Clinical trials
Circulating Tumor DNA clinical trials
Below are recruiting circulating tumor dna clinical trials, each written for real people, not researchers. We’re tracking 88 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07698535RecruitingPhase 2
Blood test to guide early stopping of prostate cancer therapy
This trial uses a blood test to measure tumor DNA and see if men with advanced prostate cancer can safely stop treatment with a drug called 177Lu-PSMA-617 earlier than usual, or switch to chemotherapy. It may help reduce side effects while still controlling the cancer.
Seattle, WashingtonAges 18 years+ - NCT04824950Recruiting
Blood DNA test in newly diagnosed mediastinal large B-cell lymphoma
This study looks at how “circulating tumor DNA” in blood changes in people with newly diagnosed primary mediastinal large B-cell lymphoma. It may help doctors better monitor treatment response alongside standard PET/CT-guided care, which could improve follow-up decisions.
LyonAges 18 years+ - NCT05601505RecruitingPhase 2
DNA blood test–guided treatment before rectal cancer surgery
This trial uses a special DNA blood test (circulating tumor DNA) to help guide chemotherapy and radiation before surgery for locally advanced rectal cancer. It aims to improve outcomes by tailoring treatment based on the DNA signals from the tumor.
Beijing, Beijing MunicipalityAges 18–75 - NCT05904665Recruiting
Blood methylation test to guide follow-up after colon cancer surgery
This study checks a special blood test (circulating tumor DNA methylation) to help guide follow-up after surgery for non-metastatic colon cancer. It may help find whether additional treatment or closer monitoring is needed based on the test results.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT05889247Recruiting
Blood test guided monitoring for advanced lung cancer treatment
This trial checks whether a blood test that looks for cancer DNA can help guide and monitor treatment in people with advanced non-small cell lung cancer (NSCLC). It may help your team spot treatment response or changes earlier, so care can be adjusted appropriately.
Hillerød, Region HAges Any age - NCT06606366Recruiting
Genetic tumor testing using a blood test to guide treatment
This study uses a simple blood test to look at the genetic makeup of your tumor. The results may help your doctors choose the best treatment for you. You will need to provide a tumor sample or have a biopsy.
NiceAges 18 years+ - NCT04530890Recruiting
Testing blood tumor DNA in digestive and breast cancers
This study looks at a blood test for “circulating tumor DNA” (tiny pieces of cancer-related DNA in the blood). It may help doctors learn more about digestive, gynecologic, or breast cancers and how patients respond when treatment like chemotherapy or immunotherapy is needed.
PoitiersAges 18 years+ - NCT04782557Recruiting
Ultrasound-guided blood sampling to track cancer DNA
This study uses an ultrasound-guided procedure to collect blood and check for cancer DNA (small bits of tumor material in the bloodstream). It aims to see whether this method can better track how gastric, pancreatic, or colorectal cancer responds to treatment.
Hong KongAges Any age - NCT05375370Recruiting
Testing a blood test to predict liver cancer coming back
This study checks whether a blood test (circulating tumor DNA) can help predict if hepatocellular carcinoma (HCC) will return after curative treatment like surgery or ablation. If it works, it may help doctors plan closer follow-up or earlier treatment if recurrence risk is higher.
RouenAges 18 years+ - NCT05529615Recruiting
Blood DNA test guides chemotherapy after colon cancer surgery
This trial checks a blood test called circulating tumor DNA to help choose the best time and approach for chemotherapy after colon cancer surgery. It aims to reduce recurrence by identifying people who may benefit from treatment based on changes seen in the blood.
Beijing, Beijing MunicipalityAges 18–75 - NCT05598528Recruiting
Study why some lung cancers don’t respond to EGFR pills
This study looks at why certain EGFR-positive advanced lung cancers resist third-generation EGFR tablet treatment given as the first treatment. Your body samples and scan results help researchers understand the resistance, which may guide better future care.
Changsha, HunanAges 18 years+ - NCT05954078RecruitingPhase 3
ctDNA-guided chemotherapy after colon cancer surgery
This trial checks whether a special blood test (ctDNA methylation) can help decide the best chemotherapy after surgery for people at higher risk of colon cancer coming back. It may help spare some patients unnecessary treatment while aiming to improve outcomes for those likely to relapse.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT06088381RecruitingPhase 2
HPV-related throat cancer treatment based on tumor DNA levels
This trial tests if monitoring cancer DNA left in your blood after surgery can help decide if you need additional treatment. It is for people with HPV-positive oropharynx (throat) cancer who have a certain amount of cancer DNA detected before surgery.
Baltimore, MarylandAges 18 years+ - NCT06434896Recruiting
Blood test to guide chemotherapy in stage II colon cancer
This trial is for people with stage II colon cancer who are not currently getting chemotherapy. It uses a blood test to look for tumor DNA, so doctors can decide if chemotherapy might help prevent the cancer from coming back.
's-HertogenboschAges 18 years+ - NCT06495554Recruiting
Danish vulva cancer recurrence study
This study looks at how vulva cancer returns (recurrence) over time. It aims to improve follow-up care for people who have had this type of cancer.
Aarhus NAges 18 years+ - NCT06666439Recruiting
Tracking lobular breast cancer with a blood test
This study is testing a new blood test that looks for cancer DNA to track how lobular breast cancer responds to treatment. It is for people whose cancer has spread and who have not yet started treatment for the spread.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07310537Recruiting
Liquid biopsy trial for colorectal cancer liver metastases
This study tests whether a simple blood sample from your finger can detect tumor DNA as well as a standard blood draw. It is designed for people with colorectal cancer that has spread to the liver and hasn't responded to treatment.
Rotterdam, South HollandAges 21 years+ - NCT07517107RecruitingPhase 2
Blood tests to guide gastric cancer treatment decisions
This study uses special blood tests to detect cancer DNA and help doctors decide the best treatment plan for gastric cancer. The goal is to improve outcomes by personalizing therapy based on how your cancer responds.
ShanghaiAges 18 years+ - NCT06653062Recruiting
Blood test to watch for liver cancer return
This trial studies a new blood test that looks for DNA from cancer cells' mitochondria to see if it can catch liver cancer coming back earlier. The goal is to help doctors find recurrence faster and improve follow-up care.
Wuhan, HubeiAges 18 years+ - NCT03551951Recruiting
Testing cancer cells and DNA in blood, urine, and bone marrow
This study looks for cancer-related cells and DNA in samples like blood, urine, and (for some) bone marrow. The goal is to see whether these tests can help detect or track solid cancers with minimal added procedures.
Columbia, MissouriAges 18 years+ - NCT06653127Recruiting
Using a blood test to watch for biliary tract cancer return
This trial studies a new blood test that looks for bits of tumor DNA (ct-mtDNA) to see if it can detect if biliary tract cancer has come back earlier than standard scans. The test might help doctors monitor for recurrence more closely.
Wuhan, HubeiAges 18 years+ - NCT03818412Recruiting
Liquid biopsy for soft tissue sarcoma
This study checks if a blood test can detect DNA from soft tissue sarcomas. The goal is to see if circulating tumor DNA can help doctors monitor the disease and plan treatment.
Toronto, OntarioAges 18 years+ - NCT04354064Recruiting
Blood DNA test to see early treatment response in solid tumors
This study looks at circulating tumor DNA, which is tiny bits of DNA found in blood, to help assess how solid tumors are responding early. It uses blood samples from healthy adults who are willing to donate.
St Louis, MissouriAges 18 years+ - NCT07401316Recruiting
Tracking germ cell tumors with a blood test for cancer DNA
This trial looks for signs of cancer DNA in your blood (circulating tumor DNA) to see if it can help track germ cell tumors. It may help doctors find out if your cancer is coming back earlier.
Indianapolis, IndianaAges 18 years+
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Common questions
- Are there clinical trials for circulating tumor dna?
- Yes. Clin2 currently lists 88 recruiting circulating tumor dna studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a circulating tumor dna trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a circulating tumor dna trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.