Clinical trials
Chronic Disease clinical trials
Below are recruiting chronic disease clinical trials, each written for real people, not researchers. We’re tracking 1,256 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07516379Recruiting
Understanding Lung Rejection After Transplant
This study follows people with serious lung disease before and after lung transplant to understand how rejection happens and what warning signs to watch for. By studying your blood, tissue samples, and imaging, researchers hope to better predict and prevent transplant rejection.
Bethesda, MarylandAges 18–75 - NCT04506593Recruiting
GI Motility diagnosis registry for people with digestion movement problems
This trial is a registry, meaning it collects information about people being evaluated for problems with how the gut moves. It may help doctors better diagnose gastrointestinal motility disorders in the future.
Indianapolis, IndianaAges Any age - NCT07303998Recruiting
Brain stimulation and chair yoga for knee pain in Alzheimer's
This study tests two treatments together for people with Alzheimer's who also have chronic knee pain: a gentle brain stimulation (tDCS) and online chair yoga. The goal is to see if these can reduce knee pain and improve daily life.
Tucson, ArizonaAges 60 years+ - NCT07337785RecruitingEarly Phase 1
CAR-T cell therapy for autoimmune diseases
This trial tests a new kind of cell therapy (UCAR-T) that targets CD19 and BCMA proteins on immune cells. It is for people with certain neurological autoimmune diseases like multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinating polyneuropathy, or autoimmune encephalitis who have not responded well to standard treatments.
Wuhan, HubeiAges 18–70 - NCT07369765Recruiting
Balloon vs stent for blocked arteries
This trial compares two procedures to open completely blocked coronary arteries: a drug-coated balloon or a drug-eluting stent. It may help patients with a single, medium-length blockage in a large enough artery.
IstanbulAges Any age - NCT07607197RecruitingPhase 1/Phase 2
Immune Reset to Help Highly Sensitized Kidney Transplant Patients
This study tests whether a special immune-resetting treatment can help patients who have developed too many antibodies against donor kidneys get access to a compatible kidney transplant. The treatment uses chemotherapy and stem cell transplantation to 'reset' your immune system so it stops rejecting potential donor kidneys.
Barcelona, CataloniaAges 18–60 - NCT06966908Recruiting
Managing hepatitis B in non-specialty hospital settings
This study looks at how patients with chronic hepatitis B are managed when they visit non-liver clinics. It aims to improve care and may also include a survey about quality of life for those starting treatment.
Guangzhou, GuangdongAges Any age - NCT06916520RecruitingPhase 4
Reduced dose prasugrel alone after stent placement
This trial tests if a lower dose of prasugrel, taken alone (without aspirin), is safe and works well for people who have had a stent placed for chest pain or a heart attack. It might be an option for those who need to simplify their medication routine.
AmsterdamAges 18 years+ - NCT06763783Enrolling by invitationPhase 4
Shingles vaccine study for people with rheumatic diseases
This study offers the Shingrix shingles vaccine for free to adults with inflammatory rheumatic diseases. It compares how well the vaccine works in people taking immune-suppressing drugs versus those not taking them.
LundAges 18 years+ - NCT06999954Recruiting
Global survey for Shwachman-Diamond syndrome and related conditions
This trial is a global survey and registry for people with Shwachman-Diamond Syndrome and related inherited blood disorders. It aims to connect patients, families, and researchers to better understand these conditions and improve care.
Woburn, MassachusettsAges Any age - NCT07526493RecruitingPhase 1
QH103 Cell Therapy for Resistant Autoimmune Nerve and Brain Diseases
This Phase 1 trial tests whether QH103 cell injections can help patients with serious autoimmune diseases affecting nerves and the brain (like MS, NMOSD, myasthenia gravis, and others) that haven't responded well to standard treatments. The goal is to evaluate safety and whether the treatment helps reduce symptoms.
Wuhan, HubeiAges 18–75 - NCT03913962Recruiting
Exercise study for children with chronic or autoimmune conditions
This study looks at how physical activity affects muscle, metabolism (how your body uses energy), and body composition in children with certain chronic or autoimmune conditions. It may help doctors understand what types of exercise and monitoring are most beneficial and safe.
Clermont-FerrandAges 6–18 - NCT05800210RecruitingPhase 2
T cell and B cell immune “wipeout” after stem cell transplant
This Phase 2 trial studies whether removing certain immune cells (alpha/beta T cells and CD19+ B cells) around the time of a stem cell transplant can improve outcomes for people with high-risk blood cancers. It may help by reducing the immune responses that can interfere with the transplant working, while keeping the process safe.
Gainesville, FloridaAges 6 months–39 years - NCT06810505RecruitingPhase 3
Oral atogepant for preventing migraines in teens
This trial tests an oral medication called atogepant to see if it can prevent migraines in teens aged 12–17. It aims to reduce how often migraines happen and track any side effects.
Huntsville, AlabamaAges 12–17 - NCT07021495Recruiting
Skin disease study to improve treatment choices
This study looks at different skin diseases to find markers that can help guide treatment. It tests new treatments for several conditions like eczema, psoriasis, and lupus, with the goal of personalizing care.
Nijmegen, GelderlandAges 18 years+ - NCT07461896Recruiting
Nerve function study in Charcot-Marie-Tooth and related neuropathies
This study looks at how nerves work and their structure in people with Charcot-Marie-Tooth disease, CIDP, or anti-MAG neuropathy. It may help doctors better understand these conditions.
MilanAges 18 years+ - NCT06373848Enrolling by invitation
Vitamin E and Coenzyme Q10 for early gum disease
This study tests whether adding vitamin E and coenzyme Q10 to standard gum treatment can help heal early-stage chronic gum disease. It is for otherwise healthy adults aged 28-35 with mild gum pockets on their lower molars.
TehranAges 28–40 - NCT05009758Recruiting
Asthma and nasal polyps study to match immune patterns
This study looks at different “immune inflammation patterns” in people with asthma and/or nasal polyps. It may help researchers better tailor future treatments by figuring out which patterns go with which symptoms.
ViennaAges 18–99 - NCT01386437Recruiting
Study immune problems and fungal infections
This study looks at how immune system problems relate to fungal infections, using medical records and lab tests on blood and tissue. It may help researchers understand the cause of these infections—especially for people with inherited immune conditions—and improve future care.
Bethesda, MarylandAges 1 day–99 years - NCT05642156Recruiting
Ultrafiltration versus usual dialysis in people on hemodialysis
This study compares a specific way of removing fluid during dialysis (isolated ultrafiltration) with conventional hemodialysis. It aims to see how each approach affects blood flow and fluid shifts in people with end-stage kidney disease.
GrazAges 18 years+ - NCT06191640Recruiting
Study of sinus disease in young children with cystic fibrosis
This study looks at sinus problems in young children with cystic fibrosis. One group of children starts a new medicine called a highly effective modulator (like Trikafta), and the other group does not take this medicine. The goal is to see how the medicine affects sinus health over time.
Aurora, ColoradoAges 2–8 - NCT06550115Recruiting
Night shift workers and their blood vessel & sugar health
This trial studies how sleep patterns affect blood vessel health and sugar control in long-term night shift workers. It may help find better ways to prevent heart problems and diabetes.
Fort Collins, ColoradoAges 18–65 - NCT06843018RecruitingPhase 2
Spray vs lozenge for sore throat from infection
This trial tests a new spray with anesthetic for sore throat caused by infections like pharyngitis. It compares the spray to a lozenge (Septolete Total) to see which works better and is safer.
Engel'sAges 18–75 - NCT07249346RecruitingPhase 2
Preventing GVHD after stem cell transplant with three drugs
This trial tests a three-drug combination (cyclophosphamide, tacrolimus, and ruxolitinib) to prevent graft-versus-host disease (GVHD) after a stem cell transplant. It is for people with certain blood cancers who have a matched donor and can tolerate high-dose chemotherapy.
Columbus, OhioAges 18 years+
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Common questions
- Are there clinical trials for chronic disease?
- Yes. Clin2 currently lists 1,256 recruiting chronic disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.