Clinical trials
Breast Cancer Stage III clinical trials
Below are recruiting breast cancer stage iii clinical trials, each written for real people, not researchers. We’re tracking 523 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05741164RecruitingPhase 2
Propranolol plus pembrolizumab for hard-to-treat breast cancer
This Phase 2 trial studies whether adding propranolol to pembrolizumab can “re-sensitize” tumors and slow cancer in triple-negative breast cancer that no longer responds to checkpoint immunotherapy. It may help some people whose cancer has grown despite prior pembrolizumab and chemotherapy.
Atlanta, GeorgiaAges 18 years+ - NCT05780814Recruiting
Treating insomnia to improve weight loss after breast cancer
This study looks at whether improving insomnia (trouble falling asleep or staying asleep) can help survivors of breast cancer lose weight more successfully through a structured behavioral weight loss program. It may help if sleep problems are making it harder to change eating and activity habits.
Washington D.C., District of ColumbiaAges 18 years+ - NCT05795101RecruitingPhase 2
TRUDI trial for inflammatory breast cancer with HER2/low markers
This Phase 2 trial tests two medicines—durvalumab and trastuzumab deruxtecan—to treat stage III inflammatory breast cancer. It may help by controlling cancer growth using treatments aimed at specific breast cancer markers (HER2 positive or “HER2-low”).
Boston, MassachusettsAges 18 years+ - NCT05796973RecruitingPhase 3
Exercise and atorvastatin for metastatic cancer outcomes
This trial tests whether a structured exercise program, along with the cholesterol medicine atorvastatin, can improve outcomes in people with metastatic prostate, breast, ovarian, or kidney cancer. It may help by reducing inflammation and supporting physical function during cancer treatment.
Tampere, Länsi-SuomiAges 18–99 - NCT05837455RecruitingPhase 2
Biomarker-guided treatment for early breast cancer before surgery
This trial looks at whether using tumor test results (biomarkers) can help guide the best hormone treatment and chemotherapy before surgery. It focuses on people with stage II or III, ER-positive, HER2-negative breast cancer, with the goal of improving how well the tumor responds before it is removed.
St Louis, MissouriAges 18 years+ - NCT05866432RecruitingPhase 2
Dato-DXd for triple-negative breast cancer brain metastases
This trial studies Dato-DXd (an antibody-drug medicine) in people with triple-negative breast cancer that has spread to the brain. It aims to see how well it controls brain tumors when they are newly found or growing after other treatments.
Vienna, State of ViennaAges 18–100 - NCT05877859Recruiting
Testing pembrolizumab with chemo before breast cancer surgery
This trial studies whether adding pembrolizumab (an immunotherapy) to standard chemotherapy before surgery improves immune and clinical responses in people with early-stage triple-negative breast cancer. You may benefit by getting a potentially more effective treatment plan, while the study team closely monitors your response.
Atlanta, GeorgiaAges 18 years+ - NCT05896865Recruiting
Personalized breast cancer radiation based on tumor biology
This trial studies whether adjusting radiation dose using how the tumor behaves can improve outcomes for people with locally advanced breast cancer that has spread to certain nearby lymph nodes. It may help deliver the right radiation intensity while avoiding unnecessary exposure.
SeoulAges 19 years+ - NCT05898789Recruiting
Virtual rehab program for cancer survivors
This trial tests a virtual (online) rehabilitation and exercise program for people after breast, colorectal, head and neck, or certain blood cancers. It may help improve recovery and daily functioning by supporting safe activity and targeted rehab after treatment.
Toronto, OntarioAges 18 years+ - NCT05900206RecruitingPhase 2
Trastuzumab deruxtecan vs standard chemotherapy before breast surgery
This Phase 2 study compares trastuzumab deruxtecan to standard chemotherapy given before surgery for HER2-positive breast cancer. It aims to see which treatment works better to shrink the tumor and spread before the operation.
MalmöAges 18 years+ - NCT05919108RecruitingPhase 2
Neratinib before surgery for HER2-mutated invasive lobular breast cancer
This Phase 2 trial tests neratinib given before surgery to treat stage I–III invasive lobular breast cancer that has a specific HER2 mutation and is hormone-receptor positive. It may help shrink the tumor and improve control of cancer before and after surgery.
Atlanta, GeorgiaAges 18 years+ - NCT05921279Recruiting
Study heart events in people with breast cancer
This study looks at what heart-related side effects happen in women with breast cancer who are planned to receive chemotherapy. It may help doctors better understand and monitor these risks during treatment.
GalwayAges 18–90 - NCT05961124RecruitingPhase 2
Lower-dose niraparib to reduce interruptions in ovarian maintenance
This trial tests whether a different starting dose (and adjustments) of niraparib can help people with advanced ovarian (or related) cancer stay on treatment without as many dose interruptions. It’s designed for people who have already finished first-line chemotherapy and whose cancer responded.
Toronto, OntarioAges 18 years+ - NCT05964504Recruiting
Registry study for metastatic lobular breast cancer
This study collects health information from adults with invasive lobular breast cancer that has spread (metastatic) to help researchers understand factors linked to survival. Joining may help build better knowledge for future treatments and care planning.
San Diego, CaliforniaAges 18 years+ - NCT05982093RecruitingPhase 2
Elacestrant with or without triptorelin for premenopausal breast cancer
This trial tests a new hormone-blocking pill (elacestrant) with or without a shot that temporarily stops ovaries (triptorelin) for premenopausal women with early-stage, hormone-sensitive breast cancer. It aims to find a gentler treatment option before surgery.
Badalona, BarcelonaAges 35 years+ - NCT06006390RecruitingPhase 1/Phase 2
CAR-T therapy for CEA-positive advanced solid tumors
This trial tests a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried other treatments.
Taiyuan, ShanxiAges 18 years+ - NCT06006806Recruiting
Proton therapy skin effects study for breast cancer
This study looks at how proton therapy affects the skin in people being treated for early-stage breast cancer. It aims to understand skin reactions better so doctors can reduce side effects.
Knoxville, TennesseeAges 18 years+ - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+ - NCT06039644Recruiting
Probiotics for breast cancer patients on chemotherapy
This trial tests whether taking a probiotic supplement can help breast cancer patients going through chemotherapy. If you are between 20 and 80 years old, have stage I-III breast cancer, and are receiving certain chemo drugs, this study may be for you.
TaipeiAges 20–80 - NCT06052488Recruiting
Strength After Breast Cancer
This study tests a strength training program for women who have finished primary treatment for early-stage breast cancer. The goal is to see if it helps improve muscle strength and overall recovery.
Boston, MassachusettsAges 18 years+ - NCT06087120Recruiting
Can a blood test predict breast cancer treatment response?
This study looks at whether a blood test (ctDNA) can help predict how well breast cancer responds to chemotherapy before surgery. It focuses on people with HER2-positive or triple-negative breast cancer that has not spread far.
JakartaAges 18 years+ - NCT06104618RecruitingPhase 2
Enfortumab vedotin for advanced penile cancer
This trial tests a drug called enfortumab vedotin for people with advanced penile cancer (squamous cell carcinoma) that has spread or cannot be surgically removed. The goal is to see if the drug can shrink tumors or slow the cancer's growth.
Phoenix, ArizonaAges 18 years+ - NCT06126406RecruitingPhase 1
CEA-targeting CAR-T cell therapy for advanced solid tumors
This trial tests a new immune cell therapy (CAR-T) designed to attack cancer cells that make a protein called CEA. It may be an option for people with advanced colorectal, esophageal, gastric, or pancreatic cancer who have already tried at least two standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT06150898RecruitingPhase 2
Ketorolac and pregabalin for estrogen receptor positive breast cancer before surgery
This trial tests whether two medications, ketorolac (a pain reliever) and pregabalin (a nerve pain drug), can help treat estrogen receptor (ER) positive breast cancer when taken before surgery. It may offer better pain control and possibly improve cancer outcomes.
Brussels, Brussels CapitalAges 18–70
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Common questions
- Are there clinical trials for breast cancer stage iii?
- Yes. Clin2 currently lists 523 recruiting breast cancer stage iii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast cancer stage iii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast cancer stage iii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Breast Cancer Early Stage Breast Cancer (Stage 1-3)
- Anatomic Stage III Breast Cancer AJCC v8
- Prognostic Stage III Breast Cancer AJCC v8
- Breast Cancer (Triple Negative Breast Cancer (TNBC))
- Anatomic Stage IV Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Non-small Cell Lung Cancer Stage III
- Anatomic Stage I Breast Cancer AJCC v8
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.