Clinical trials
Anhedonia clinical trials
Below are recruiting anhedonia clinical trials, each written for real people, not researchers. We’re tracking 36 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07476469Recruiting
Nerve stimulation for anhedonia and anxiety
This study tests whether a gentle nerve stimulation device (tVNS) placed on your ear can help reduce symptoms of anhedonia (loss of pleasure) and anxiety. You will also have brain scans (MRI) to see how the treatment affects your brain.
BonnAges 18–40 - NCT07813169Recruiting
Brain stimulation for loss of pleasure in depression
This study tests a type of brain stimulation called iTBS (repetitive magnetic pulses) to see if it can help people with depression who feel little pleasure in life. The treatment targets a brain area involved in reward, and may improve your mood and ability to enjoy things.
Changsha, HunanAges 18–45 - NCT07803185Recruiting
Emotional eating and anhedonia with weight loss medications
This study looks at how GLP-1 weight loss medications affect emotional eating (eating in response to feelings) and anhedonia (loss of interest or pleasure). If you're starting one of these drugs for weight loss, your participation may help understand these side effects.
Kayseri, MelikgaziAges 18 years+ - NCT07637773Recruiting
Brain Stimulation for Depression and Loss of Interest in Older Adults
This trial tests a new brain stimulation technique called tACS (transcranial alternating current stimulation) to treat depression in people aged 60 and older, especially the symptom of losing interest in things you once enjoyed. Researchers believe this targeted stimulation may help improve mood and motivation.
Tianjin, Tianjin MunicipalityAges 60 years+ - NCT07607938RecruitingPhase 1
Psilocybin for Depression With Loss of Interest or Pleasure
This study tests whether psilocybin, a naturally occurring psychedelic compound, can help people with depression who experience anhedonia—a loss of interest or pleasure in activities. Researchers will monitor your brain activity and mood changes over time to see if this treatment is safe and helpful.
New York, New YorkAges 18–65 - NCT07155941Recruiting
App-based training for lack of pleasure
This trial tests if an app-based training program can help people who have trouble feeling pleasure from daily activities (anhedonia). It combines mood check-ins and simple, repeated exercises to retrain the brain's reward system.
Marburg, HesseAges 18 years+ - NCT07040449Recruiting
Stress and pleasure study for young teens
This study looks at how stress affects mood and the brain in teenagers aged 13 to 15. It involves brain scans and other tests to better understand teen mental health.
Chapel Hill, North CarolinaAges 13–15 - NCT06075771RecruitingPhase 4
Testing a Parkinson's drug for depression-related loss of interest
This trial tests whether a medication used for Parkinson's disease (carbidopa-levodopa) can help people with major depression who have lost interest or pleasure in things. It is for adults who have not been helped enough by other treatments and have signs of inflammation.
Atlanta, GeorgiaAges 25–55 - NCT05240352Recruiting
Personalized brain stimulation help for bipolar depression anhedonia
This study looks at using brain scans to better tailor transcranial direct current stimulation (a noninvasive brain stimulation) for people with bipolar depression who feel little pleasure. It aims to see whether matching the stimulation to your brain signals can improve symptoms like anhedonia.
Houston, TexasAges 18–50 - NCT07825285Enrolling by invitation
Training positive emotions for teens with low mood
This study tests a simple training to help teenagers with mild to moderate depression focus on positive events and boost positive emotions. It's a short, supportive program that might help you feel better day by day.
LeuvenAges 12–16 - NCT07665242Recruiting
Chatbot therapy for anhedonia and depression
This study tests whether a chatbot-based therapy can help people who feel low pleasure or interest (anhedonia) and depression. It uses brain scans to see how the brain responds to rewards and social situations.
Chengdu, SichuanAges 18–40 - NCT07665216Recruiting
Chatbot for anhedonia and depression
This study tests whether a chatbot-based intervention can improve brain function and reduce symptoms in people who feel very little pleasure or interest (anhedonia) and have depression. You would have MRI scans to see how your brain responds.
Chengdu, SichuanAges 18–40 - NCT07671131Recruiting
Chatbot for helping people who feel little pleasure or joy
This trial tests if a chatbot can improve emotional responses for people with anhedonia (reduced ability to feel pleasure). You will interact with the chatbot and may have brain scans to see changes.
Chengdu, SichuanAges 18–40 - NCT07661901Recruiting
Reward sensitivity app for teens with suicidal thoughts
This trial tests a smartphone-based program designed to help teens who have had recent thoughts of suicide. It aims to see if the app can reduce suicide risk by boosting sensitivity to rewards in daily life.
Philadelphia, PennsylvaniaAges 13–17 - NCT07663019Recruiting
Can a chatbot help with anhedonia and depression?
This study tests whether a friendly chatbot can help people with anhedonia (loss of pleasure) and depression update their beliefs in a more positive way. You'll interact with the chatbot and may have an MRI scan to see how your brain responds.
Chengdu, SichuanAges 18–40 - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07386730RecruitingPhase 1
Psychedelic therapy study for older adults with low well-being
This study tests if a single dose of psilocybin (a psychedelic) or dextromethorphan (a cough suppressant) can improve well-being in healthy older adults who feel their well-being is below average. It aims to understand how these drugs might help boost mood and life satisfaction.
San Francisco, CaliforniaAges 50–85 - NCT07348666Recruiting
Smartphone safety planning for teens at risk
This trial tests a smartphone-based safety planning tool that gives you support right when you need it. It's designed for teens and young adults who are at risk for suicide and are already getting care at participating clinics.
Eugene, OregonAges 13–24 - NCT07319143Recruiting
Can brain stimulation boost emotional health?
This trial uses a gentle brain stimulation technique called tDCS to see if it can improve emotional well-being. It is for healthy young adults who speak Cantonese or Mandarin.
Hong KongAges 18–35 - NCT07146503Recruiting
Esketamine Nasal Spray for Treatment-Resistant Depression in Real Life
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
Genova, GeAges 18–74 - NCT07078227Recruiting
Long-term depression follow-up study
This study follows up with people who took part in an earlier research project on depression and genetics. The goal is to see how depression changes over time.
LundAges 18 years+ - NCT06982820Recruiting
Brain training therapy for depression with loss of interest
This trial tests a new type of brain training (self-neuromodulation) to help people with major depression who also have a significant loss of interest or pleasure (anhedonia). If you qualify, you may get a non-invasive treatment that uses real-time brain feedback to improve symptoms.
Providence, Rhode IslandAges 22–75 - NCT06829953Recruiting
App-based study for teens with depression
This study is testing whether a smartphone app can help teens who feel depressed and have lost interest in things. It's looking for youth aged 12–18 with moderate to severe depression who are willing to use the app.
Philadelphia, PennsylvaniaAges 12–18 - NCT06776991Recruiting
Social anxiety and public speaking fear study
This study tests if reward processing training combined with exposure therapy helps people with social anxiety disorder who are afraid of public speaking. Participants will complete therapy sessions and possibly an MRI brain scan.
Los Angeles, CaliforniaAges 18–60
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Anhedonia trials by city
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Anhedonia trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for anhedonia?
- Yes. Clin2 currently lists 36 recruiting anhedonia studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a anhedonia trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a anhedonia trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.