Clinical trials
Cognitive Impairment clinical trials
Below are recruiting cognitive impairment clinical trials, each written for real people, not researchers. We’re tracking 571 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06321588Recruiting
Autoimmune dementia: predicting antibodies in new cognitive decline
This study looks for certain antibodies that might be causing your new memory or thinking problems. It aims to find patterns that could help diagnose autoimmune dementia earlier.
Bologna, BolognaAges 40–90 - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT05948930Recruiting
Exercise and brain training for mild memory problems
This study tests whether a mix of physical exercise and computer brain training can improve working memory in people with mild cognitive impairment (MCI). It may help by strengthening memory skills and supporting brain health through supervised activity and computer-based practice.
Baltimore, MarylandAges 50–80 - NCT05877196Recruiting
Adaptive walking and fitness program for mild memory decline
This study tests an “adaptive” exercise plan that adjusts over time to help improve aerobic fitness and your body’s fitness response in people with mild memory problems or early Alzheimer’s. It may help you safely build the kind of fitness that supports brain health, while researchers monitor changes with fitness testing and blood work.
Phoenix, ArizonaAges 65 years+ - NCT05790707Recruiting
Ablation for persistent atrial fibrillation to help memory
This study checks whether a procedure called atrial fibrillation ablation can slow memory problems in people who already have mild cognitive impairment. Participants will be tested on thinking and memory before and after treatment to see if the procedure helps.
AngersAges 60–80 - NCT05495087Recruiting
Breathing low-oxygen air to test brain benefits in mild memory loss
This study tests whether breathing controlled low-oxygen air (through a disposable face mask) can improve brain function in people with mild cognitive impairment (MCI). You’d be randomly assigned to the real treatment or a sham (placebo-like) control, and you’d need multiple lab visits.
Fort Worth, TexasAges 55–79 - NCT05446584RecruitingPhase 2
Study memory changes in people with past mild head injury
This Phase 2 study looks at how memory problems (amnestic mild cognitive impairment) may relate to a history of a mild traumatic brain injury. It compares people with a past mild head injury to people without one to better understand what might be driving memory symptoms.
Dallas, TexasAges 55 years+ - NCT05201534Recruiting
Math and thinking skills training for school-age children
This trial studies interventions to improve math and cognitive (thinking) skills in elementary school children. It includes both children with math learning difficulties and typically developing children, using tests and MRI brain scans for those who can participate.
Palo Alto, CaliforniaAges 6–12 - NCT05079464Recruiting
Exercise plus brain stimulation to improve memory in early impairment
This trial tests whether a supervised exercise program, paired with brain stimulation, can improve thinking and memory in people with early “vascular” cognitive problems (not dementia). It may help your brain function before memory loss becomes more severe.
Toronto, OntarioAges 50 years+ - NCT05014399Recruiting
Study memory changes during chemotherapy for colorectal cancer
This study looks at cognitive (thinking and memory) changes in people with colorectal cancer who start certain chemotherapy drugs. It aims to understand how treatment affects the brain and may guide better monitoring or support during care.
Fort Wayne, IndianaAges 18 years+ - NCT03020381Recruiting
Study of walking patterns to predict dementia and falls
This study looks at how your walking (gait) might help predict future dementia and risk of falls. You may be asked to walk tests and have health information collected to see who is at higher risk.
London, OntarioAges 60–85 - NCT06705738Recruiting
Mediterranean diet and olive compound for mild memory loss
This study tests whether a Mediterranean diet combined with a natural compound found in extra virgin olive oil (oleocanthal) can help people with mild memory problems (mild cognitive impairment). It aims to see if this combination can slow down or improve memory decline.
Thessaloniki, ThessalonikiAges 60–85 - NCT06005038RecruitingPhase 1
Memory training study for older adults with mild cognitive issues
This study tests a computer-based memory training program to see if it can improve memory and thinking skills in older adults with mild cognitive impairment. It may help you if you have memory concerns but still live independently.
Palo Alto, CaliforniaAges 60 years+ - NCT07799584Recruiting
Brain stimulation with tai chi for mild memory problems
This study tests a new type of non-invasive brain stimulation combined with tai chi to see if it can improve memory and thinking in older adults with mild cognitive impairment (MCI), a stage between normal aging and dementia. It may help slow down memory decline and improve daily function.
Shanghai, Shanghai MunicipalityAges 60–80 - NCT05534607Recruiting
Community hula program for dementia risk in older Native Hawaiians
This study tests whether joining a community hula (dance) program can help people reduce future dementia risk. It focuses on older Native Hawaiian or Pacific Islander adults who already have mild memory concerns and certain health conditions like high blood pressure or diabetes.
Honolulu, HawaiiAges 50–75 - NCT07771036Recruiting
Brain stimulation for memory and balance in older adults with mild memory lapses
This study tests a new, non-invasive brain stimulation method (called temporal interference stimulation) to see if it can improve memory and balance while walking in older adults who have mild cognitive impairment. If you qualify, you might receive this stimulation and take part in memory and balance tests.
Shanghai, Shanghai MunicipalityAges 65 years+ - NCT07757542RecruitingPhase 2
Hydrogen gas for mild cognitive impairment
This trial tests whether breathing in a small amount of hydrogen gas is safe and might help people with mild cognitive impairment. It aims to see if this simple approach could support brain health.
Ostrava, Moravian-Silesian RegionAges 50–80 - NCT07651787Recruiting
Light Therapy for Early Memory Problems
This study tests whether light therapy can help improve thinking and memory in older adults with mild cognitive changes. Researchers will use light exposure to see if it supports brain health in people with signs of blood vessel disease in the brain.
Oklahoma City, OklahomaAges 55–95 - NCT07644156Enrolling by invitation
Exercise and Memory in Older Adults with Mild Cognitive Decline
This study tests whether regular physical exercise can improve memory and thinking skills in people 65 and older who have mild cognitive impairment. Researchers want to see if staying active helps protect brain function.
Shanghai, Shanghai MunicipalityAges 65–95 - NCT07570719Recruiting
Community screening for early Alzheimer's disease signs
This study screens people aged 60–80 for early signs of Alzheimer's disease in a community setting. Researchers will ask you questions and may perform brain imaging to understand who might benefit from early detection and treatment.
Shanghai, Shanghai MunicipalityAges 60–80 - NCT06734286Recruiting
Memory training study for mild cognitive impairment
This study tests a computer-based memory training program for people with mild cognitive impairment (MCI). It aims to see if practicing working memory exercises can help improve memory and thinking. You would use your own computer at home.
Phoenix, ArizonaAges 50 years+ - NCT07512739Recruiting
Sitting Tai Chi for Stroke Survivors With Cognitive Changes
This study tests whether a sitting tai chi program can help people who've had a stroke and are experiencing memory or thinking problems. You would learn tai chi movements while sitting, with your caregiver also participating in the program.
Kunming, YunnanAges 18 years+ - NCT07420426Recruiting
Smartphone therapy for memory and mood problems
This trial tests a therapy program delivered by text or voice message on your smartphone. It's designed to help people with mild memory problems manage mood or behavior changes.
Hong KongAges 50 years+ - NCT05893524Recruiting
Dementia and walking study using simple movement tests
This study looks at how memory problems and walking/mobility are connected. It may help researchers understand better ways to assess dementia risk and mobility changes early.
Falun, Dalarna CountyAges 37–94
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Common questions
- Are there clinical trials for cognitive impairment?
- Yes. Clin2 currently lists 571 recruiting cognitive impairment studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a cognitive impairment trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a cognitive impairment trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.