Clinical trials
Cholangiocarcinoma clinical trials
Below are recruiting cholangiocarcinoma clinical trials, each written for real people, not researchers. We’re tracking 185 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06860477RecruitingPhase 2
Freezing therapy plus targeted drugs vs. chemotherapy for advanced bile duct cancer
This trial tests whether a combination of cryoablation (freezing tumors) and two drugs (lenvatinib and tislelizumab) works better than a standard chemotherapy regimen (FOLFOX) for people with advanced intrahepatic cholangiocarcinoma (a type of bile duct cancer in the liver) that has not responded to or has stopped responding to one prior therapy.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07595237RecruitingEarly Phase 1
Radioactive treatment for advanced solid tumors with Claudin18.2
This early-stage trial tests a new radioactive drug (177Lu-DOTA-SNA040) designed to target a protein called Claudin18.2 found on certain cancer cells. The drug delivers radiation directly to tumors in patients with advanced gastric, pancreatic, or bile duct cancers that have stopped responding to standard treatments.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT07744087Recruiting
Comparing two surgical methods for removing tumors near the pancreas
This trial compares two types of surgery to remove tumors that start near the pancreas but not in it. The goal is to see if a newer, less invasive method works as well as the standard approach, which may mean fewer cuts and a faster recovery.
Chongqing, Chongqing MunicipalityAges 18–75 - NCT06910670Recruiting
Web tool for cancer treatment decisions
This trial tests a web-based tool to help people with certain cancers make treatment decisions. It is for patients already enrolled in a related study at Washington University.
St Louis, MissouriAges 18 years+ - NCT05422690RecruitingPhase 2
Treating bile duct cancer with chemo plus Y-90 radiation
This Phase 2 study tests whether combining chemotherapy (gemcitabine and cisplatin) and an immunotherapy drug (durvalumab) with targeted Y-90 radiation can shrink inoperable intrahepatic cholangiocarcinoma tumors. It’s looking for better tumor shrinking and improved cancer control.
Fairfax, VirginiaAges 18 years+ - NCT03445585Recruiting
Biobank study for primary sclerosing and primary biliary cholangitis
This study collects and stores samples from people with PSC (primary sclerosing cholangitis), PBC (primary biliary cholangitis), and some related liver conditions. Researchers use these samples to better understand these diseases and support future research.
Rochester, MinnesotaAges 18–85 - NCT03452774Recruiting
AI matches your cancer tests to possible treatment trials
This trial uses an AI system to help match people with certain cancer types and specific tumor test results (like gene or protein markers) to relevant clinical trials. It may help you and your doctor find studies that fit your cancer biology faster.
Birmingham, AlabamaAges Any age - NCT03637569Recruiting
Skinfold fat measurement and survival in certain digestive cancers
This study looks at whether a simple measurement of fat under the skin (taken at the back of the upper arm) relates to how long people live. It includes adults newly diagnosed with pancreatic, bile duct, or gallbladder cancer who are starting treatment.
SeoulAges 18 years+ - NCT04037007Recruiting
Fistulotomy during ERCP to open the bile duct entrance
This trial looks at whether a specific small procedure during ERCP helps doctors reach and drain the bile duct when gallstones or bile duct narrowing are suspected. It may help people avoid getting stuck during the procedure and improve how successfully the bile duct can be reached.
Mexico City, Mexico CityAges 18–90 - NCT04421820RecruitingPhase 1/Phase 2
BOLD-100 with chemo for advanced gut cancer
This Phase 1/2 study tests whether BOLD-100, given with the standard chemo combination FOLFOX, can help people with advanced gastrointestinal cancers. It’s especially focused on specific tumor features (including BRAF status) and checks safety, dosing, and early signs of effectiveness.
Santa Monica, CaliforniaAges 18 years+ - NCT04504604Recruiting
Study matching rare cancer care with tumor DNA testing
This study looks at people with rare solid tumors or lymphoma to understand their cancer’s genetic changes. It collects blood and existing tissue samples (from standard care) for DNA testing and gathers health information to help improve knowledge about rare cancers.
Cambridge, MassachusettsAges 18 years+ - NCT04510740Recruiting
Liver cancer registry study to improve future care
This study records information about people with liver cancer (hepatocellular or bile duct cancer) to help improve how care is planned and delivered. You may join a patient-experience part before or soon after starting your first main treatment.
Multiple SitesAges 18 years+ - NCT04645160RecruitingPhase 1/Phase 2
Tivozanib for bile duct and gallbladder cancers after chemotherapy
This Phase 1/2 trial tests tivozanib (a targeted anti-cancer drug) in people with bile duct or gallbladder cancer that cannot be removed by surgery and has already been treated with first-line chemotherapy. The study looks at how well the drug works and how safe it is in this setting.
Bethesda, MarylandAges 18 years+ - NCT04753996Recruiting
Testing bile-based “mini-liver” samples in PSC and non-PSC groups
This study collects bile and uses it to grow small lab models (organoids) from people with primary sclerosing cholangitis (PSC) and from people without PSC. Researchers want to better understand how PSC changes bile cells, which could improve future diagnosis or treatments.
Rochester, MinnesotaAges 18–85 - NCT04792463Recruiting
BAP1 gene cancer-risk study and family cancer patterns
This study looks at how the BAP1 gene affects cancer risk and what cancers people develop, including within families. You may be able to join if you have a known BAP1-related mutation, a strong family cancer history, or a concerning cancer pattern linked to BAP1.
Columbus, OhioAges Any age - NCT04946773Recruiting
Deep liver testing study for cancer and non-cancer liver disease
This study looks closely at how the liver’s immune system and disease processes work in people with liver problems, including some with suspected or confirmed liver/bile duct cancer. You may also be offered a liver needle sample (FNA) if it’s safe for you.
Oxford, OxfordshireAges 18–75 - NCT05010681RecruitingPhase 2
Lenvatinib plus immunotherapy after prior liver cancer treatment
This Phase 2 trial tests lenvatinib combined with the immunotherapy drug sintilimab in people with advanced liver cancer who got worse after prior PD-1/PD-L1 treatment. It aims to slow cancer growth and improve outcomes after immune therapy hasn’t worked.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05053555Recruiting
High-dose radiation treatment for hard-to-remove liver tumors
This study uses a form of targeted radiation placed inside/near the liver to treat liver tumors that can’t be surgically removed. It’s meant to shrink or control tumors, especially when they sit near blood vessels or other sensitive organs.
Houston, TexasAges 19 years+ - NCT05179486Recruiting
Study genes and blood markers in bile duct and gallbladder cancers
This study looks at genetic and molecular patterns in people with bile duct or gallbladder cancers, and compares them with people without cancer (or with chronic liver disease). It may help researchers understand why these cancers happen and how to spot risk earlier.
Houston, TexasAges Any age - NCT05187312Recruiting
Registry for advanced endoscopy procedures
This study is a registry that collects information about people who need an endoscopy procedure. It may help doctors learn which approaches work best and improve care over time.
StockholmAges 18 years+ - NCT05342194RecruitingPhase 3
Testing an immunotherapy plus chemo for advanced bile duct cancer
This Phase 3 study tests whether toripalimab (an immunotherapy) combined with lenvatinib and chemotherapy works better than standard treatment for advanced intrahepatic cholangiocarcinoma. It aims to help people live longer and/or control the cancer more effectively.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05451043RecruitingPhase 2
Durvalumab and tremelimumab plus chemotherapy with propranolol
This Phase 2 study tests whether adding propranolol to durvalumab and tremelimumab along with chemotherapy can help control advanced pancreatic cancer, liver cancer, or bile duct cancer. It aims to shrink tumors and help people live longer or feel better when the cancer can’t be cured with surgery or local treatment.
Edmonton, AlbertaAges 18 years+ - NCT05497531Recruiting
Test blood DNA to help guide liver and pancreas biopsies
This pilot study checks whether a special blood test (ctDNA) can detect cancer signals and work as well as another sample method during biopsies for liver, bile duct, or pancreatic cancers. It may help doctors choose the best way to confirm the diagnosis from biopsy samples.
Orange, CaliforniaAges 18 years+ - NCT05551299RecruitingPhase 4
Non-surgical treatment for bile duct cancer using heat or light
This trial tests whether treating hilar bile duct cancer with either radiofrequency ablation (heat) or photodynamic therapy (light-activated medicine) can help patients when surgery isn’t an option. It aims to treat the tumor directly without planned surgery soon.
AachenAges 18 years+
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Common questions
- Are there clinical trials for cholangiocarcinoma?
- Yes. Clin2 currently lists 185 recruiting cholangiocarcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cholangiocarcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cholangiocarcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.