Clinical trials
Colon Cancer clinical trials
Below are recruiting colon cancer clinical trials, each written for real people, not researchers. We’re tracking 292 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05239546RecruitingPhase 2
Dostarlimab before colon surgery for mismatch-repair–deficient cancer
This study tests dostarlimab given before surgery for stage II or III colon cancer that has a specific DNA repair defect. It aims to shrink or control the cancer so that some people may be able to skip surgery if the results are good.
Iowa City, IowaAges 18 years+ - NCT05257135Recruiting
Study database and blood samples for colon cancer cachexia
This study collects clinical information and planned blood samples to better understand “cachexia,” which is a serious wasting condition that can happen with advanced cancer. It may help doctors find better ways to predict and manage symptoms in people with colon cancer who can’t have surgery.
MontpellierAges 18 years+ - NCT05296681RecruitingPhase 2
Probiotic trial to help irinotecan work better in metastatic colon cancer
This trial tests a “microbiome health” product (a probiotic-type supplement) to improve how well irinotecan chemotherapy works for people with metastatic colon cancer. It aims to support gut health so treatment can be delivered effectively.
Hamilton, New JerseyAges 18 years+ - NCT05426135Recruiting
AI tool to assess cancer risk and guide care
This study tests an artificial intelligence (AI) system that uses your health information and medical images to better judge cancer risk and support diagnosis and treatment decisions. It may help doctors make more consistent assessments by combining clinical records, imaging, and other lab-style data.
Wuhan, HubeiAges 18–75 - NCT05529615Recruiting
Blood DNA test guides chemotherapy after colon cancer surgery
This trial checks a blood test called circulating tumor DNA to help choose the best time and approach for chemotherapy after colon cancer surgery. It aims to reduce recurrence by identifying people who may benefit from treatment based on changes seen in the blood.
Beijing, Beijing MunicipalityAges 18–75 - NCT05709249RecruitingPhase 3
Chinese herbal medicine to help prevent colon cancer return
This Phase 3 study tests whether a Chinese herbal “decoction” (called XLJDOD) given after surgery and chemo can lower the chance that colon cancer comes back. It may help people with higher-risk colon cancer (Stage IIIB or IIIC) stay cancer-free longer.
NanjingAges 20–80 - NCT05713903Recruiting
Compare keyhole versus open surgery for right colon cancer
This trial compares two surgical approaches—keyhole surgery versus open surgery—for right colon cancer. It aims to see which approach works better and is safer for patients needing planned (elective) tumor removal.
LarissaAges 18–90 - NCT05870800RecruitingPhase 2
Study Immunotherapy and Chemotherapy Before Colon Surgery
This trial tests immunotherapy plus chemotherapy given before surgery for colon cancer that hasn’t spread. It aims to shrink or control the tumor and improve outcomes in people whose tumor has certain immune/biologic features.
Houston, TexasAges 18–80 - NCT06006390RecruitingPhase 1/Phase 2
CAR-T therapy for CEA-positive advanced solid tumors
This trial tests a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried other treatments.
Taiyuan, ShanxiAges 18 years+ - NCT06126406RecruitingPhase 1
CEA-targeting CAR-T cell therapy for advanced solid tumors
This trial tests a new immune cell therapy (CAR-T) designed to attack cancer cells that make a protein called CEA. It may be an option for people with advanced colorectal, esophageal, gastric, or pancreatic cancer who have already tried at least two standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT06239194RecruitingPhase 1/Phase 2
MdX2001 for advanced solid tumors
This trial tests a new drug, MDX2001, for people with advanced solid tumors that have spread. The study aims to find the best dose and see how well it works.
Denver, ColoradoAges 18 years+ - NCT06263088Recruiting
Equity in GI Cancer Care Study
This trial is looking for Black patients newly diagnosed with any stage of gastrointestinal cancer to help improve cancer care and make sure research includes everyone. By joining, you help doctors learn how to better support patients like you.
Cleveland, OhioAges 18 years+ - NCT06368141RecruitingPhase 2
Chemo plus immunotherapy before surgery for colon cancer
This trial tests whether giving chemotherapy followed by an immunotherapy drug (a checkpoint inhibitor) before surgery helps shrink locally advanced colon cancer. It is for people with a specific tumor type (MSS and RAS mutation) who have not had prior treatment.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT06447064Recruiting
Cancer loyalty card study for early detection
This study looks at whether shopping loyalty card data can help detect cancer earlier. If you have a Tesco Clubcard or Boots Advantage Card, you may be able to join by sharing your purchase history to help researchers find patterns linked to cancer.
LondonAges 18 years+ - NCT06485609Recruiting
Dye-guided surgery for right colon cancer
This trial tests whether adding a special dye (indocyanine green) during surgery to remove right-sided colon cancer helps the surgeon see and remove more lymph nodes. The goal is to improve cancer removal without adding extra risks.
GuangzhouAges 18–75 - NCT06530303RecruitingPhase 1/Phase 2
Personalized immune cell therapy for colorectal cancer
This trial tests a treatment made from your own immune cells (called TILs) that are taken from your tumor, grown in a lab, and given back to you along with immunotherapy. It is for people with advanced colon or rectum cancer who have run out of standard options.
Beijing, Beijing MunicipalityAges 16–90 - NCT06580574RecruitingPhase 2
Immunotherapy to save the stomach or colon from surgery
This trial tests whether using immune checkpoint inhibitors alone (like checkpoint blockade drugs) can help people with certain gastric or colon cancers avoid surgery. It's for patients whose tumors have a specific genetic feature called dMMR/MSI-H and haven't spread to other parts of the body.
Beijing, Beijing MunicipalityAges 18 years+ - NCT06609551RecruitingPhase 3
ctDNA-guided chemo choice for elderly colon cancer patients
This trial tests whether using a ctDNA blood test can help choose the best chemotherapy after colon cancer surgery for people aged 70–80. It aims to make treatment more personalized and reduce side effects.
Hangzhou, ZhejiangAges 70–80 - NCT06640166RecruitingPhase 2
Encorafenib + Cetuximab with FOLFIRI after progression
This trial tests adding a new chemotherapy regimen (FOLFIRI) to the combination of Encorafenib and Cetuximab for people with a specific type of advanced colorectal cancer that has started growing again after initial treatment with Encorafenib and Cetuximab. The goal is to see if the new combination can help control the cancer longer.
MilanAges 18 years+ - NCT06653478Recruiting
Smarter cancer risk assessment using all your medical info
This study is testing a new way to use medical images, records, and other information to better assess cancer risk and guide treatment. It may be a good fit if you have a suspicious spot in your lungs, stomach, or colon, or if you are healthy and want to help with early cancer detection research.
Wuhan, HubeiAges 18–75 - NCT06673329RecruitingPhase 1
Brodalumab for immune-related side effects from cancer treatment
This trial tests if brodalumab, an antibody that blocks a specific immune pathway (IL-17), can help control side effects caused by immunotherapy cancer treatment. It is for people with advanced solid organ cancers who have immune-related side effects that are suspected to involve IL-17.
New York, New YorkAges 18 years+ - NCT06682793RecruitingPhase 1/Phase 2
Study of A2B395 therapy for solid tumors with EGFR and HLA loss
This trial tests a new cell therapy called A2B395 for cancers that have EGFR, a protein on the cell surface, and have lost a specific marker called HLA-A*02. The therapy uses specially engineered immune cells to target and kill these cancer cells. This may help patients with colorectal, lung, head and neck, breast, kidney, or other solid tumors that are no longer responding to standard treatments.
Gilbert, ArizonaAges 18 years+ - NCT06686576RecruitingPhase 3
Study of QL1706 before surgery for MSI-H colon cancer
This trial tests a new immunotherapy medicine (QL1706) given before surgery to treat colon cancer that hasn't spread yet. It's designed for patients whose tumors have a specific gene feature (MSI-H/dMMR) and who haven't had any prior treatment for this cancer.
GuangzhouAges 18–75 - NCT07406087Recruiting
Navigation support for young adults after cancer
This study tests a navigation program to help cancer survivors ages 21-45 get the follow-up care they need. It may be a good fit if you were diagnosed with certain cancers as a teen or young adult.
Pasadena, CaliforniaAges 21–45
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Common questions
- Are there clinical trials for colon cancer?
- Yes. Clin2 currently lists 292 recruiting colon cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colon cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colon cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Beyond the search
We also like to point to nonprofits doing real good in this area. We aren’t affiliated with them — we just admire the work.
- Stand Up To CancerPeople facing cancer across many types, through the research that leads to better treatments.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.