Clinical trials
Breast clinical trials
Below are recruiting breast clinical trials, each written for real people, not researchers. We’re tracking 2,691 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05590949Recruiting
Study of bone problems after stopping breast cancer medicines
This observational study looks at bone complications in post-menopausal women with breast cancer after stopping denosumab and an aromatase inhibitor. It may help doctors better understand who is at risk for bone weakening and fractures after these medicines are stopped.
Basking Ridge, New JerseyAges 18 years+ - NCT05601440RecruitingPhase 2
Trial for metastatic breast cancer that resisted CDK4/6 treatment
This Phase 2 study tests treatments guided by blood testing (“liquid biopsy”) in people with hormone receptor–positive, HER2-negative metastatic breast cancer that has progressed after standard CDK4/6 medicine plus hormone therapy. It aims to find a better way to control cancer after the first treatment stops working.
Calgary, AlbertaAges Any age - NCT05601037Recruiting
Surgery to reduce lymphedema risk after breast lymph node removal
This trial looks at a preventive surgical technique done during breast lymph node removal to lower the chance of developing lymphedema (swelling from blocked fluid) after treatment. If you are at risk, it may help reduce long-term swelling and discomfort.
Ghent, Oost-VlaanderenAges 18–99 - NCT05621564Recruiting
Pre-surgery treatment for women with breast cancer
This trial studies a treatment given before surgery for people with breast cancer. It may help shrink or control the cancer before an operation, depending on what the study drug or approach is.
ShanghaiAges 18 years+ - NCT05627960RecruitingPhase 1
Testing an antibody drug for advanced solid cancers
This Phase 1 study tests AG01, an antibody that targets a cancer protein called GP88, in people with advanced solid tumors. The goal is to find safe doses and learn whether it can help certain cancers.
Baltimore, MarylandAges 18 years+ - NCT05628870RecruitingPhase 1
Testing HRS-1358 for breast cancer that has spread
This early-phase study tests HRS-1358 tablets in people with breast cancer that is locally advanced or has spread. It may help learn whether the drug can control cancer, while also checking safety and how the body handles it.
Beijing, Beijing MunicipalityAges 18–75 - NCT05634889Recruiting
Personalized breast radiation for limited lymph-node spread
This trial studies a tailored form of radiation treatment for some people with early breast cancer whose sentinel lymph-node biopsy shows cancer in 1–2 nodes. It may help improve local control while guiding the best radiation approach for your specific situation.
HelsinkiAges 18 years+ - NCT05638594RecruitingPhase 2
Neoadjuvant drug study for hormone- and HER2-positive breast cancer
This trial compares two combination treatment plans given before breast surgery (neoadjuvant therapy) for ER-positive and HER2-positive stage II–III breast cancer. It aims to see which plan works better to shrink the tumor and improve outcomes.
Shenyang, LiaoningAges 18–75 - NCT05652569Recruiting
Genomics-guided treatment plan for metastatic breast cancer
This trial tests a personalized treatment approach for people with metastatic (advanced spread) breast cancer using tumor testing. It may help guide doctors toward better-matched therapies based on genomic (DNA) information from your tumor.
AugsburgAges 14–100 - NCT05654246Recruiting
ShareForCures breast cancer support and research program
This trial is for adults with breast cancer (or suspected breast cancer) who can take part in an English-language program in the United States. It aims to understand and improve outcomes for people affected by breast cancer.
Dallas, TexasAges 18 years+ - NCT05658172Recruiting
Less vs more frequent follow-up after early breast cancer
This trial compares standard follow-up visits versus more intensive follow-up for people with early breast cancer after their main treatment. The goal is to see whether closer monitoring finds problems earlier or improves outcomes.
UlmAges 18–75 - NCT05658341Recruiting
Program of exercise, nutrition, and support for breast cancer survivors
This study tests a combined program of physical activity, nutrition guidance, and supportive resources to improve quality of life for breast cancer survivors. It may help you feel better physically and emotionally after completing (or nearly completing) treatment.
La Rochelle, Charentes-maritimesAges 18–72 - NCT05659797RecruitingEarly Phase 1
PET scan test for new ER-positive breast cancer
This early study tests a special PET scan (a type of imaging) to look at newly diagnosed ER-positive breast cancer. The goal is to see how well the scan can detect and measure cancer, which may help guide care.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05673304Recruiting
Boost treatment before surgery for luminal B breast cancer
This trial tests a “boost” treatment given before surgery along with standard chemotherapy for luminal B–type breast cancer. It may help improve outcomes by strengthening treatment before the tumor is removed.
BolognaAges 18 years+ - NCT05677022Recruiting
Posture and movement check during adapted exercise after breast cancer
This study looks at how a posture and movement assessment can help guide a tailored exercise program for people treated for non-metastatic breast cancer. It may help ensure the exercise is safer and more suited to your recovery needs.
MarseilleAges 18 years+ - NCT05683418RecruitingPhase 1
Study of a new drug for PIK3CA-mutated HR+ HER2- breast cancer
This early-stage study tests the safety and tolerability of TOS-358 in women with HR-positive, HER2-negative breast cancer that has a specific gene change (PIK3CA). It may help learn whether this targeted treatment is safe enough to move forward.
Chicago, IllinoisAges 18 years+ - NCT05692674RecruitingPhase 2
Proton radiation after breast surgery with implant reconstruction
This trial studies a type of radiation made with proton beams given after mastectomy and implant reconstruction to lower breast cancer coming back. It’s for people who need additional (adjuvant) radiation and have not had prior radiation to the chest or breast.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05696626RecruitingPhase 3
Test a new pill plus abemaciclib versus standard therapy
This Phase 3 study compares lasofoxifene plus abemaciclib versus fulvestrant plus abemaciclib for ER-positive, HER2-negative breast cancer that has an ESR1 mutation. It looks for better tumor control in people whose cancer has progressed on hormone therapy (an aromatase inhibitor) and who meet specific safety and testing requirements.
Scottsdale, ArizonaAges 18 years+ - NCT05704062Recruiting
Breast MRI during chemotherapy to measure treatment response
This study uses breast MRI scans to see whether neoadjuvant (before-surgery) chemotherapy is working. If you qualify, you’ll have MRI scans to help doctors understand how your breast cancer responds to standard treatment.
Iowa City, IowaAges 18 years+ - NCT05704283RecruitingEarly Phase 1
3D ultrasound to check lymph nodes in breast cancer
This early-phase study tests a 3D ultrasound scan to see lymph nodes in people being evaluated for breast cancer. It may help doctors better image lymph nodes during routine care.
Rochester, MinnesotaAges 18 years+ - NCT05710705Recruiting
Bioimpedance monitoring in belly-flap breast reconstruction
This study tests a method called bioimpedance to monitor blood flow in the transplanted belly tissue during breast reconstruction surgery. It may help doctors know when the blood supply is stable, which could lead to safer recovery.
AmiensAges 18 years+ - NCT05716516RecruitingPhase 2
Estradiol pill for ER-positive advanced breast cancer
This trial studies whether an estradiol (a form of estrogen) treatment can help people with ER-positive advanced breast cancer. It is mainly for post-menopausal women whose cancer is not curable and has already been treated with endocrine (hormone) therapies.
Lebanon, New HampshireAges 18 years+ - NCT05728268RecruitingPhase 2
Test dose-dense chemo before surgery for high-growth hormone-positive breast cancer
This Phase 2 study tests a faster, more frequent chemotherapy schedule given before surgery (neoadjuvant therapy) for certain breast cancers that grow quickly. It may help shrink the tumor before the operation and improve treatment response in people who fit the tumor and health criteria.
Shantou, GuangdongAges 18–70 - NCT05731258Recruiting
Watch how liposomal doxorubicin is used after breast cancer
This is an observational study that follows people receiving add-on (adjuvant) chemotherapy after primary breast cancer. It aims to understand treatment patterns and outcomes for patients healthy enough to receive liposomal doxorubicin and who have no major complications.
Hangzhou, ZhejiangAges 18–75
Hear when a new Breast trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for breast?
- Yes. Clin2 currently lists 2,691 recruiting breast studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.