Clinical trials
Cholangiocarcinoma clinical trials
Below are recruiting cholangiocarcinoma clinical trials, each written for real people, not researchers. We’re tracking 189 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07780838RecruitingPhase 2
Combination therapy for advanced bile duct cancer with an FGFR2 change
This study tests a combination of two chemotherapy drugs (gemcitabine and cisplatin) with an immunotherapy drug (durvalumab), alternating with a targeted therapy (pemigatinib) for people with advanced biliary tract cancer that has an FGFR2 gene change. The goal is to see if this treatment sequence helps control the cancer.
Columbus, OhioAges 18 years+ - NCT06058663RecruitingPhase 1
Radiation and immunotherapy for advanced bile duct cancer
This trial tests combining a targeted radiation treatment (radioembolization) with two immunotherapy drugs (tremelimumab and durvalumab) for people with advanced intrahepatic cholangiocarcinoma that cannot be removed by surgery. It aims to shrink tumors and control cancer spread to lymph nodes or one other organ.
Jacksonville, FloridaAges 18 years+ - NCT07161869Recruiting
Lymph node check before surgery for bile duct cancer
This study looks at how well a special ultrasound-guided biopsy checks lymph nodes before surgery or liver transplant for bile duct cancer. The goal is to see if this method accurately shows whether the cancer has spread to nearby lymph nodes.
Rotterdam, South HollandAges 18 years+ - NCT06849180Recruiting
Personalized Treatment for Advanced Combined Liver Cancer
This study is for people with a rare and advanced liver cancer called combined hepatocellular cholangiocarcinoma (CHC). Doctors will use information from your tumor and health history to find the best treatment approach for your specific cancer type.
Nanjing, JiangsuAges 18 years+ - NCT06964425Recruiting
Raman light test for bile duct cancer diagnosis
This study tests a special light technique (Raman spectroscopy) to see if it can help diagnose cancer in the bile ducts outside the liver. It could be an option for people already needing an ERCP procedure.
Olomouc, Olomouc RegionAges 18 years+ - NCT06923475RecruitingPhase 2/Phase 3
Chemo plus immunotherapy before surgery for bile duct cancer
This trial tests whether giving chemotherapy (gemcitabine and cisplatin) combined with immunotherapy (pembrolizumab) before and after surgery can improve outcomes compared to having surgery right away. It is for people with bile duct cancer that can be removed or is borderline removable.
AmsterdamAges 18 years+ - NCT05655949RecruitingPhase 2
Y-90 radiation plus immunotherapy and chemo for bile duct cancer
This trial studies whether combining Y-90 liver radiation with an immunotherapy drug (durvalumab) and chemo (gemcitabine and cisplatin) can better control locally advanced or metastatic intrahepatic cholangiocarcinoma (bile duct cancer in the liver). It may help shrink tumors and slow disease growth, depending on how well the treatment works for your cancer type and overall health.
Boston, MassachusettsAges 18 years+ - NCT07641036RecruitingPhase 1/Phase 2
CAR-NK Cell Therapy for Advanced Biliary Tract Cancer
This trial tests a new type of immune cell therapy (CAR-NK cells) designed to target cancer cells in advanced biliary tract cancers—including bile duct and gallbladder cancers. The cells are engineered to recognize and attack cancer cells that have specific markers (HER2 and CEA), and this approach may help patients whose cancer has progressed after standard chemotherapy.
Shenzhen, GuangdongAges 18 years+ - NCT05321992Recruiting
Village health program to help prevent bile duct cancer
This trial tests whether a community-based behavior change program can lower the risk of cholangiocarcinoma, a bile duct cancer. If you live in one of the selected villages, you may be invited to participate and learn health-focused behavior changes.
Phu Wiang, Changwat Khon KaenAges 20 years+ - NCT07614061RecruitingPhase 1
Cell therapy for advanced bile duct cancer
This trial tests a new treatment called BTC-Ag-T, which uses your own immune cells enhanced in the lab to fight advanced biliary tract cancer (cancer of the bile ducts or gallbladder). It's designed for patients whose cancer has spread or cannot be surgically removed and who have already received standard chemotherapy plus immunotherapy.
ShanghaiAges 18 years+ - NCT07619313RecruitingPhase 1
AB801 with Chemotherapy and Immunotherapy for Bile Duct or Pancreatic Cancer
This study tests a new drug called AB801 combined with standard chemotherapy and immunotherapy for advanced bile duct cancer (cholangiocarcinoma) or pancreatic cancer. The goal is to see if this combination can shrink tumors and help patients live longer.
Los Angeles, CaliforniaAges 18 years+ - NCT06720883Recruiting
Robot-assisted surgery for bile duct cancer
This study tests whether robot-assisted surgery is safe and effective for people with perihilar cholangiocarcinoma (a type of bile duct cancer). It may be a good fit for patients whose cancer has not spread and who are healthy enough for major surgery.
PadovaAges 18 years+ - NCT07176962Recruiting
Blood test for early detection of bile duct cancer
This study is testing a new blood test that looks for signs of DNA changes linked to biliary tract cancer. It aims to see if the test can find these cancers early. If you have biliary tract cancer or a high suspicion of it, you may be able to help.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07030140RecruitingPhase 2
Immunotherapy, radiation and chemo for bile duct cancer
This trial tests a new combination of immunotherapy (tislelizumab), radiation, and chemotherapy before surgery for people with bile duct cancer that is hard to remove. The goal is to shrink the tumor enough to allow successful surgery.
Jinan, ShandongAges 18–75 - NCT06910722Recruiting
Liver transplant for bile duct cancer after treatment
This trial tests if a liver transplant can help people with a certain type of bile duct cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. Before the transplant, you would receive radiation therapy (SIRT) and chemotherapy to shrink the tumor.
Clichy-sous-BoisAges 18–65 - NCT06850753Recruiting
En bloc removal of liver and pancreas with transplant for bile duct cancer
This trial tests a new surgical approach that removes the liver, pancreas, and bile duct all at once (and then gives a liver transplant) for people with a type of bile duct cancer that cannot be removed with standard surgery. It may help people whose cancer is limited to the liver area and who have not responded to other treatments.
OsloAges 18–70 - NCT06140134Recruiting
Liver transplant for bile duct cancer that hasn't spread
This study tests if a liver transplant can help people with a type of bile duct cancer that can't be removed with surgery. You may join if the cancer has stayed stable or shrunk for at least 6 months with treatment.
Newark, New JerseyAges 18–89 - NCT05286814RecruitingPhase 2
Pump-delivered therapy plus chemo for liver-metastatic cancers
This phase 2 study tests a liver-targeted medicine delivered through a special implanted pump, combined with standard chemo, for cancers that spread mainly to the liver. It may help control tumor growth in the liver and improve outcomes compared with standard treatment alone.
Bethesda, MarylandAges 18–120 - NCT03942328RecruitingPhase 1/Phase 2
Immune cell vaccine plus checkpoint treatment after liver radiation
This trial tests a combination of a personalized immune cell treatment (made from your own cells) and a pneumococcal vaccine along with an “immune checkpoint” drug after high-dose radiation for certain unresectable liver cancers. The goal is to help your immune system better attack the cancer and to see how safe and effective this approach is.
Rochester, MinnesotaAges 18 years+ - NCT05184400Recruiting
Find new blood or tumor markers for bile duct and gallbladder cancer
This study looks for new ways to measure cancer-related “biomarkers” (signals in blood or tumor samples) in people with bile duct cancer or gallbladder cancer. The goal is to improve how these cancers are identified and tracked, which could help doctors make better treatment decisions.
Herlev, CopenhagenAges 18 years+ - NCT04078230Recruiting
Extending lymph node removal during liver tumor surgery
This study looks at whether removing more lymph nodes while surgically removing an intrahepatic cholangiocarcinoma (bile duct cancer in the liver) improves outcomes. It may help by better checking and treating possible microscopic spread to lymph nodes.
Baltimore, MarylandAges 18–80 - NCT04556214Recruiting
Liver transplant test for certain bile duct cancers
This trial studies whether a liver transplant can help people with a non-removable type of bile duct cancer in the liver. To be eligible, the cancer must be in the liver only (no spread), and you typically must already have had at least 6 months of treatment before being listed for transplant.
OsloAges 18 years+ - NCT06098547Recruiting
Liver transplant for bile duct cancer that can't be removed
This trial tests if a liver transplant can help people with a certain type of bile duct cancer (intrahepatic cholangiocarcinoma) that cannot be surgically removed. You must have had at least six months of chemotherapy and your cancer must be stable or smaller before you can be listed for a transplant.
PadovaAges 18–70 - NCT05678270RecruitingPhase 2
ICP-192 for FGFR2 fusion bile duct cancer that spread
This Phase 2 trial tests a medicine called ICP-192 in people with intrahepatic bile duct cancer that cannot be removed with surgery and has spread. It is for tumors that have an FGFR2 fusion/rearrangement, especially after prior chemotherapy stopped working.
Hefei, AnhuiAges 18 years+
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Cholangiocarcinoma trials by city
Studies with a site in or near these metro areas.
Cholangiocarcinoma trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cholangiocarcinoma?
- Yes. Clin2 currently lists 189 recruiting cholangiocarcinoma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cholangiocarcinoma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cholangiocarcinoma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.