Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03957343Recruiting
Parkwood Pacing and Planning app for concussion recovery
This study tests a smartphone or tablet app (the Parkwood Pacing and Planning app) that may help people after a mild concussion manage recovery. You may be able to join if you’re an adult, can use the app device, and have a confirmed mild concussion.
London, OntarioAges 18 years+ - NCT03958240Recruiting
Study how cancers trigger the immune system
This study looks at what makes some cancers more “noticeable” to the immune system. It may help researchers design better future immunotherapy by collecting information (often including blood samples) from people with different cancers.
ToulouseAges 18 years+ - NCT03984643Recruiting
Testing computer planning for DBS surgery in essential tremor
This study looks at computer “planning algorithms” for DBS surgery in people with essential tremor whose medication hasn’t helped enough. It may help doctors program the DBS system more accurately for better tremor control.
Minneapolis, MinnesotaAges 21 years+ - NCT03990909Recruiting
BCAA supplements to help improve sleep
This pilot study tests whether taking BCAA supplements can improve sleep problems. You may be able to join if you’re a veteran with sleep issues and can do the study by phone.
Portland, OregonAges 18–89 - NCT04004169Recruiting
Closed-loop deep brain stimulation for long-lasting depression
This study tests a special kind of brain stimulation that can adjust to your brain signals while treating major depression that has not improved with standard treatments. It may help people with severe, long-term treatment-resistant depression, but it requires brain surgery and frequent visits.
San Francisco, CaliforniaAges 22–70 - NCT06580002RecruitingPhase 2
Can Riluzole Help with Chemo Brain? A Pilot Study
This study tests if a medicine called riluzole (currently used for ALS) can help with 'chemo brain' – memory and thinking problems after cancer treatment. It is for people who feel their mental sharpness has declined after breast cancer therapy, certain chemotherapies, or brain radiation.
Orange, CaliforniaAges 18 years+ - NCT07703722RecruitingPhase 3
Psilocybin and therapy for depression with trauma
This trial tests psilocybin (a compound from certain mushrooms) combined with a structured therapy to see if it helps people with depression linked to trauma. It focuses on how the treatment affects the connection between the gut and brain.
Islamabad, CapitalAges 18–60 - NCT07700862Recruiting
Deep brain stimulation for tremor-dominant Parkinson's disease
This trial compares two ways to place electrodes in the brain to reduce tremors. It may help people with Parkinson's disease whose main symptom is shaking.
ShanghaiAges 18–80 - NCT07703761Recruiting
AI analysis of brain tumor MRI scans
This trial uses artificial intelligence to analyze MRI scans from people diagnosed with a type of brain tumor called glioma. It aims to better understand the cancer from diagnosis through treatment, which could help guide future care.
TrentoAges 18–60 - NCT05989893Recruiting
Mapping human thinking during brain surgery
This study maps how thinking works in people with epilepsy or brain lesions near important brain areas. It involves testing during brain surgery procedures to help researchers understand healthy brain function.
Houston, TexasAges 18–75 - NCT05854433Enrolling by invitation
Study brain structure in adults with muscle weakness
This study uses scans and other tests to understand how brain structure relates to symptoms in people with myotonic dystrophy type 1 or type 2. It may help researchers connect measurable brain changes to movement and other clinical outcomes.
Winston-Salem, North CarolinaAges 30–65 - NCT04012411Recruiting
Testing brain fluid biomarkers in Huntington’s disease
This study looks at specific “biomarkers” (measurable signs) found in cerebrospinal fluid, to better understand Huntington’s disease. The results may help researchers track the disease and improve future tests or treatments.
MontpellierAges 18 years+ - NCT04030507Recruiting
Brain MRI screening during chemotherapy for breast cancer
This trial checks the brain using MRI in people with breast cancer that has spread outside the breast or can’t be fully removed. The goal is to screen for brain involvement and see how MRI findings fit with treatment timing, when it’s safe to do so.
Boston, MassachusettsAges 18 years+ - NCT04033679Recruiting
Brain stimulation to help people stay on schizophrenia medications
This study tests whether a non-invasive brain stimulation treatment can improve medication adherence in people with schizophrenia or schizoaffective disorder. If it helps you take meds more reliably, it may also support more stable mental health over time.
Toronto, OntarioAges 18 years+ - NCT04038840RecruitingPhase 1
Brain PET-MR imaging to study schizophrenia connections
This early (Phase 1) study uses a special brain scan to look at synapses—the contact points between brain cells—in people with schizophrenia-related conditions. It helps researchers understand brain activity and connection patterns, which may guide future tests or treatments.
Palo Alto, CaliforniaAges 18–65 - NCT04047264Recruiting
Testing a brain fluid sampling technique during brain surgery
This study tests whether taking tiny samples of brain fluid during brain tumor or epilepsy surgery is safe and practical. If it works well, it may help doctors better understand brain tissue during surgery.
Rochester, MinnesotaAges 18 years+ - NCT04061135Recruiting
Study brain and movement patterns in Parkinson’s or tremor
This study looks at brain signals, thinking, and movement behaviors in people who have Parkinson’s disease or essential tremor and are being considered for deep brain stimulation (DBS) surgery. It may help researchers better understand how DBS affects the brain and day-to-day function.
Birmingham, AlabamaAges 18 years+ - NCT04066465Recruiting
Testing how proton therapy affects thinking in young people
This study looks at how proton radiation therapy may affect thinking, learning, and brain function in children and teens with a primary brain tumor. It uses repeated short brain/learning tests to track possible changes over time.
Dresden, SaxonyAges 8–18 - NCT04071847Recruiting
Study tracking results after Abbott deep brain stimulator surgery
This study follows people who are getting a new Abbott deep brain stimulator (DBS) device or replacing the battery/implantable pulse generator to see how outcomes change over time. It mainly applies to certain DBS targets and diagnoses, and it uses follow-up visits to track results.
Tucson, ArizonaAges Any age - NCT04099823Recruiting
MRI study of spinal fluid flow in memory or balance problems
This study uses MRI to look at how spinal fluid moves inside and around the brain. It aims to better understand conditions that can affect thinking, memory, balance, and coordination—such as normal pressure hydrocephalus—or compare with healthy people.
Rochester, MinnesotaAges 18 years+ - NCT04099797RecruitingPhase 1
CAR T therapy for certain GD2 brain tumors
This Phase 1 study tests CAR T cells designed to target a marker called GD2 on brain tumors. It aims to see if the treatment is safe and whether it can shrink or control these tumors in children and young adults.
Houston, TexasAges 1–25 - NCT04115254Recruiting
MRI-guided focused radiation for certain tumors
This study tests a type of high-precision radiation guided by MRI pictures to treat certain cancers. It may help doctors deliver radiation more accurately while avoiding nearby healthy tissue, but you must be able to safely complete an MRI scan and meet tumor-size and health requirements.
Boston, MassachusettsAges 18 years+ - NCT04116996Recruiting
Brain stimulation for severe insomnia in Parkinson’s
This trial tests whether stimulating a specific brain area (the globus pallidus) can improve severe insomnia in people who also have Parkinson’s symptoms. You might be considered if your insomnia is very difficult to control and you meet the study’s brain, sleep, and travel requirements.
Jacksonville, FloridaAges 40–80 - NCT04132362Recruiting
Personalized music program for people with dementia in care homes
This feasibility study tests whether a personalized music listening program in care homes is practical and acceptable. It may help people with dementia by using familiar, chosen music and collecting feedback on how they respond.
Harpenden, HertfordshireAges Any age
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Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.