Clinical trials
Cognition clinical trials
Below are recruiting cognition clinical trials, each written for real people, not researchers. We’re tracking 1,981 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05495087Recruiting
Breathing low-oxygen air to test brain benefits in mild memory loss
This study tests whether breathing controlled low-oxygen air (through a disposable face mask) can improve brain function in people with mild cognitive impairment (MCI). You’d be randomly assigned to the real treatment or a sham (placebo-like) control, and you’d need multiple lab visits.
Fort Worth, TexasAges 55–79 - NCT05480982Recruiting
Cognitive functional therapy versus Pilates for low back pain
This study compares two exercise-based approaches—cognitive functional therapy and Pilates—to help reduce chronic low back pain in older adults. It may help by improving how you move and manage pain, not just stretching muscles.
Rio de Janeiro, Rio de JaneiroAges 65 years+ - NCT05117255Recruiting
Online therapy study for anxiety in residential alcohol treatment
This study tests an internet-based, interactive version of cognitive behavioral therapy (CBT) for anxiety symptoms. It’s designed for people getting mainly alcohol-focused treatment in a residential program, to see if the online approach works and is feasible for you.
Minneapolis, MinnesotaAges 18–65 - NCT05448768Enrolling by invitation
Testing brain stimulation in people with mild memory problems
This study tests a brain stimulation approach (TBS) to see if it can improve thinking and memory in people with mild cognitive impairment. It may also explore why it works by looking at brain-related measurements after TBS.
TaoyuanAges 50–90 - NCT05456321Recruiting
Brain stimulation and thinking training for prenatal alcohol effects
This study tests whether brain stimulation plus structured thinking practice can improve thinking and brain function in people affected by heavy alcohol exposure before birth. It may help parents and researchers learn how to support learning and daily functioning in fetal alcohol spectrum disorders.
Minneapolis, MinnesotaAges 8–17 - NCT05445180Recruiting
Brain scan study of thinking in cannabis users with psychosis
This study uses brain imaging to understand how thinking works in people who use cannabis, comparing those with psychosis to people without psychosis. It may help researchers learn what brain patterns relate to thinking difficulties and how cannabis use fits in.
Montreal, QuebecAges 16–80 - NCT05375513Recruiting
Home-based program to boost memory and thinking
This study tests a program that combines exercise, diet advice, and memory training, all done from home, to help improve thinking and memory in older adults with mild memory problems. You'll be asked to use a computer or tablet for virtual sessions and follow a simple plan.
Edmonton, AlbertaAges 60–85 - NCT05371483Enrolling by invitation
Study effects of narcolepsy and hypersomnia treatments on brain and heart
This study looks at how narcolepsy or idiopathic hypersomnia affects thinking and cardiovascular health, and how usual treatment medications may change those outcomes. It may help researchers understand risks and benefits of common hypersomnia therapies.
Scottsdale, ArizonaAges 18–75 - NCT05396248Recruiting
Memory training study for older adults with mild memory problems
This trial tests an approach to improve learning and memory in people age 60+ with amnestic mild cognitive impairment (a specific type of early memory problem). It may help by supporting memory and learning skills, but it also has medication and health-history requirements.
Ann Arbor, MichiganAges 60 years+ - NCT05355389Recruiting
Home online rehab to improve thinking and movement in MS
This study tests whether doing cognitive-and-movement rehabilitation at home through telehealth helps people with multiple sclerosis (MS). It likely looks at changes in thinking performance and physical function while also checking safety with brain and electrical tests.
BrusselsAges 18–65 - NCT05273125Recruiting
Testing mobility and thinking in people with mild cognitive problems
This study looks at how well people with mild cognitive problems can think and move, using brief learning/thinking tests and a walking task. It may help researchers understand changes early enough to guide future care.
LilleAges 65 years+ - NCT05282550RecruitingPhase 2
Trazodone trial to improve sleep in early Alzheimer’s
This study tests whether the sleep medicine trazodone can improve thinking and memory in people with early Alzheimer’s-related changes who also have sleep problems. If better sleep helps the brain, it may improve memory test results over time.
Baltimore, MarylandAges 55 years+ - NCT04583800Recruiting
Tracking heart failure risk and memory change in diabetes
This study follows adults with type 2 diabetes to see who may develop heart problems and who may have memory or thinking changes over time. It may help doctors better predict risk and plan earlier support.
LilleAges 18 years+ - NCT05254015Enrolling by invitation
Therapy for hoarding symptoms in adults 50+
This trial tests a combined therapy approach (cognitive rehabilitation plus exposure therapy) to reduce hoarding behaviors in older adults. You may benefit if your hoarding is your main diagnosis and your symptoms and medications are stable.
San Diego, CaliforniaAges 50 years+ - NCT05215353RecruitingPhase 4
Music therapy or talk therapy for anxiety after cancer
This study compares music therapy and cognitive behavioral therapy (CBT) to see which better reduces anxiety in people who have had cancer. You may be randomly assigned to one of the two therapy programs and will join sessions by video call.
Miami, FloridaAges 18 years+ - NCT05138588Recruiting
rTMS for thinking ups and downs in Lewy body dementia
This study tests whether repeat rTMS sessions can improve thinking “fluctuations” (noticeable ups and downs) in people with Lewy body dementia. It’s a proof-of-concept trial, meaning it’s mainly to see if the approach is feasible and potentially helpful.
StrasbourgAges 45 years+ - NCT05195398Recruiting
Brain stimulation to improve thinking after stroke
This study tests whether a noninvasive brain stimulation treatment can improve thinking and memory problems after an acute ischemic stroke. It also uses brain scans to better understand how the treatment may help.
Baltimore, MarylandAges 18–100 - NCT05144516Recruiting
Video support program for cancer and mild memory problems
This study tests a video-based, “dyad” (patient plus family caregiver) coaching program for people with cancer and mild memory trouble (mild cognitive impairment). It may help by improving coping and communication during cancer care.
Durham, North CarolinaAges 18–100 - NCT04949360Recruiting
Digital CBT-i program for insomnia using a tablet
This trial tests a phone or tablet app-based program based on CBT-i, a structured therapy that helps improve sleep habits and reduce insomnia symptoms. It may help if you have ongoing insomnia and prefer a digital approach.
São Caetano do Sul, São PauloAges 20–60 - NCT05090267Recruiting
Gut-brain treatments for alcohol use and memory changes
This study tests whether gut-brain–targeted treatments (including probiotics and stimulation of a nerve) can improve thinking and inflammation-related health in people who use alcohol. You may be able to join if you have memory/thinking problems and meet specific medical limits, including HIV immune system levels.
Coral Gables, FloridaAges 35–70 - NCT05081596Recruiting
Primary care program for mood and thinking in early Alzheimer’s
This trial tests a psychosocial (talk/behavior/support) program delivered through primary care to improve thinking and depression symptoms in older adults with mild cognitive problems and early Alzheimer’s. It may help if you have early memory/thinking changes plus mild depressive symptoms and you can work with a caregiver or study partner.
White Plains, New YorkAges 60 years+ - NCT05132517Recruiting
Magnesium to support thinking after stroke
This trial studies whether magnesium can help improve or protect thinking skills after a stroke. It may be offered to people who did not already have memory or thinking problems before their stroke.
Hessisch Oldendorf, Lower SaxonyAges 18 years+ - NCT05036538Recruiting
Reducing pre-surgery stress to help prevent confusion after heart surgery
This study tests whether a stress-reducing relaxation method before heart surgery can lower the risk of postoperative delirium (sudden confusion) and longer-term thinking problems. It may help you keep clearer thinking in the days and weeks after surgery.
Bad Nauheim, HesseAges 18 years+ - NCT05062369Recruiting
Brain stimulation plus training to support alcohol abstinence
This study tests whether a combination of brain stimulation (tDCS) and cognitive training can help people with alcohol use disorder stay abstinent. You may be included if you are currently not drinking and can commit to the program timeline.
Minneapolis, MinnesotaAges 18–65
Hear when a new Cognition trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for cognition?
- Yes. Clin2 currently lists 1,981 recruiting cognition studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognition trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognition trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.