Clinical trials
Cocaine Use Disorder clinical trials
Below are recruiting cocaine use disorder clinical trials, each written for real people, not researchers. We’re tracking 70 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06189690Recruiting
Brain stimulation study for cocaine addiction
This trial tests whether a non-invasive brain stimulation technique called high-frequency repetitive transcranial magnetic stimulation (HF rTMS) can help reduce cocaine cravings and change brain chemistry. It may be a good option if you have cocaine use disorder and want to explore a new treatment that doesn't involve medication.
Mexico City, TlalpanAges 18–50 - NCT07829263Recruiting
Brain stimulation with talk therapy for cocaine use disorder
This study tests whether a non-invasive brain stimulation method (high-definition transcranial direct current stimulation, or HD-tDCS) combined with cognitive behavioral therapy (a type of talk therapy) can help people reduce cocaine use. It explores if this combination is safe and practical.
Richmond, VirginiaAges 18–65 - NCT07773649RecruitingEarly Phase 1
PET scan to study energy use in brain of people with cocaine use disorder
This study uses a special PET scan to look at how brain cells make energy, which may be changed by cocaine. It might help researchers find better ways to treat cocaine use disorder.
Pittsburgh, PennsylvaniaAges 18–45 - NCT07693608Enrolling by invitationPhase 2
Tirzepatide for weight loss in stimulant use disorder
This trial tests whether a weekly injection called tirzepatide (a diabetes and weight-loss medication) can help people with obesity and stimulant use disorder reduce stimulant use and lose weight. It aims to see if treating both conditions together improves outcomes.
Dallas, TexasAges 18–65 - NCT07624227RecruitingPhase 1/Phase 2
Cobenfy Maintenance Effects on Cocaine Use Disorder
This study tests whether a medication called Cobenfy can reduce cocaine's effects in people with cocaine use disorder. Researchers will monitor your health and test how the medication impacts your response to cocaine.
Lexington, KentuckyAges 18–60 - NCT06701487Recruiting
Brain learning mechanisms and substance use control
This study looks at how certain learning mechanisms in the brain (called Pavlovian conditioning) influence your ability to control alcohol or drug use. It may help explain why some people have trouble stopping, and could lead to better treatments. You'll fill out questionnaires and likely have a brain scan (MRI).
DresdenAges 18–65 - NCT06125054RecruitingPhase 2
Ketamine and brain training for cocaine addiction
This trial tests whether a combination of ketamine (a medicine that may help the brain change) and neurofeedback training (a brain-exercise technique) can help people with cocaine addiction. The goal is to see if these treatments can improve brain flexibility and reduce cravings.
Zurich, Canton of ZurichAges 18–55 - NCT07532460Recruiting
Study of brain channels and memory in cocaine users
This research explores how certain brain chemicals (potassium channels) affect memory and thinking in people who use cocaine regularly. The study may help develop better treatments for cocaine use disorder and related thinking problems.
Zurich, Canton of ZurichAges 20–50 - NCT07490600Recruiting
Testing brain stimulation and rewards for quitting cocaine
This trial combines deep transcranial magnetic stimulation (TMS) with a reward program (contingency management) to help people stop using cocaine. It may help if you are struggling with moderate to severe cocaine use and want a non-drug treatment.
Houston, TexasAges 18–65 - NCT07318480Recruiting
Brain stimulation for drug addiction
This study tests a type of brain stimulation (called tDCS) to help people reduce their use of stimulants (like crack/cocaine) or opioids. It might help lessen cravings and improve treatment outcomes.
New York, New YorkAges 18–60 - NCT07313371RecruitingPhase 4
Clonidine for reducing cravings in cocaine and crack users
This trial tests whether the medication clonidine can help reduce cravings for people hospitalized with cocaine or crack use disorder. You must be staying in a specific hospital ward and be able to take pills by mouth.
São Paulo, São PauloAges 18–65 - NCT07221396Enrolling by invitation
A text-based program to help reduce stimulant use
This study tests a text-message program called LDART to help people who use cocaine or other stimulants cut down or quit. If you live in Connecticut, have a smartphone, and want to reduce your stimulant use, you may be able to join.
New Haven, ConnecticutAges 18 years+ - NCT07227948RecruitingPhase 2
Testing semaglutide for cocaine use disorder
This study tests whether semaglutide, a medication used for weight management, can help reduce cocaine use in people with cocaine use disorder. You may qualify if you have a body mass index (BMI) of 25 or higher and recently used cocaine.
Houston, TexasAges 18 years+ - NCT05986578Recruiting
Brain stimulation for cocaine use disorder
This study tests whether brain stimulation can help people with cocaine use disorder. It is a research study that aims to identify brain targets for treatment with a non-invasive technique called transcranial magnetic stimulation (TMS).
Houston, TexasAges 18–65 - NCT07119567Recruiting
Cocaine use and withdrawal effects on sleep
This study looks at how cocaine use and stopping cocaine affect sleep. It may help people with cocaine use disorder who are planning to detox in a hospital.
Bron, AURAAges 18 years+ - NCT07086794RecruitingEarly Phase 1
Testing if pentoxifylline helps reduce cocaine use
This study tests whether a medication called pentoxifylline can reduce cocaine use in people who smoke or inject cocaine but aren't ready to stop. You'll receive either pentoxifylline or a placebo to see if it helps control cravings or use.
Lexington, KentuckyAges 18–55 - NCT07071779Recruiting
Online training to help young people resist alcohol or cocaine
This study tests a web-based training program to help teens and young adults (ages 14–35) improve their ability to say no to alcohol or cocaine. The training could make it easier to resist cravings during treatment.
BernAges 14–35 - NCT07033416Recruiting
Training to reduce cocaine cravings
This trial tests a computer training program that helps people with cocaine use disorder change their automatic reactions to drug cues. The goal is to see if this training can reduce cravings and improve treatment outcomes.
Milan, MilanoAges 18 years+ - NCT05974202Recruiting
Brain stimulation and therapy for cocaine use
This study tests a combination of brain stimulation (rTMS) and talk therapy (CBT) to help people reduce cocaine use. It's for adults who want treatment and use cocaine at least once a week.
New York, New YorkAges 22–65 - NCT05529927RecruitingPhase 2
Dexamphetamine given long-acting to reduce cocaine use
This Phase 2 study tests whether a long-acting form of dexamphetamine can reduce cocaine use in people with moderate to severe cocaine use disorder. It also checks safety, including heart and mental health side effects, while you attend study visits regularly.
The HagueAges 18 years+ - NCT05138614Recruiting
Help for people with opioid use disorder and mental health needs
This trial studies a program meant to improve treatment access and support recovery for people with opioid use disorder who also have mental health symptoms. It may help if you are new to the program or recently relapsed, or if mental health symptoms have worsened—even without a relapse.
Holyoke, MassachusettsAges 18 years+ - NCT05011760RecruitingEarly Phase 1
PET brain scan with a cocaine-use disorder medicine test
This early-phase study uses a PET brain scan (a special imaging test) to see how the brain responds in people with cocaine use disorder. It aims to better understand brain activity and whether this scan approach could help research or future treatments.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07825818RecruitingEarly Phase 1
Brain scan study for heavy drinkers
This study uses a special brain scan to look at how alcohol use affects energy production in brain cells. It may help researchers find new ways to treat alcohol use disorder.
Pittsburgh, PennsylvaniaAges 18–55 - NCT07735585Recruiting
App-based support for alcohol use disorder
This study tests a smartphone app that uses rewards to help people reduce or stop drinking. You may be eligible if you have alcohol use disorder and are seeking treatment at a specific clinic in São Paulo.
São Paulo, São PauloAges 18–70
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Cocaine Use Disorder trials by city
Studies with a site in or near these metro areas.
Cocaine Use Disorder trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for cocaine use disorder?
- Yes. Clin2 currently lists 70 recruiting cocaine use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cocaine use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cocaine use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.