Clinical trials
Chronic Lyme Disease clinical trials
Below are recruiting chronic lyme disease clinical trials, each written for real people, not researchers. We’re tracking 15 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT06026969Recruiting
Study on Lyme disease and baby development after pregnancy exposure
This study looks at how Lyme disease during pregnancy might affect a baby's development. It involves questionnaires and possibly an MRI of the baby's brain, done at a visit or remotely.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06397794Recruiting
Pregnancy and parenting with Lyme disease study
This study explores the experiences of people who had Lyme disease during pregnancy or had ongoing Lyme symptoms throughout their pregnancy. By sharing your story in a recorded interview, you can help doctors and researchers better support parents with Lyme disease.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT06655844Recruiting
Sana Device for chronic pain from Lyme disease
This study tests the Sana device—a special light and sound tool—to see if it can help reduce chronic nerve pain in people with Post-Treatment Lyme Disease Syndrome. You may be able to join if you have ongoing nerve pain after Lyme treatment and meet a few basic health and medication rules.
New York, New YorkAges 18 years+ - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT05776251Recruiting
Noninvasive nerve stimulation for ongoing Lyme symptoms
This trial tests whether taVNS (a noninvasive nerve stimulation done through the skin near the ear) can reduce long-lasting symptoms after Lyme disease. It targets people whose symptoms have stayed for months after standard antibiotic treatment.
New York, New YorkAges 18–65 - NCT06611111RecruitingEarly Phase 1
Ceftriaxone for lingering fatigue after Lyme disease
This study tests whether a short course of a strong antibiotic (ceftriaxone) can help people who still have fatigue and other symptoms after being treated for Lyme disease. It aims to see if this treatment can improve your quality of life.
East Syracuse, New YorkAges 18–75 - NCT06915324Recruiting
Electric brain stimulation for Lyme disease cognitive issues
This study tests if a gentle electrical current applied to the scalp can improve thinking problems (like slow processing speed) that continue after Lyme disease treatment. It could help you if you have mental fog or memory trouble that hasn't gone away with antibiotics.
San Francisco, CaliforniaAges 18–70 - NCT00001539Recruiting
Understanding Symptoms After Lyme Disease Treatment
This research study examines why some people continue to have symptoms months after being treated for Lyme disease. Researchers will compare patients with ongoing symptoms to people who recovered well, to better understand what causes lasting problems and how to help.
Bethesda, MarylandAges 13–99 - NCT04402086Recruiting
Rheumatology patient and skin sample registry study at Yale
This study builds a health record and blood/skin sample collection for people with rheumatic autoimmune diseases who are getting care at Yale. It may help researchers understand these conditions and develop better tests or treatments over time.
New Haven, ConnecticutAges 18–99 - NCT05036707RecruitingPhase 1/Phase 2
Study how tick bites change immune responses
This study looks at how a person’s immune system responds after exposure to Ixodes (black-legged) tick bites. It aims to better understand the body’s early immune reaction after tick exposure, using blood tests and small skin samples.
Bethesda, MarylandAges 18–99 - NCT06451913RecruitingPhase 4
Probiotic for gut health during Lyme disease antibiotics
This trial tests if a probiotic (Saccharomyces boulardii) can help maintain healthy gut bacteria while you take antibiotics for the early skin rash of Lyme disease (erythema migrans). You'll take amoxicillin for 14 days, plus either the probiotic or a placebo.
LjubljanaAges 18 years+ - NCT05641116Recruiting
Exercise plus education program for long-lasting Lyme-related symptoms
This trial tests whether a combined program of adapted exercise and therapeutic education can improve long-lasting symptoms that are thought to be related to Lyme disease. It may help people who have symptoms for over 6 months and are not very active currently.
Clermont-FerrandAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age
Hear when a new Chronic Lyme Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for chronic lyme disease?
- Yes. Clin2 currently lists 15 recruiting chronic lyme disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic lyme disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic lyme disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.