Clinical trials
Chronic Fatigue clinical trials
Below are recruiting chronic fatigue clinical trials, each written for real people, not researchers. We’re tracking 42 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05525598Recruiting
Online therapy for severe body–mind symptom disorders
This trial tests an internet-based treatment program for people with moderate-to-severe functional somatic disorders (long-lasting physical symptoms linked to how the body and brain interact). It may help reduce symptoms and improve day-to-day functioning by offering structured support online.
Aarhus C, DenmarkAges 18–60 - NCT05741112Recruiting
Long COVID wearable study to track symptoms and help daily management
This study uses a wearable device to track symptoms and patterns in people with Long COVID, ME/CFS, and/or POTS. The goal is to see how wearable feedback and tracking tools may help you manage your symptoms.
La Jolla, CaliforniaAges 18 years+ - NCT07009691Recruiting
Hydrogen water for ME/CFS patients
This trial tests whether drinking hydrogen-rich water can improve heart rate variability (a measure of nervous system function) in people with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome). The goal is to see if this simple intervention helps reduce symptoms.
Stony Brook, New YorkAges 18–65 - NCT07551999Recruiting
Voice Analysis Tool for ME/CFS Diagnosis and Monitoring
This study tests a smartphone app that analyzes your voice to help diagnose and track myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—a condition causing extreme tiredness and other symptoms. Researchers want to see if voice patterns can be a simple, at-home way to monitor your condition over time.
Rochester, MinnesotaAges 18 years+ - NCT07320937Enrolling by invitation
Yiqi Fuyuan Paste formula for chronic fatigue syndrome
This trial tests whether a traditional Chinese medicine formula (Yiqi Fuyuan Paste) can help reduce fatigue in people with chronic fatigue syndrome. It is a double-blind, placebo-controlled study, meaning neither you nor the doctor will know which treatment you receive.
Shanghai, Pudong New AreaAges 18–65 - NCT07256795Enrolling by invitation
ME/CFS after COVID-19 vs. before the pandemic
This study looks at how the brain's protective barrier and immune system work in people with ME/CFS, comparing those who got sick before the COVID-19 pandemic to those who developed ME/CFS after a COVID-19 infection. It aims to understand why some people have lasting brain fog, fatigue, and other neuropsychiatric symptoms.
Baltimore, MarylandAges 18–70 - NCT07426991Recruiting
Multiple sclerosis, thinking, sleep, and tiredness study
This study looks at how multiple sclerosis (MS) affects your thinking, sleep, and tiredness. It compares people with MS who have at least mild fatigue to people without MS who also have sleep problems, to understand these issues better.
DüsseldorfAges 18–79 - NCT06472622RecruitingEarly Phase 1
Brain imaging study of pain and effort
This study uses brain scans to understand how people experience pain and effort. It compares healthy volunteers to people with ME/CFS to see if there are differences in brain activity.
Bethesda, MarylandAges 18–50 - NCT06851195Enrolling by invitation
Electrical stimulation for leg strength in COPD
This trial tests whether a gentle electrical stimulation applied to your leg muscles can help you feel less breathless and less tired during daily activities, and improve your confidence in exercising. It is for people with stable COPD who are already in a pulmonary rehab program.
Kaohsiung, TaiwanAges 18 years+ - NCT07525063Enrolling by invitation
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation technique (called TMS) can help reduce pain and improve mood in women with fibromyalgia. Researchers will use MRI scans and brain stimulation to understand how pain and reward circuits in the brain work.
Durham, North CarolinaAges 18 years+ - NCT05094297Recruiting
Study of muscle contraction training for veteran tiredness and pain
This study tests whether a guided exercise approach using focused muscle contractions can improve pain, fatigue, or low energy in U.S. Veterans. If you’re having trouble doing everyday activities, this program may help you feel better and function more easily.
Chicago, IllinoisAges 18 years+ - NCT04984226RecruitingPhase 2
Sodium bicarbonate for kidney disease energy and acidity
This trial studies whether taking sodium bicarbonate changes “energy” in cells and improves metabolic acidosis (an acid build-up) in people with moderate-to-severe chronic kidney disease. You may be able to join if your kidney function and blood bicarbonate levels fit their targets and you meet safety rules.
Sacramento, CaliforniaAges 21–85 - NCT06860880Recruiting
Personalized program to fight cancer-related fatigue
This trial tests a personalized supportive care program that combines exercise, nutrition, and coaching to help reduce fatigue in people with certain slow-growing lymphomas. It aims to improve energy and quality of life.
Chapel Hill, North CarolinaAges 18 years+ - NCT07252219Recruiting
How ankle muscle fatigue affects balance in unstable ankles
This study looks at how getting your ankle muscles tired changes your ability to sense force and control movement. It compares people with chronic ankle instability to healthy volunteers to find better ways to prevent re-injury.
LjubljanaAges 18–45 - NCT05235685Recruiting
Testing muscle fatigue during exercise in COPD and heart failure
This study looks at how tired your muscles get during a controlled cycling exercise test in people who have COPD, and—if applicable—heart failure at the same time. It may help researchers understand exercise limits and how to better support you with these conditions.
Échirolles, Auvergne-Rhône-AlpesAges 18 years+ - NCT07227441Recruiting
Chronic Infections and Inflammation in ME/CFS
This study looks at how chronic infections and inflammation affect people with ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) compared to healthy people. Researchers want to understand what causes symptoms and find better ways to help.
San Francisco, CaliforniaAges 18 years+ - NCT07209527Enrolling by invitationEarly Phase 1
Truway diagnostic tools in primary care
This trial tests new diagnostic tools that doctors can use in primary care. Researchers want to see if these tools help find the right diagnosis faster and more accurately.
New York, New YorkAges Any age - NCT07317271Recruiting
Virtual reality for burn symptoms
This trial tests a virtual reality program to help with symptoms like pain, trouble sleeping, and itching after a burn injury. You can join from home using your own device.
Baltimore, MarylandAges 18 years+
Hear when a new Chronic Fatigue trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic fatigue?
- Yes. Clin2 currently lists 42 recruiting chronic fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.