Clinical trials
Brain clinical trials
Below are recruiting brain clinical trials, each written for real people, not researchers. We’re tracking 2,059 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03324360RecruitingPhase 1
MRI scan test in people with brain metastases after SRS
This early-phase study tests a special MRI scan using a safe tracer to see how brain metastases and brain metabolism change after SRS (a focused radiation treatment). It may help researchers find better ways to monitor treatment response in the brain.
Toronto, OntarioAges 18 years+ - NCT03340129RecruitingPhase 2
Nivolumab plus focused brain radiation for melanoma spread
This trial studies whether giving the immunotherapy drug nivolumab together with targeted brain radiation (not whole-brain radiation) helps people with melanoma that has spread to the brain. It aims to improve brain control while keeping side effects manageable.
Sydney, New South WalesAges 18–120 - NCT03371641Recruiting
Study of alcohol exposure effects in unborn babies
This study looks at unborn babies exposed to alcohol during pregnancy and compares them with babies not exposed. Researchers test a pregnancy blood marker to see whether it may relate to early brain changes in the baby.
RouenAges 18 years+ - NCT03418441Recruiting
Study infections of the brain and spinal fluid in Denmark
This trial focuses on people in Denmark who may have an infection in the brain or the fluid around the brain and spinal cord. Researchers aim to collect and compare diagnostic results for different infection types (viral meningitis, bacterial meningitis, encephalitis, and others) to help confirm the cause and guide care.
AalborgAges 18 years+ - NCT03418961RecruitingPhase 3
Study of heart-risk management for metastatic HER2 breast cancer
This trial follows people with metastatic HER2-positive breast cancer who are at higher risk for heart damage while on HER2-targeted therapy. Some participants are randomly assigned to different monitoring/heart-protection approaches to see what best helps keep the heart safe.
Anchorage, AlaskaAges 18 years+ - NCT03437928Recruiting
Deep brain stimulation for severe, treatment-resistant depression
This trial tests whether deep brain stimulation (DBS, a surgically placed device that sends signals to the brain) can reduce symptoms of long-lasting major depression that has not improved with many treatments. You may be more likely to qualify if your depression has been present for years, has been resistant to multiple medications and therapies, and if you meet specific safety and testing requirements.
Dallas, TexasAges 22–70 - NCT03526822Recruiting
Study of new glioblastoma using MRI scans and lab markers
This study follows people newly diagnosed with glioblastoma to see how certain lab signals (MMP2 and MMP9) match up with MRI scan features. It may help doctors better understand the disease and how it appears on imaging, but it’s mainly observational.
MarseilleAges 18 years+ - NCT03534050RecruitingPhase 2/Phase 3
Testing new radiotherapy outcomes after low-grade brain tumor surgery
This trial studies how patients with grade 2 or 3 low-grade brain gliomas do after modern radiotherapy following surgery (or biopsy). It looks at both brain/memory functioning and cancer outcomes, especially for people at higher risk from their surgery or age.
TaoyuanAges 20–84 - NCT03563729RecruitingPhase 2
Melanoma in the brain: steroids plus targeted therapy
This Phase 2 trial studies how giving steroid medicine for brain swelling may help people with melanoma that has spread to the brain, and whether adding a targeted approach works for a specific genetic tumor type. It may help shrink brain tumors and improve symptoms, while comparing how patients respond.
Herlev, Capital RegionAges 18 years+ - NCT03578003Recruiting
Bright morning light to improve sleep in veterans
This study tests whether using bright morning light can improve sleep quality in veterans. You may be able to join if you’re not already using a light box and you don’t have certain eye or mood conditions.
Portand, OregonAges 18 years+ - NCT03678194Recruiting
Smartphone app tool for doctors managing daily depression
This trial tests a smartphone app that helps doctors manage depression in everyday life. It may help improve how care is tracked and adjusted soon after starting antidepressant treatment.
BordeauxAges 18–65 - NCT03694626Recruiting
Test a light-response study to measure and track light sensitivity
This study aims to objectively measure how your pupils respond to light and how your eye muscles react using recording tests. It may help confirm the cause of light sensitivity (especially after a brain injury) and better track how it responds to care.
Iowa City, IowaAges 18–80 - NCT03696680RecruitingPhase 2
Stereotactic radiation for brain metastases that recently bled
This trial tests a precise type of radiation aimed at brain metastases that show signs of recent bleeding. It aims to control the tumors while reducing risks, especially compared with the usual approach for patients who have bleeding signals in the brain lesions.
AvranchesAges 18 years+ - NCT03728673RecruitingPhase 2
Escitalopram for people with newly diagnosed grade 4 brain tumors
This trial studies whether escitalopram (an antidepressant medication) can help people with grade 4 glioma around the time they start standard cancer treatment. You may be screened especially for depression/anxiety status and medication history, because the study uses a specific mental-health medicine.
Omaha, NebraskaAges 19 years+ - NCT03819608Recruiting
Brain stimulation and rehab after mild concussion with PTSD or cognitive issues
This trial studies whether brain stimulation plus targeted brain rehabilitation can improve symptoms after a mild concussion (mTBI). You may be invited if your concussion happened at least 3 months ago and your symptoms are affecting thinking or mood, with or without PTSD.
Chicago, IllinoisAges 18–80 - NCT03819738Recruiting
Brain scan during deep brain stimulation
This study checks how brain imaging works in people who already have a deep brain stimulation (DBS) device. If you have a DBS system, the study may help researchers better understand what the stimulation is doing in the brain.
Leuven, Vlaams-BrabantAges 18 years+ - NCT03832712Recruiting
Study for adults with essential tremor not helped by beta blockers
This trial looks at people with essential tremor (a shaking condition) whose usual medicine—beta blockers—didn’t work well or couldn’t be tolerated. The goal is to test a treatment approach that may improve tremor control and daily function.
GothenburgAges 18–75 - NCT03849430Recruiting
Quality-of-life study for adults with glioma
This study looks at how your quality of life changes over time after being diagnosed with a brain tumor called glioma. It may help doctors better understand what support or treatments improve day-to-day well-being.
Leuven, Vlaams-BrabantAges 18 years+ - NCT03851523Recruiting
Tracking memory changes in people with early Alzheimer’s symptoms
This study follows people over time to better understand how memory and thinking complaints progress in early Alzheimer’s disease (from “subjective cognitive decline” to mild cognitive problems). It may help researchers understand who is likely to decline and how symptoms change, which could support future treatments.
Barcelona, CataloniaAges 45 years+ - NCT03857529Recruiting
Rehab training for stroke arm control using brain and hand stimulation
This study tests whether non-invasive brain stimulation plus a hand/arm electrical stimulation device can improve how well your stroke-affected arm and hand move during therapy tasks. You would take part in screening and then receive these combined rehab approaches to see if motor control improves.
Cleveland, OhioAges 21 years+ - NCT03910010Recruiting
Brain scan study to study pain-related body signals in fibromyalgia
This study uses MRI brain scans to look for body “signals” (biomarkers) that may relate to chronic pain, including fibromyalgia. It may help researchers better understand what’s going on in the brain for people with long-term pain.
Halifax, Nova ScotiaAges 18–75 - NCT03936647Recruiting
Testing a WEB device inside brain aneurysms
This trial studies whether placing a WEB device inside certain brain aneurysms can control the aneurysm and reduce risk. You might be considered if your aneurysm fits size and severity limits and your doctor thinks the WEB approach is appropriate.
Edmonton, AlbertaAges 18 years+ - NCT03952637RecruitingPhase 1/Phase 2
Gene therapy for GM1 disease with IV delivery
This early-stage study tests an IV gene therapy that delivers a working copy of an enzyme gene to help the body make beta-galactosidase in GM1 gangliosidosis. It may help slow or improve disease symptoms and looks closely at safety and how well the treatment works.
Bethesda, MarylandAges 6 months–12 years - NCT03954899Recruiting
Melatonin test for brain health in older adults
This study tests whether taking 5 mg of melatonin can improve thinking and brain health over time in older adults with early, mild symptoms. You may help researchers learn which brain changes and measures improve with melatonin.
Iowa City, IowaAges 56–85
Hear when a new Brain trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for brain?
- Yes. Clin2 currently lists 2,059 recruiting brain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a brain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a brain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.