Clinical trials
Breast Cancer Stage I clinical trials
Below are recruiting breast cancer stage i clinical trials, each written for real people, not researchers. We’re tracking 1,197 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06610565Recruiting
Fasting-mimicking diet for breast cancer side effects
This study tests if a special diet that mimics fasting can help reduce side effects from hormone therapy (aromatase inhibitors) in women with breast cancer. The diet is a low-calorie meal plan designed to lower cholesterol and improve well-being.
Milan, ItalyAges 18 years+ - NCT06611813RecruitingPhase 2
Chemo plus immunotherapy for HR+/HER2- breast cancer
This trial tests whether adding an immunotherapy drug (toripalimab) to standard chemotherapy before surgery can help treat HR+/HER2- breast cancer. It is for women with early-stage breast cancer that has not spread to other parts of the body.
HangzhouAges 18–75 - NCT06633601RecruitingPhase 1
Ultrasound and microbubbles with radiation for breast cancer
This trial tests a new way to combine radiation therapy with ultrasound and tiny bubbles to treat breast cancer that has spread to the chest wall or is advanced. It aims to make radiation more effective and safer.
Toronto, OntarioAges 18 years+ - NCT06635980RecruitingPhase 2
Radiation before or after breast cancer surgery
This trial compares two ways of giving radiation for breast cancer that has not spread: before or after surgery. It aims to see if giving radiation first might work as well or better.
Scottsdale, ArizonaAges 18 years+ - NCT06637306RecruitingEarly Phase 1
Testing dupilumab with chemo for advanced triple-negative breast cancer
This trial adds dupilumab (a targeted immune treatment) to standard chemotherapy before surgery for patients with advanced triple-negative breast cancer. The goal is to see if this combination helps shrink tumors more effectively.
New York, New YorkAges 18 years+ - NCT06642545RecruitingPhase 2
New targeted drug combo for HER2-low breast cancer
This trial tests a new combination of targeted drugs (Disitamab Vedotin and RC148) against a standard chemotherapy (Abraxane) with or without an immunotherapy drug (Toripalimab) for advanced breast cancer that is HER2-low and hormone receptor-negative. The goal is to see if the new combination works better at shrinking tumors and slowing cancer growth.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06650423Recruiting
Staying on hormone therapy for early breast cancer
This study looks at how well patients take their hormone-lowering pills (aromatase inhibitors, with or without abemaciclib) for early-stage breast cancer. It aims to understand adherence patterns and help improve support for patients.
LjubljanaAges 18–99 - NCT06672120Recruiting
Exercise for triple-negative breast cancer patients
This trial tests whether a structured exercise program can help women with newly diagnosed triple-negative breast cancer who are getting a specific combination of immunotherapy and chemotherapy. The goal is to see if staying active during treatment improves outcomes and well-being.
Munich, BavariaAges 18–65 - NCT06676761Recruiting
Study of a new minimal scar mastectomy
This trial is testing a new surgical technique that leaves a smaller scar during mastectomy for breast cancer. It may be a good option if you want to keep the scar as small as possible.
SingaporeAges Any age - NCT06677879RecruitingPhase 2
Proton vs photon radiation for left-sided breast cancer
This study is comparing two types of radiation therapy—proton therapy and standard photon therapy—for people with left-sided breast cancer who need radiation after surgery. The goal is to find out which method best protects the heart while effectively treating the cancer.
ShanghaiAges 18–80 - NCT06677944RecruitingPhase 2
Radiation before surgery for early-stage breast cancer
This trial tests giving radiation to the tumor area before surgery for women with early-stage, hormone-sensitive breast cancer. The idea is to see if giving radiation first can help protect healthy tissue while still being effective.
SeoulAges 45 years+ - NCT06678269RecruitingPhase 1
Abemaciclib and radiation for metastatic breast cancer
This trial tests whether a targeted therapy (abemaciclib) combined with focused radiation (SBRT) to a bone tumor can help people with advanced breast cancer. It is for patients whose cancer is hormone receptor positive and HER2 negative, and who will continue abemaciclib after radiation.
Basking Ridge, New JerseyAges 18 years+ - NCT06694519Recruiting
Radiofrequency and exercise for pelvic floor issues after breast cancer
This trial tests whether radiofrequency therapy combined with exercise can help with pelvic floor problems like pain, urgency, or incontinence that some women have after breast cancer treatment.
Elche, Spain / ValenciaAges 18 years+ - NCT06697938Recruiting
Chemo plus radiation vs. chemo alone for locally advanced breast cancer
This trial compares two treatments for locally advanced breast cancer: chemotherapy before surgery plus radiation, versus chemotherapy before surgery alone. The goal is to see which approach works better for this specific type of cancer.
Chengdu, SichuanAges 18–70 - NCT06704191RecruitingPhase 1/Phase 2
In-home chemo for bladder cancer trial
This trial tests if you can receive chemotherapy for bladder cancer at home instead of in the clinic. It is for people with early-stage bladder cancer who are already getting certain types of intravesical (inside the bladder) treatment.
Jacksonville, FloridaAges 18 years+ - NCT05941520RecruitingPhase 2
Acolbifene vs low-dose tamoxifen to prevent breast cancer
This Phase 2 trial compares acolbifene and low-dose tamoxifen to see which better lowers breast cancer risk in premenopausal women at high risk. You would be followed with health visits, blood tests, and a breast tissue sampling procedure.
Duarte, CaliforniaAges 35 years+ - NCT04968964Recruiting
Monitoring test for CDK4/6 drugs in metastatic breast cancer
This study follows people with hormone receptor–positive, HER2-negative metastatic breast cancer who are taking CDK4/6 inhibitor treatment (with or without an added blood test called DiviTum®). The goal is to see how well the standard treatment is working and whether DiviTum® (a serum TK1 activity test) can help guide monitoring.
St Louis, MissouriAges 18 years+ - NCT06721065Recruiting
Study of interpretation services for breast cancer patients
This study tests different ways of providing language interpretation during breast cancer or gastrointestinal cancer visits at MSK. It aims to improve communication for patients who prefer Spanish or Mandarin and have limited English proficiency.
Basking Ridge, New JerseyAges 18 years+ - NCT06725940Recruiting
PET scan to check treatment response in breast cancer
This trial uses a special PET scan to see how well your breast cancer is responding to neoadjuvant therapy (treatment given before surgery). The goal is to help doctors personalize your care by checking if the cancer is shrinking.
ShanghaiAges 18–65 - NCT06727773RecruitingPhase 2
Memantine and exercise to protect thinking during chemo for breast cancer
This study tests whether a medicine called memantine combined with a structured exercise program can help protect your thinking and memory during chemotherapy for breast cancer. It may also help understand how these treatments work in the body.
Chapel Hill, North CarolinaAges 18 years+ - NCT06728527Recruiting
Partial breast reconstruction with chest wall flap
This trial tests a specific type of partial breast reconstruction called a chest wall perforator flap. It's for women who previously had a lumpectomy and now want to improve the shape of their breast.
Cambridge, CambridgeshireAges 18 years+ - NCT06729684Recruiting
Digital health program for breast cancer side effects
This study is testing a personalized digital health program to help breast cancer survivors manage side effects. It uses a smartphone app to track symptoms and offer support.
Seoul, Republic of KoreaAges 18–65 - NCT06733350RecruitingPhase 4
Testosterone therapy for low testosterone in men with low-risk prostate cancer
This study tests whether testosterone replacement therapy can safely improve low testosterone levels in men with low-risk prostate cancer who are not getting immediate treatment. It aims to help men feel better without worsening their cancer.
Buffalo, New YorkAges 18 years+ - NCT06738459Recruiting
Matching lymph node tests in breast cancer
This study looks back at past MRI scans and lymph node biopsies or surgeries in people with breast cancer to better understand how cancer spreads to the lymph nodes. If you had these tests as part of your care, your data might help improve future treatment decisions.
VillachAges 18 years+
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Common questions
- Are there clinical trials for breast cancer stage i?
- Yes. Clin2 currently lists 1,197 recruiting breast cancer stage i studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage i trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage i trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage I Breast Cancer AJCC v8
- Early-stage Breast Cancer
- Breast Cancer Stage III
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.