Clinical trials · Massachusetts
Chronic pain clinical trials in Massachusetts
We’re tracking 42 recruiting chronic pain studies with a site in Massachusetts — including Phase 1/Phase 2 and Phase 2 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT04142177Recruiting
Test which pain treatments work best for chronic low back pain
This study compares how well different pain treatments reduce low back pain and improve daily life. You may be asked to start or continue care through the VA and attend in-person sessions while completing pain and activity questionnaires.
Boston, MassachusettsAges 18 years+ - NCT06466941Recruiting
Understanding acute pain after surgery
This study surveys surgical patients about their pain and emotional experience to better understand acute pain. You may help by answering questions or sharing your story.
Boston, MassachusettsAges 18 years+ - NCT07586397Recruiting
Hip Pain Treatment Study With Physical Activity Focus
This study tests a new approach to treating long-lasting hip pain that combines psychology and exercise. It's designed for people whose hip pain is affected by worry or stress, and who aren't as physically active as they'd like to be.
Boston, MassachusettsAges 18 years+ - NCT05304286Recruiting
Study of brain and pain in long-lasting post-surgery pain
This trial studies what’s happening in the brain and how pain is processed in people with pain that lasts long after surgery. It may help researchers understand chronic post-surgical pain and find better ways to treat it.
Boston, MassachusettsAges 12 years+ - NCT06690060Recruiting
Mind-body program for chronic migraine
This study tests whether a mind-body program, done remotely, can help people with chronic migraines reduce headache impact. It is for adults who have migraines at least 5 days a month and are willing to learn relaxation and stress-management techniques.
Boston, MassachusettsAges 18 years+ - NCT05684692RecruitingPhase 2
Pain-relief study for adults with schwannomatosis
This Phase 2 study tests whether an antibody medicine (either siltuximab or erenumab) can reduce moderate-to-severe pain in adults with schwannomatosis. It compares the medicine to a placebo and looks for improved pain control and tolerability.
Boston, MassachusettsAges 18 years+ - NCT07600203Recruiting
Low-level laser therapy for chronic jaw pain
This study tests whether a special laser device called the Erchonia EVRL can reduce chronic jaw pain caused by TMJ (temporomandibular joint) disorders. You would receive laser treatment and rate your pain over time to see if the laser helps more than a placebo.
Acton, MassachusettsAges 22–75 - NCT03984565RecruitingPhase 2
Study of a new cannabinoid for long-term body pain
This Phase 2 study tests how a new cannabinoid product affects people with ongoing musculoskeletal pain (like arthritis or injuries). It’s meant to see whether the product can improve pain for eligible adults who are not already using CBD regularly.
Belmont, MassachusettsAges 21 years+ - NCT06980948RecruitingPhase 1/Phase 2
Gene therapy study for nerve pain from small fiber neuropathy
This trial tests a new gene therapy called ST-503 for people with long-lasting nerve pain from small fiber neuropathy that hasn't improved with standard treatments. The study will check if the treatment is safe and tolerable.
Boston, MassachusettsAges 18 years+ - NCT07285018RecruitingPhase 2
Study of a new drug for diabetic nerve pain in legs
This trial tests an investigational drug for people with pain caused by nerve damage from diabetes (diabetic peripheral neuropathy). It may help reduce pain in your lower legs if other treatments haven't worked well.
New Bedford, MassachusettsAges 18 years+ - NCT04206215Recruiting
Noninvasive brain stimulation for carpal tunnel pain relief
This study tests whether a noninvasive brain stimulation treatment can reduce chronic carpal tunnel (CTS) pain, especially when pain spreads beyond the usual nerve area. If you have long-lasting CTS pain that hasn’t improved with standard treatments, you may be able to try this therapy while being closely monitored for safety.
Charlestown, MassachusettsAges 18–80 - NCT04379115Recruiting
Brain stimulation study for people with opioid addiction
This study tests a non-invasive brain stimulation approach to reduce opioid cravings in people who are actively using non-prescribed opioids while on stable methadone. It may help people feel less craving and improve recovery support.
Cambridge, MassachusettsAges 18–85 - NCT05661903RecruitingPhase 2
Spinal cord stimulator study for nerve pain and brain effects
This Phase 2 study looks at how spinal cord (or nerve-root) stimulation affects pain signals in the brain and body. You may qualify if you already have a stimulator set to a comfort mode that avoids “tingling” sensations.
Boston, MassachusettsAges 18–80 - NCT06350409Recruiting
Opioid use after surgery in teens
This study looks at how teens aged 12–17 use opioids after a scheduled surgery. It aims to understand outcomes and help improve pain management.
Boston, MassachusettsAges 12–17 - NCT07023523Recruiting
Controlling brain activity for chronic pain
This study tests if people with fibromyalgia can learn to control their own brain activity using real-time feedback from an MRI machine to reduce pain. It is designed to help those with long-term chronic pain find new ways to manage it.
Boston, MassachusettsAges 18–65 - NCT07336537Recruiting
Testing talk-based data collection software for chronic pain
This study tests easy-to-use talk-based software to collect health information from people with chronic pain. It may help researchers learn if tools like these are helpful for managing pain at home or in a lab.
Cambridge, MassachusettsAges 18 years+ - NCT07728695RecruitingPhase 1/Phase 2
Cannabis product for gynecologic pain study
This trial tests a new cannabis-based product to see if it helps with gynecologic pain (like endometriosis). It looks at how the product works and whether it is safe and effective.
Belmont, MassachusettsAges 21 years+ - NCT06095050Recruiting
Embolization for chronic shoulder pain
This trial tests a procedure called embolization to treat long-lasting shoulder pain that hasn't improved with other treatments like physical therapy or injections. The goal is to see if blocking certain blood vessels can reduce pain and improve function.
Boston, MassachusettsAges 21–80
Chronic pain trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting chronic pain studies listed above.
- Massachusetts General Hospital · 5 studies
- Brigham and Women's Hospital · 3 studies
- Beth Israel Deaconess Medical Center · 2 studies
- McLean Hospital · 2 studies
- Spaulding Rehabilitation Hospital · 2 studies
- Acton Dental Associates
- Athinoula A. Martinos Center for Biomedical Imaging
- Boston Children's Hospital
What taking part in a chronic pain study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Chronic pain trials in other states
Common questions
- Are there chronic pain clinical trials in Massachusetts?
- Yes. We're currently tracking 42 recruiting chronic pain studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a chronic pain study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a chronic pain trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New chronic pain studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.