Clinical trials
Chronic Periodontitis clinical trials
Below are recruiting chronic periodontitis clinical trials, each written for real people, not researchers. We’re tracking 18 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07293962RecruitingPhase 2
Liquid S-PRF for gum disease treatment
This study tests whether a special liquid made from your own blood (called liquid S-PRF) can improve gum health during deep cleaning for people with advanced gum disease. It lasts 3 months and may help reduce inflammation and promote healing without surgery.
Jenjarum, SelangorAges 18–65 - NCT07069881Recruiting
Comparing two dental cleaning methods for chronic root infection
This trial compares two ultrasonic cleaning methods (regular vs. passive) for treating a chronic tooth infection called chronic apical periodontitis. It aims to see which approach is more effective at clearing the infection and saving the tooth.
Guangzhou, GuangdongAges 18–59 - NCT02833285Recruiting
Study immune cells in people with gum disease
This study looks at how the immune system (B cells) works in gum disease and may help doctors better understand the condition. You may be asked to take part if you need gum surgery and meet other health and treatment rules.
BrestAges 18–75 - NCT07452640Recruiting
Comparing two non-surgical gum treatments for advanced periodontitis
This study compares two methods for treating advanced gum disease (periodontitis) without surgery: one uses a special ultrasound device (Vector® system) and the other uses small hand tools (Mini-Five curettes). The goal is to see which cleans deeper pockets better and helps gums heal.
AnkaraAges 18–65 - NCT07711431Recruiting
Connection between gum disease and ongoing neck pain
This study looks at whether there is a link between gum (periodontal) disease and long-term neck pain without a clear cause. If you are between 30 and 55, have most of your own teeth, and don't take regular pain medicine, you may be able to help doctors understand this connection.
Niğde, Niğde ProvinceAges 30–55 - NCT06895980Recruiting
Gum treatment for better blood sugar in diabetes
This trial tests whether treating gum disease can help improve blood sugar control in people with type 2 diabetes. If you have poorly controlled diabetes and gum disease, you may be able to join this study.
Santiago, ProvidenciaAges 18 years+ - NCT07262606Recruiting
Saliva protein levels in gum disease severity and smoking
This study looks at a protein called Mitofusin-1 in your saliva to see if its levels are linked to how serious gum disease is, whether you smoke, and how you respond to treatment. Samples will be taken once before any treatment begins.
Erzincan, ErzincanAges 18–65 - NCT07312045Recruiting
Gum health and healing after non-surgical treatment
This study looks at how certain blood and saliva measurements relate to gum disease and healing after a deep cleaning. It may help find better ways to track gum health.
Merkez, ErzincanAges 18–65 - NCT06692582Recruiting
Saltwater rinse for treating gum disease
This study tests whether rinsing your mouth with a special saltwater solution (electrolyzed water) can help treat gum disease. It's for people who have advanced gum disease and want to try a simple, gentle addition to regular care.
LjubljanaAges 18–80 - NCT05924373RecruitingPhase 2
Stem cell treatment for chronic gum disease defects
This Phase 2 trial studies whether injections of human dental pulp stem cells can improve chronic periodontitis (long-term gum disease) by helping repair damaged bone around teeth. If you have a specific type of bone defect and moderate gum pocket depth, you may be eligible and could benefit from a novel regenerative approach.
Beijing, BeijngAges 18–65 - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT06978712Recruiting
Gum inflammation and body stress link study
This study checks if gum inflammation (periodontitis) affects your body's stress system (allostatic load). It aims to find a link between severe gum disease and overall health stress.
Rohtak, HaryanaAges 30–50 - NCT07487272Recruiting
Cell mapping in gum disease tissues
This study looks at the cells in gum tissue from people with different types of periodontitis (aggressive or chronic) and healthy gums. By understanding which cells are active and how they interact, researchers hope to find better ways to diagnose or treat gum disease.
Hangzhou, ZhejiangAges 20–40 - NCT06373848Enrolling by invitation
Vitamin E and Coenzyme Q10 for early gum disease
This study tests whether adding vitamin E and coenzyme Q10 to standard gum treatment can help heal early-stage chronic gum disease. It is for otherwise healthy adults aged 28-35 with mild gum pockets on their lower molars.
TehranAges 28–40 - NCT07059481Recruiting
Root canal sealers and oxidative stress study
This study is looking at how different types of root canal filling materials (sealers) affect oxidative stress markers in the body. It is for people with a single tooth that has a chronic infection at the root tip and needs a root canal.
Ordu, Ordu- AltınorduAges 18–45 - NCT06587048Recruiting
New bone window surgery for root canal infections
This trial tests a new way to perform root-end surgery using a special ultrasound device. It aims to treat infections at the tip of a tooth root by making a small opening in the bone, which may help you heal faster.
Rohtak, HaryanaAges 18–60 - NCT07388901Recruiting
Comparing two root canal sealers for infection treatment
This trial compares two materials (iRoot SP and nRoot SP) used to fill root canals after infection. It aims to see which works better for healing apical periodontitis, an infection around the tooth root.
Hangzhou, ZhejiangAges 18 years+ - NCT07491848Recruiting
Mouth health study for hepatitis B and D patients
This study looks at mouth health in people with hepatitis B and D, including those taking a medicine called bulevirtide and those not taking it. It may help understand how these infections affect the mouth and gums.
CraiovaAges 18 years+
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Common questions
- Are there clinical trials for chronic periodontitis?
- Yes. Clin2 currently lists 18 recruiting chronic periodontitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a chronic periodontitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a chronic periodontitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.