Clinical trials
Breast clinical trials
Below are recruiting breast clinical trials, each written for real people, not researchers. We’re tracking 2,627 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05949983Recruiting
Exercise program for women with breast cancer
This study looks at how a tailored (adapted) physical activity program affects health outcomes and costs for women with breast cancer. It may help you stay active and feel better during or after treatment, while researchers track the program’s overall value.
ToulouseAges 18 years+ - NCT05969860RecruitingPhase 2
Home cancer treatment vs clinic treatment for advanced cancer
This Phase 2 trial compares giving certain standard cancer infusions at home versus in a clinic. It may help people avoid clinic visits while still receiving the same cancer treatment safely.
Jacksonville, FloridaAges 18 years+ - NCT05950945RecruitingPhase 3
Trastuzumab deruxtecan for HER2-low metastatic breast cancer
This trial tests a targeted antibody-drug medicine (trastuzumab deruxtecan, T-DXd) in people with metastatic breast cancer that is HER2-low or HER2 IHC 0. It may help by treating tumors that haven’t previously received anti-HER2 treatment in the metastatic setting.
Miami Beach, FloridaAges 18 years+ - NCT05945329Recruiting
New scar-wrap to treat painful tightness after breast implants
This trial tests a medical mesh/scaffold (GalaFLEX LITE™) used during revision surgery to help treat capsular contracture, where scar tissue tightens around a breast implant. It may improve comfort and the appearance of the breast after implant augmentation problems.
Scottsdale, ArizonaAges 22–70 - NCT05933395RecruitingPhase 2
Targeted treatment for ER+ breast cancer after CDK4/6 therapy
This Phase 2 study tests a genetically guided treatment plan for ER-positive breast cancer that has progressed after CDK4/6 therapy. It may help by matching treatment to tumor genetic changes.
Lebanon, New HampshireAges 18 years+ - NCT05914961Recruiting
Tracking inflammation response in triple-negative breast cancer
This trial studies how a blood inflammation marker (CRP) changes after starting immunotherapy plus chemotherapy in people with triple-negative breast cancer. Results may help doctors predict who benefits from treatment and when.
TübingenAges 18 years+ - NCT05906407Recruiting
Genetic-guided treatment planning for high-risk early breast cancer
This study uses tumor genetic testing to help plan more precise treatment for people with early high-risk breast cancer. You may be asked to give a recent tumor sample so researchers can match your cancer features with the best available options.
AugsburgAges 18–80 - NCT05890677Recruiting
Surgery versus conservative care for chronic breast-related arm swelling
This trial compares microsurgery to standard conservative therapy for long-lasting arm swelling caused by prior breast cancer. It may help people who still have swelling despite months of decongestive treatment by improving quality of life.
New Haven, ConnecticutAges 18 years+ - NCT05878314Recruiting
Testing how hormones and tumor markers guide breast cancer treatment
This study looks at how planned hormone (endocrine) treatment, the menstrual cycle, and lab markers from the tumor may help doctors choose the best treatment for early-stage, hormone-receptor–positive, HER2-negative breast cancer. It may help personalize decisions, including what to do before surgery.
TübingenAges 18 years+ - NCT05879926RecruitingPhase 3
Testing chemo after hormone therapy in premenopausal early breast cancer
This Phase 3 trial checks whether adding chemotherapy after standard hormone-blocking treatment works better for some premenopausal women with early-stage, ER-positive, HER2-negative breast cancer. It targets patients with limited lymph node spread and a lower-to-intermediate tumor “recurrence” risk score.
Birmingham, AlabamaAges 18–60 - NCT05901428RecruitingPhase 3
Check if two breast cancer treatments work better after surgery
This trial compares two treatment approaches in people with high-risk hormone-positive, HER2-negative breast cancer that has spread to certain lymph nodes. It looks at which option works best to lower cancer returning and to control the disease after surgery and initial chemotherapy.
Shanghai, Shanghai MunicipalityAges 18–70 - NCT05902507Recruiting
MRI guidance during breast cancer radiation treatment
This trial studies using MRI images to help plan and guide radiation therapy after breast-conserving surgery. It may help doctors target the right area more accurately while keeping treatment standard and safe.
San Francisco, CaliforniaAges 18 years+ - NCT05909332RecruitingPhase 3
Tested antivascular drug plus chemo versus chemo alone for TNBC
This Phase 3 trial compares an “anti-blood-vessel” drug added to chemotherapy versus chemotherapy alone for people with stage II–IIIC triple-negative breast cancer that has been completely removed with surgery. The goal is to see if adding the study drug improves outcomes after surgery (adjuvant treatment).
Beijing, Beijing MunicipalityAges 18–70 - NCT05894239RecruitingPhase 3
Tested targeted drug for HER2-positive breast cancer with PIK3CA changes
This Phase 3 study tests inavolisib plus Phesgo versus placebo plus Phesgo in people whose breast cancer has both HER2-positive and PIK3CA-mutated tumor markers. The goal is to see if adding inavolisib improves how well the treatment controls the cancer and how safe it is.
Gilbert, ArizonaAges 18 years+ - NCT05860465RecruitingPhase 2/Phase 3
Tested blood cancer medicine with hormone therapy for breast cancer
This trial studies SPH4336 given together with standard hormone (endocrine) therapy for breast cancer that has spread or cannot be treated with surgery. It aims to see whether the combination is safer and more effective than hormone therapy alone.
Guangzhou, GuangdongAges 18–75 - NCT05872347RecruitingPhase 2
Brain metastasis breast cancer trial with hormone therapy plus SPH4336
This trial tests whether SPH4336, added to standard hormone (endocrine) therapy, can improve outcomes for people with breast cancer that has spread to the brain. It also looks closely at safety and side effects.
Hefei, AnhuiAges 18–75 - NCT05856773RecruitingPhase 3
Comparing two proton therapy schedules for breast cancer
This trial compares two ways of giving proton therapy to the breast or chest wall and nearby lymph nodes after surgery. The goal is to see if a shorter course of treatment works just as well as the standard longer course, while possibly reducing side effects.
Scottsdale, ArizonaAges 19 years+ - NCT05876065Recruiting
Maintenance chemotherapy to help control advanced breast cancer
This trial studies whether taking a combination of capecitabine and cyclophosphamide after your best prior treatment can help keep advanced breast cancer from growing. It may help people whose disease has already responded or is stable after “salvage” treatment.
ShanghaiAges 18 years+ - NCT05858398Recruiting
How body composition affects chemotherapy results in breast cancer
This study looks at whether body fat and muscle (body composition) change how well certain chemotherapy works after surgery for early breast cancer. You may be considered if you are planned to receive docetaxel as adjuvant (after-surgery) chemotherapy and have recent CT scan images.
RouenAges 18 years+ - NCT05874492Recruiting
Spa therapy for radiation-related skin fibrosis after cancer
This trial tests whether a spa therapy program can improve “fibrosis,” or stiffened/scarred tissue and related skin problems, after radiotherapy for breast cancer or upper head/neck cancers. It aims to see if treatment can improve quality of life for people who still have moderate-to-worse symptoms months after radiation.
BordeauxAges 18 years+ - NCT05876390Enrolling by invitation
Regional anesthesia to reduce long-term breast surgery pain
This trial studies whether a pain-control technique called regional anesthesia during certain breast surgeries can lower chronic (long-lasting) pain after surgery. It may help improve comfort and quality of life for people at risk of ongoing pain after their breast operation.
Milan, LombardyAges 18 years+ - NCT05866458Recruiting
Radiation after lumpectomy for node-negative breast cancer
This trial studies whether a specific radiation approach after lumpectomy can be helpful for certain people with early breast cancer that did not spread to lymph nodes at diagnosis. It focuses on people who finish neoadjuvant (before-surgery) treatment and reach a full response on final pathology.
Cudgen, CudgenAges 50 years+ - NCT05848141Recruiting
Rowing program after breast cancer treatment
This study looks at whether supervised rowing exercise after breast cancer treatment is safe and helpful for recovery and health. You may be able to join if you finished treatment within the last 6–24 months and have no major exercise-limiting heart or health problems.
Gainesville, FloridaAges 40–80 - NCT05827081RecruitingPhase 3
Ribociclib plus endocrine therapy for early breast cancer
This trial studies whether adding ribociclib to standard hormone (endocrine) therapy lowers the risk of breast cancer coming back in early-stage, hormone-receptor–positive cancer. It mainly looks at safety and how well the treatment controls cancer after surgery and (sometimes) prior hormone treatment.
Birmingham, AlabamaAges 18–100
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Common questions
- Are there clinical trials for breast?
- Yes. Clin2 currently lists 2,627 recruiting breast studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a breast trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a breast trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.