Clinical trials
Periodontitis (Stage 3) clinical trials
Below are recruiting periodontitis (stage 3) clinical trials, each written for real people, not researchers. We’re tracking 21 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07770256Recruiting
Bone regeneration surgery for lower molar gum disease
This study looks at the shape of lower molar teeth with a certain type of gum disease and tests a surgical treatment to help regrow the bone around those teeth. If you have advanced gum disease and a lower molar with a specific type of bone loss, this treatment might help save the tooth.
Ho Chi Minh CityAges 18 years+ - NCT07673185Recruiting
Omega-3 and low-dose aspirin for gum disease in smokers
This trial tests whether taking omega-3 supplements with low-dose aspirin can improve gum health in smokers with advanced gum disease (stage III periodontitis). It aims to see if this combination safely reduces gum pocket depth and tissue damage.
CairoAges 30–50 - NCT06967402Recruiting
Mouthwash study for gum disease treatment
This study tests two types of mouthwash to see which helps treat gum disease better when used with regular dental care. It may be a good option if you have moderate to severe gum disease and are generally healthy.
Hong KongAges 18 years+ - NCT07293962RecruitingPhase 2
Liquid S-PRF for gum disease treatment
This study tests whether a special liquid made from your own blood (called liquid S-PRF) can improve gum health during deep cleaning for people with advanced gum disease. It lasts 3 months and may help reduce inflammation and promote healing without surgery.
Jenjarum, SelangorAges 18–65 - NCT07443410Recruiting
Probiotics for gum disease treatment
This trial tests whether taking pre- and probiotics alongside non-surgical gum treatment improves healing and reduces harmful bacteria. It may help people with advanced gum disease (stage III or IV periodontitis).
Heidelberg, Baden-WurttembergAges 18 years+ - NCT07599657Recruiting
Protein Levels in Gum Disease Before and After Minimally Invasive Surgery
This study measures a natural protein in your gums before and after a minimally invasive surgical treatment for moderate to advanced gum disease. Researchers want to understand how this protein changes with treatment, which may help improve gum disease care in the future.
CairoAges 18 years+ - NCT06980714Enrolling by invitation
Electric vs. manual toothbrush for advanced gum disease
This study compares electric and manual toothbrushes to see which one works better for people with advanced gum disease (stage 3 or 4 periodontitis). It might help you find a more effective way to care for your teeth and gums at home.
L’AquilaAges 18 years+ - NCT07671963Recruiting
Bone Graft Options for Gum Disease Surgery
This trial tests two bone-replacement materials (a synthetic bone substitute and a natural bone graft) placed during gum surgery to see which one better helps rebuild bone and gum support around teeth with deep pockets.
Cagliari, ItalyAges 18–80 - NCT07368699Recruiting
Gum disease treatment with oxygen gel and light therapy
This trial tests a new gel that releases oxygen combined with a special light treatment to help heal advanced gum disease. It might help if standard treatments haven't been enough.
Alexandria, Bab SharqAges 30–70 - NCT06699654Enrolling by invitation
Spirulina gel for gum disease treatment
This trial tests if a gel made from spirulina can help treat mild-to-moderate gum disease (periodontitis). You may be a good fit if your gum disease is at a specific stage and you are otherwise healthy.
El-Sheikh Zayed City, Cairo GovernorateAges Any age - NCT06914596Recruiting
Comparing an at-home gum treatment to standard care after deep cleaning
This study tests if a device you use at home for 30 minutes twice a day can improve gum healing after a deep cleaning (scaling and root planing). Participants will have their gum health compared to a group that receives standard care.
Fullerton, CaliforniaAges 30–75 - NCT06624241Recruiting
Curcumin gel plus deep cleaning for Stage III gum disease
This trial tests a new gel made from curcumin (a natural substance found in turmeric) combined with a standard deep cleaning treatment for Stage III gum disease. The goal is to see if the gel helps reduce gum inflammation and improve healing.
Chieti, CHAges 18–80 - NCT07754253RecruitingPhase 1
Green tea extract for gum disease treatment
This trial tests a green tea extract (EGCG) as an add-on to standard gum disease treatment, delivered locally to the gums. It aims to see if this natural compound can help improve gum health more effectively than standard care alone.
Al Mansurah, Dakahlia GovernorateAges 25–60 - NCT07263113Recruiting
Gum disease and heart health study
This study looks at whether severe gum disease (periodontitis) is linked to stiffer arteries and higher heart risk. If you have advanced gum disease or healthy gums, you may be able to join to help researchers understand this connection.
NantesAges 40–69 - NCT07316023RecruitingPhase 2
Light therapy for gum disease treatment
This trial tests a new light treatment for gum disease using a special dye that targets and kills harmful bacteria. It may help if you have advanced gum disease and haven't had treatment recently.
CairoAges 36–50 - NCT07459049RecruitingPhase 4
Ibuprofen for gum inflammation after deep cleaning
This trial tests whether ibuprofen can help calm gum inflammation after a deep cleaning for periodontitis. It is for adults with moderate-to-severe gum disease who are otherwise healthy.
BaghdadAges 18 years+ - NCT07316582Enrolling by invitationPhase 4
Melatonin gel for gum disease treatment
This trial tests a new gel made with melatonin and platelet-rich fibrin to treat gum disease. It may help reduce pocket depth and improve gum health without surgery.
New CairoAges 20–60 - NCT06068270Recruiting
MOPs cleaning aid for gum disease patients getting braces
This trial tests whether a special type of oral hygiene device (called MOPs) helps protect teeth and gums during orthodontic treatment (braces or aligners) in people with severe gum disease (stage IV periodontitis). It may help prevent further damage and improve the success of moving teeth.
Madrid, MadridAges 18–80 - NCT06726902Enrolling by invitation
Comparing air polishing powders for gum disease treatment
This trial tests whether different air polishing powders improve nonsurgical gum disease treatment in people with moderate to severe periodontitis. It aims to find a better way to clean below the gum line without surgery.
AlexandriaAges 30–65 - NCT06789458Recruiting
Pro-resolution mediators in severe gum disease before and after treatment
This study looks at natural substances in your blood that help reduce gum inflammation. Researchers want to see how these substances change after standard gum disease treatment, which may lead to better ways to manage severe periodontitis.
Manial, Cairo GovernorateAges 18–80 - NCT07725393Recruiting
Pomegranate gel for moderate to advanced gum disease
This study tests a gel made from pomegranate peel extract placed under the gums, along with standard deep-cleaning treatment, for people with moderate to advanced gum disease. It may help reduce gum inflammation and pocket depth naturally.
Cairo, Cairo GovernorateAges 30–60
Hear when a new Periodontitis (Stage 3) trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for periodontitis (stage 3)?
- Yes. Clin2 currently lists 21 recruiting periodontitis (stage 3) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a periodontitis (stage 3) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a periodontitis (stage 3) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.