Clinical trials
Chronic Knee Pain clinical trials
Below are recruiting chronic knee pain clinical trials, each written for real people, not researchers. We’re tracking 135 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07178951Recruiting
Ultrasound-guided nerve treatment for knee osteoarthritis pain
This trial tests a non-surgical treatment that uses ultrasound to target nerves causing pain on the inner side of your knee due to osteoarthritis. It may help reduce pain and improve function for people with moderate to severe knee pain.
North York, OntarioAges 18 years+ - NCT07119645Recruiting
Collagen supplement for knee discomfort relief
This trial tests whether a daily collagen supplement (NT-II™) can reduce knee discomfort during activities like walking or climbing stairs. You may qualify if you have mild to moderate knee pain during exercise, no arthritis, and are generally healthy.
San Francisco, CaliforniaAges 20–65 - NCT07057063Recruiting
Light therapy for knee pain and swelling
This study tests if light therapy can reduce knee pain and swelling (synovitis) caused by arthritis. If you have long-lasting knee pain and arthritis, this treatment might offer a non-drug option to help you feel better.
ShenzhenAges 40–80 - NCT06466330Recruiting
Knee embolization for post-replacement pain
This trial tests a non-surgical treatment called microparticle geniculate artery embolization for people with persistent knee pain after a total knee replacement. It aims to reduce pain by blocking tiny blood vessels that may be causing inflammation.
CréteilAges 40–80 - NCT07001449Recruiting
Pain education for chronic muscle or joint pain
This study tests a type of pain education that focuses on communication to help people with long-term muscle or joint pain. It aims to see if learning about pain in a new way can help reduce symptoms and improve quality of life.
Lamia, Central GreeceAges 18–65 - NCT06239649Recruiting
Nerve block before knee replacement for faster recovery
This trial tests whether a numbing injection (nerve block) around the knee before surgery can help you recover faster and feel less pain after a total knee replacement. It is for people with knee osteoarthritis who are ready for their first knee replacement surgery.
Denizli, PamukkaleAges 40–85 - NCT05816798RecruitingPhase 2/Phase 3
Laser treatment to reduce chronic knee pain before weight-surgery
This trial tests whether photobiomodulation (a type of laser/light therapy) can reduce chronic pain in both knees for people preparing for bariatric (weight-loss) surgery. If you have knee pain that limits daily life, the treatment may help you feel better while you’re in the pre-surgery rehabilitation period.
Goiânia, GoiásAges 18–70 - NCT06915363Recruiting
BioPoly implant for knee cartilage repair
This trial tests a BioPoly implant to repair a small damaged cartilage spot in your knee. If you have a specific type of cartilage injury that didn't get better with other treatments, this implant may help relieve pain and improve function.
Fort Wayne, IndianaAges 30–65 - NCT06906211Recruiting
Ultrasound for chronic back pain in veterans
This trial tests if a gentle ultrasound treatment to a specific part of the brain can help veterans with chronic back pain. It aims to see if targeting the insula can reduce pain that spreads to other areas of the body.
Washington D.C., District of ColumbiaAges 21–75 - NCT06837857RecruitingPhase 2
Opioid pain relief study for older adults with chronic pain
This study tests whether a carefully managed prescription opioid can safely help older adults with long-term pain that hasn't been relieved by other pain medicines. The goal is to see if it improves pain without harming memory or brain health.
Rochester, MinnesotaAges 65 years+ - NCT06800209RecruitingPhase 2
Pain Reprocessing Therapy for ongoing knee pain after replacement
This study tests if Pain Reprocessing Therapy can help reduce knee pain that continues 3 months after a knee replacement. It uses a telehealth approach so you can participate from home.
Aurora, ColoradoAges 18 years+ - NCT05700682Recruiting
MRI-guided artery blockage procedure for long-term joint pain
This study tests whether an MRI scan that looks at blood flow can help target a joint embolization procedure to reduce chronic shoulder, hip, or knee pain. It first uses MRI to find signs of increased blood flow, then may use the findings to guide treatment if you qualify.
Palo Alto, CaliforniaAges 25–80 - NCT06512727Recruiting
Pain management study for Black older adults with long-term joint pain
This study tests two different approaches to help Black adults aged 50–92 manage chronic muscle or joint pain in their hips, knees, lower back, or ankles. It aims to find which method works better to reduce pain and improve daily life.
Gainesville, FloridaAges 50–92 - NCT06123715RecruitingPhase 2
Vitamin C to reduce pain after knee replacement
This study tests whether taking vitamin C before and after knee replacement surgery can reduce long-term pain. You may be eligible if you are having knee replacement for osteoarthritis and are generally healthy.
Toronto, OntarioAges 18 years+ - NCT06083480RecruitingPhase 4
Reducing stress to prevent long-term pain after knee replacement
This trial tests if lowering oxidative stress (damage from natural body processes) during knee replacement surgery can prevent chronic pain afterward. It may help people with osteoarthritis who have moderate to severe pain before surgery.
Nashville, TennesseeAges 50 years+ - NCT06038240Recruiting
Pain self-management program for knee replacement
This study is testing a program to help people manage pain on their own before and after total knee replacement surgery. It aims to improve recovery and reduce reliance on pain medications.
Charlottesville, VirginiaAges 18–85 - NCT06004882Recruiting
Nerve stimulation vs. steroid injection for chronic knee pain
This study compares two treatments for long-term knee pain: a nerve stimulation device placed near the knee versus a steroid shot into the joint. The goal is to see which works better for pain relief.
Houston, TexasAges 18 years+ - NCT05986292RecruitingPhase 2
Study of new pain treatments for chronic pain
This study tests new treatments for people with chronic pain that has lasted at least 12 weeks. It aims to find better ways to reduce pain and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT05920382Recruiting
Radiofrequency treatment for long-term knee pain after knee surgery
This trial studies whether a radiofrequency procedure can reduce chronic knee pain after knee replacement surgery. It may help people who still have bothersome pain between 6 months and 5 years after their operation, as long as their pain pattern and medications are stable.
Barcelona, CataloniaAges 18 years+ - NCT05596591Recruiting
Shockwave treatment for knee arthritis pain with MRI-confirmed lesions
This trial tests whether focused shockwave therapy (a non-surgical treatment) can reduce knee arthritis pain. It specifically targets people whose MRI shows a small bone problem in one area of the knee.
Cedar Knolls, New JerseyAges 30–80 - NCT07682519Recruiting
Home vs. in-person rehab for hemophilia pain
This study compares a rehabilitation program you can do at home using video calls (telerehabilitation) with in-person rehabilitation sessions. The goal is to see if the home-based option works as well as office visits for reducing chronic joint pain in adults with hemophilia.
Santiago, Santiago MetropolitanAges 18–60 - NCT07226258RecruitingPhase 3
Testing SL1002 for knee pain caused by osteoarthritis
This trial tests a study drug called SL1002 to see if it reduces knee pain from osteoarthritis. It may be an option for people with chronic knee pain who haven't found enough relief from current treatments.
Roseville, CaliforniaAges 40 years+ - NCT06004804Recruiting
Psychological treatments for chronic pain in veterans
This study compares two group psychological treatments for chronic pain delivered over video conference. It aims to see if these treatments help reduce pain and improve quality of life for veterans.
West Los Angeles, CaliforniaAges 60–95 - NCT06671925Recruiting
Support program for chronic pain and loneliness in older adults
This trial tests a program led by community health workers to help older adults manage chronic pain and reduce loneliness. It aims to improve your well-being through support and guidance.
Ann Arbor, MichiganAges 60 years+
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Common questions
- Are there clinical trials for chronic knee pain?
- Yes. Clin2 currently lists 135 recruiting chronic knee pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic knee pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic knee pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.