Clinical trials
Lyme Disease clinical trials
Below are recruiting lyme disease clinical trials, each written for real people, not researchers. We’re tracking 20 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04806620Recruiting
Online app study for brain inflammation lifestyle data
This study uses a digital platform (app/website) to collect lifestyle and symptom information to better understand brain inflammation. You may qualify if you have certain conditions like Long COVID, migraines, autoimmune disease, inflammatory gut issues, mood disorders, or if you are a healthy comparison person.
Delafield, WisconsinAges 2 years+ - NCT00028080Recruiting
Evaluation and treatment for active Lyme disease
This study evaluates and treats people who currently have active Lyme disease, as defined by CDC criteria. It aims to provide expert care and follow-up while studying the disease.
Bethesda, MarylandAges 2–99 - NCT06026969Recruiting
Study on Lyme disease and baby development after pregnancy exposure
This study looks at how Lyme disease during pregnancy might affect a baby's development. It involves questionnaires and possibly an MRI of the baby's brain, done at a visit or remotely.
Washington D.C., District of ColumbiaAges 18 years+ - NCT06397794Recruiting
Pregnancy and parenting with Lyme disease study
This study explores the experiences of people who had Lyme disease during pregnancy or had ongoing Lyme symptoms throughout their pregnancy. By sharing your story in a recorded interview, you can help doctors and researchers better support parents with Lyme disease.
Washington D.C., District of ColumbiaAges 18 years+ - NCT07500506RecruitingPhase 3
Safety of a fifth dose of the Lyme disease vaccine
This study is for people who have already received four doses of the Lyme vaccine (VLA15) in a previous study. It tests whether a fifth dose is safe and helps the body build more protection against Lyme disease.
Bangor, MaineAges 7 years+ - NCT05776251Recruiting
Noninvasive nerve stimulation for ongoing Lyme symptoms
This trial tests whether taVNS (a noninvasive nerve stimulation done through the skin near the ear) can reduce long-lasting symptoms after Lyme disease. It targets people whose symptoms have stayed for months after standard antibiotic treatment.
New York, New YorkAges 18–65 - NCT06611111RecruitingEarly Phase 1
Ceftriaxone for lingering fatigue after Lyme disease
This study tests whether a short course of a strong antibiotic (ceftriaxone) can help people who still have fatigue and other symptoms after being treated for Lyme disease. It aims to see if this treatment can improve your quality of life.
East Syracuse, New YorkAges 18–75 - NCT06915324Recruiting
Electric brain stimulation for Lyme disease cognitive issues
This study tests if a gentle electrical current applied to the scalp can improve thinking problems (like slow processing speed) that continue after Lyme disease treatment. It could help you if you have mental fog or memory trouble that hasn't gone away with antibiotics.
San Francisco, CaliforniaAges 18–70 - NCT00001539Recruiting
Understanding Symptoms After Lyme Disease Treatment
This research study examines why some people continue to have symptoms months after being treated for Lyme disease. Researchers will compare patients with ongoing symptoms to people who recovered well, to better understand what causes lasting problems and how to help.
Bethesda, MarylandAges 13–99 - NCT06655844Recruiting
Sana Device for chronic pain from Lyme disease
This study tests the Sana device—a special light and sound tool—to see if it can help reduce chronic nerve pain in people with Post-Treatment Lyme Disease Syndrome. You may be able to join if you have ongoing nerve pain after Lyme treatment and meet a few basic health and medication rules.
New York, New YorkAges 18 years+ - NCT06511050RecruitingPhase 1/Phase 2
Testing Lumbrokinase for Long COVID, Lyme, and Chronic Fatigue
This trial tests a supplement called Lumbrokinase (derived from earthworms) to see if it helps reduce symptoms in people with Long COVID, post-treatment Lyme disease syndrome, or ME/CFS. It may benefit those whose daily life is significantly affected by these conditions.
New York, New YorkAges 18 years+ - NCT04402086Recruiting
Rheumatology patient and skin sample registry study at Yale
This study builds a health record and blood/skin sample collection for people with rheumatic autoimmune diseases who are getting care at Yale. It may help researchers understand these conditions and develop better tests or treatments over time.
New Haven, ConnecticutAges 18–99 - NCT05036707RecruitingPhase 1/Phase 2
Study how tick bites change immune responses
This study looks at how a person’s immune system responds after exposure to Ixodes (black-legged) tick bites. It aims to better understand the body’s early immune reaction after tick exposure, using blood tests and small skin samples.
Bethesda, MarylandAges 18–99 - NCT06451913RecruitingPhase 4
Probiotic for gut health during Lyme disease antibiotics
This trial tests if a probiotic (Saccharomyces boulardii) can help maintain healthy gut bacteria while you take antibiotics for the early skin rash of Lyme disease (erythema migrans). You'll take amoxicillin for 14 days, plus either the probiotic or a placebo.
LjubljanaAges 18 years+ - NCT01793168Recruiting
Rare disease registry and history study
This study keeps a registry (a structured list) of people with rare diseases and may also track how the condition changes over time. It can help researchers better understand rare illnesses and find gaps in care, which may improve future treatments.
Sioux Falls, South DakotaAges Any age - NCT06583395Enrolling by invitation
Meditation retreat study with fitness tracker
This trial studies people attending a 7-day meditation retreat to see how meditation affects well-being. You will wear a fitness tracker and answer surveys.
Palm Desert, CaliforniaAges 21 years+ - NCT03337932Recruiting
Shorter doxycycline course for multiple early Lyme skin rashes
This study looks at how long to take doxycycline for people who have multiple early Lyme disease skin rashes. It may help find the shortest effective treatment duration while keeping side effects low.
LjubljanaAges 18 years+ - NCT03418441Recruiting
Study infections of the brain and spinal fluid in Denmark
This trial focuses on people in Denmark who may have an infection in the brain or the fluid around the brain and spinal cord. Researchers aim to collect and compare diagnostic results for different infection types (viral meningitis, bacterial meningitis, encephalitis, and others) to help confirm the cause and guide care.
AalborgAges 18 years+ - NCT06045416Recruiting
Borrelia (Lyme) blood test study
This trial is testing a new blood test to help diagnose Lyme disease (borrelia infection) in children. If you are at the emergency room with symptoms that might be Lyme disease and you have a healthy immune system, you might be able to join.
ZurichAges 1 month–17 years - NCT06492668Recruiting
Tick exposure and prevention study for Alsace foresters
This study looks at how foresters in Alsace are exposed to ticks and tick-borne diseases, and how to prevent them. The goal is to better protect forestry workers from these risks.
Strasbourg, Les Hôpitaux Universitaires de StrasbourgAges 18 years+
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Lyme Disease trials by city
Studies with a site in or near these metro areas.
Lyme Disease trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for lyme disease?
- Yes. Clin2 currently lists 20 recruiting lyme disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a lyme disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a lyme disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.