Clinical trials
Chronic Fatigue clinical trials
Below are recruiting chronic fatigue clinical trials, each written for real people, not researchers. We’re tracking 44 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07523113Recruiting
Brain Fog Treatment for ME/CFS Using Cognitive Training
This study tests whether a computerized cognitive training program combined with a mild electrical nerve stimulation device (worn on the ear) can help improve thinking and memory problems in people with ME/CFS. The goal is to see if this approach helps with brain fog and daily functioning.
Birmingham, AlabamaAges 18 years+ - NCT03773003Recruiting
Study of fatigue caused by cancer or chronic fatigue
This study looks at why fatigue happens in people with cancer and, in some cases, in people with chronic fatigue conditions. It may help researchers better understand the causes of fatigue so future treatments can be improved.
Homburg, SaarlandAges 18–80 - NCT05168124Recruiting
Therapy or short breaks for chronic fatigue syndrome (CFS/ME)
This study tests whether Acceptance and Commitment Therapy (ACT) or doing brief “micro breaks” can improve symptoms in people with CFS/ME. It checks safety and whether you can follow the online program over the study period.
ZurichAges 18–55 - NCT06170645Recruiting
Vagus nerve stimulation for fatigue in fibromyalgia or long COVID
This trial tests whether a gentle electrical stimulation device on the ear (vagus nerve) can help reduce fatigue when combined with exercise. It is for people with fibromyalgia or long COVID who still feel exhausted after a rehab program.
Saint-EtienneAges 18 years+ - NCT07546539Recruiting
Light Therapy for Chronic Fatigue Syndrome
This study tests whether a special type of light therapy (called photobiomodulation) can reduce severe tiredness in people with chronic fatigue syndrome. The light is applied to the skin and may help boost energy levels and improve daily function.
Larkana, SindhAges 18–60 - NCT06775262Recruiting
chronic fatigue in internal medicine patients
This study looks at people with chronic fatigue who saw a doctor but no physical cause was found. It aims to understand their experiences better.
Almere Stad, FlevolandAges 18 years+ - NCT07491315Recruiting
Do ME/CFS patients react differently to exercise?
This study looks at whether people with ME/CFS have a different reaction to exercise compared to people with heart conditions who also feel tired. It involves filling out online questionnaires and may help doctors better understand ME/CFS.
MarseilleAges 18 years+ - NCT03675087Recruiting
Testing how exercise affects symptoms in ME/CFS
This trial studies how people with ME/CFS respond to an exercise test. It may help researchers understand what kind of exercise response is typical and how it relates to symptoms.
MadridAges 18–65 - NCT07637084Recruiting
Light therapy for chronic pain and fatigue in Ehlers-Danlos Syndrome
This trial tests whether a non-invasive light therapy called photobiomodulation can reduce chronic pain and fatigue in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a genetic condition affecting connective tissue. The light is applied to the skin and may help cells produce energy and reduce inflammation.
Boulogne-Billancourt, Île-de-France RegionAges 18 years+ - NCT04151693Recruiting
Group therapy for chronic fatigue syndrome
This trial tests a health-psychology–based rehabilitation program delivered in a group setting for people with chronic fatigue syndrome (ME/CFS). It may help by teaching strategies to cope with symptoms and improving daily functioning through structured group support.
LahtiAges 18–65 - NCT06829940Recruiting
Baduanjin exercise for long COVID fatigue
This trial tests whether Baduanjin, a gentle mind-body exercise, can help people under 50 with long-standing chronic fatigue that's worse after COVID-19. It aims to see if this safe, low-impact practice improves energy and daily life without needing extra treatments.
CairoAges 18–50 - NCT07753122Recruiting
Hydrogen water for chronic fatigue syndrome
This trial tests whether drinking hydrogen water can help with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). If you have ME/CFS, this study might show if hydrogen water is a helpful treatment.
Stony Brook, New YorkAges 18–65 - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT07621068Recruiting
Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome
This study tests whether breathing pure oxygen in a pressurized chamber can reduce fatigue and improve symptoms in people with mild-to-moderate chronic fatigue syndrome (ME/CFS). The therapy may help your body recover better by increasing oxygen supply to affected tissues.
ZrifinAges 18 years+ - NCT05584124RecruitingPhase 2
Brain stimulation treatment for lasting fatigue after stroke
This trial tests a non-painful brain stimulation method (repetitive magnetic pulses) to see if it can reduce fatigue that continues long after a stroke. It may help people whose stroke fatigue has lasted more than six months and who can safely undergo repeated sessions.
Decatur, GeorgiaAges 34–80 - NCT06082518Recruiting
Hyperbaric oxygen for long COVID recovery
This trial tests if hyperbaric oxygen therapy, which involves breathing pure oxygen in a pressurized room, can help people with post-COVID syndrome feel better. It focuses on those dealing with ongoing fatigue and brain fog or anxiety.
Toronto, OntarioAges 18 years+ - NCT07242573Recruiting
Exercise and brain stimulation for fibromyalgia
This study tests if combining physical exercise with a gentle brain stimulation technique can improve pain, sleep, and fatigue in people with fibromyalgia.
Warsaw, Masovian VoivodeshipAges 20–80 - NCT05587777Recruiting
Tracking chronic conditions during standard breast cancer treatment
This study monitors health problems that can happen over time in people with breast cancer while they receive usual treatments like hormone therapy, chemotherapy, and/or radiation. It may help researchers understand which extra symptoms or complications show up and when, to improve care and follow-up.
StavangerAges 19–80 - NCT07273097Recruiting
Ankle muscle fatigue and walking in ankle instability
This trial studies how tired ankle muscles affect walking in people with chronic ankle instability. It compares their walking patterns to healthy people to understand if fatigue makes ankle issues worse.
LjubljanaAges 18–45 - NCT04049331RecruitingPhase 2
Testosterone therapy for cancer survivors with fatigue
This trial tests whether testosterone replacement can help male cancer survivors who have ongoing fatigue and low testosterone levels. It is for men who have completed chemotherapy or radiation and are cancer-free for at least a year.
Boston, MassachusettsAges 18–54 - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT06660888Enrolling by invitation
Study of fatigue, depression, and anxiety in people with low thyroid
This study looks at how common fatigue, depression, and anxiety are in people with hypothyroidism (underactive thyroid). It aims to understand if these symptoms are linked to thyroid hormone levels.
Asyut, AssuitAges 18–60 - NCT07715838Recruiting
PEM as a starting point to study ME/CFS
This study looks at how post-exertional malaise (PEM) affects people with ME/CFS. It aims to understand the condition better and find new ways to help.
GroningenAges 18–65 - NCT03759522RecruitingPhase 1
PET brain scan for inflammation in MS, fibromyalgia, or CFS
This early-stage study tests an imaging medicine ([F-18]DPA-714) that can help researchers see inflammation in the brain and nervous system. It may help doctors better understand how “inflammation signals” differ across conditions like multiple sclerosis, fibromyalgia, and chronic fatigue syndrome.
Birmingham, AlabamaAges 18–65
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Common questions
- Are there clinical trials for chronic fatigue?
- Yes. Clin2 currently lists 44 recruiting chronic fatigue studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic fatigue trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic fatigue trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.