAges 18–40 - NCT07040449Recruiting
Stress and pleasure study for young teens
This study looks at how stress affects mood and the brain in teenagers aged 13 to 15. It involves brain scans and other tests to better understand teen mental health.
Chapel Hill, North CarolinaAges 13–15 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT06075771RecruitingPhase 4
Testing a Parkinson's drug for depression-related loss of interest
This trial tests whether a medication used for Parkinson's disease (carbidopa-levodopa) can help people with major depression who have lost interest or pleasure in things. It is for adults who have not been helped enough by other treatments and have signs of inflammation.
Atlanta, GeorgiaAges 25–55 - NCT07155941Recruiting
App-based training for lack of pleasure
This trial tests if an app-based training program can help people who have trouble feeling pleasure from daily activities (anhedonia). It combines mood check-ins and simple, repeated exercises to retrain the brain's reward system.
Marburg, HesseAges 18 years+ - NCT07637773Recruiting
Brain Stimulation for Depression and Loss of Interest in Older Adults
This trial tests a new brain stimulation technique called tACS (transcranial alternating current stimulation) to treat depression in people aged 60 and older, especially the symptom of losing interest in things you once enjoyed. Researchers believe this targeted stimulation may help improve mood and motivation.
Tianjin, Tianjin MunicipalityAges 60 years+ - NCT07348666Recruiting
Smartphone safety planning for teens at risk
This trial tests a smartphone-based safety planning tool that gives you support right when you need it. It's designed for teens and young adults who are at risk for suicide and are already getting care at participating clinics.
Eugene, OregonAges 13–24 - NCT05691439Recruiting
Sleep Timing, Mood, and Brain Circuits in Teens With Depression
This study looks at how sleep timing affects brain function related to mood and “pleasure” in teenagers who have depressive symptoms. It may help researchers understand why depression and reduced interest/pleasure can happen, and how sleep patterns might be a key factor.
Eugene, OregonAges 14–18 - NCT05282277RecruitingPhase 4
Estradiol to improve brain and reward changes in midlife women
This study tests whether a hormone called estradiol (given as a patch and pill) changes how the brain and body respond to reward in some midlife women with low pleasure and/or psychosis symptoms during menopause transition. It may help researchers understand whether estrogen treatment can improve mood-related “reward” function in this group.
Chapel Hill, North CarolinaAges 45–55 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05384158Recruiting
Testing a computer game for low mood, low pleasure, or anxiety
This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.
Roanoke, VirginiaAges 25–50 - NCT05617898Recruiting
Study how social rewards work in early schizophrenia
This study looks at how your brain learns from positive social experiences in people who are in the early stages of schizophrenia-type illness. It may help researchers understand “social anhedonia” (feeling less pleasure or reward from social situations) and guide future treatments.
Birmingham, AlabamaAges 18–35 - NCT05849038RecruitingPhase 2
Treating inflammation to improve depression in HIV
This Phase 2 study looks at whether lowering inflammation can help improve depression symptoms in adults living with HIV. You may be able to join if your HIV is well controlled and you are currently experiencing major depression (or a certain type of bipolar depression).
Atlanta, GeorgiaAges 18–65 - NCT05920252Recruiting
Phone-based suicide risk support for teens in DBT
This trial tests whether a smartphone tool can help reduce suicide risk for teens who are already in an intensive therapy program (DBT). It may help you or your family recognize risk earlier and use skills more consistently between sessions.
New York, New YorkAges 13–18 - NCT05991713Recruiting
GPS and brain study for healthy volunteers
This study uses a smartphone GPS app and brain scans (fMRI) to understand how daily emotions and movement patterns are connected. It may help researchers learn more about how people's environments affect their feelings.
Coral Gables, FloridaAges 18–50 - NCT06080646Recruiting
Depression and Reward Processing Brain Study
This study uses brain scans (MRI) to understand how people with depression process rewards, aiming to identify different depression subtypes. You may join if you have depression or if you are a healthy volunteer.
San Francisco, CaliforniaAges 18–70 - NCT06096740Recruiting
Talking therapy for PTSD and its effects on the brain
This study looks at how a specific type of talk therapy affects the way your brain processes rewards. You'd join a group that either starts therapy right away or waits a bit before starting. Your brain activity will be scanned with an MRI to see changes.
Austin, TexasAges 18–65 - NCT06132581Recruiting
Brain stimulation for pleasure loss in depression
This study tests a new type of brain stimulation to see if it can help people with depression who have lost the ability to feel pleasure. It uses MRI scans to guide the treatment and may help improve motivation and goal-setting.
Tallahassee, FloridaAges 18–65 - NCT06364488Recruiting
App for monitoring depression and anxiety in pregnancy
This trial tests a mobile app called TrueBlue to help monitor depression and anxiety in new and expecting mothers. If you are pregnant or recently gave birth, the study will see if the app can make tracking your moods easier and connect you with care.
Nottingham, NottinghamshireAges 18 years+ - NCT07671131Recruiting
Chatbot for helping people who feel little pleasure or joy
This trial tests if a chatbot can improve emotional responses for people with anhedonia (reduced ability to feel pleasure). You will interact with the chatbot and may have brain scans to see changes.
Chengdu, SichuanAges 18–40 - NCT07665242Recruiting
Chatbot therapy for anhedonia and depression
This study tests whether a chatbot-based therapy can help people who feel low pleasure or interest (anhedonia) and depression. It uses brain scans to see how the brain responds to rewards and social situations.
Chengdu, SichuanAges 18–40 - NCT07663019Recruiting
Can a chatbot help with anhedonia and depression?
This study tests whether a friendly chatbot can help people with anhedonia (loss of pleasure) and depression update their beliefs in a more positive way. You'll interact with the chatbot and may have an MRI scan to see how your brain responds.
Chengdu, SichuanAges 18–40 - NCT07665216Recruiting
Chatbot for anhedonia and depression
This study tests whether a chatbot-based intervention can improve brain function and reduce symptoms in people who feel very little pleasure or interest (anhedonia) and have depression. You would have MRI scans to see how your brain responds.
Chengdu, SichuanAges 18–40 - NCT06610305RecruitingPhase 4
Hormones, mood, and reward in women with PMS-related depression
This study looks at how changes in hormone levels during the menstrual cycle affect mood and the brain's reward system in women with depression that gets worse before their period. The goal is to understand why this happens so better treatments can be developed.
Chapel Hill, North CarolinaAges 18–45
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Anhedonia trials by city
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Anhedonia trials by state
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Common questions
- Are there clinical trials for anhedonia?
- Yes. Clin2 currently lists 34 recruiting anhedonia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anhedonia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anhedonia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.