Clinical trials
Colon Rectal Cancer clinical trials
Below are recruiting colon rectal cancer clinical trials, each written for real people, not researchers. We’re tracking 128 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07407465RecruitingPhase 2
Study of a new drug combo for advanced HER2-positive colorectal cancer
This trial tests a combination of three drugs (trastuzumab deruxtecan, capecitabine, and bevacizumab) as the first treatment for people with HER2-positive colorectal cancer that has spread or cannot be removed by surgery. The goal is to see if this combination can shrink tumors and help patients live longer.
LyonAges 18 years+ - NCT07427901Recruiting
Quality of life in colorectal cancer survivors
This study looks at how colorectal cancer and its treatment affect your daily life and well-being. It aims to help doctors better support patients like you during and after treatment.
LjubljanaAges 18 years+ - NCT07433673RecruitingPhase 2
Gemcitabine, cisplatin, nab-paclitaxel, and cemiplimab for locally advanced bile duct cancer
This trial tests a combination of four drugs to see if they shrink locally advanced bile duct or gallbladder cancer that cannot be removed surgically. It is for people who have not had prior treatment for this cancer.
New York, New YorkAges 18 years+ - NCT07450612Recruiting
Blood test and AI for early colorectal cancer detection
This study uses a simple blood test (liquid biopsy) and computer analysis to find early signs of colorectal cancer, precancerous growths, and Lynch syndrome. It aims to improve early detection and monitor for any remaining cancer after treatment.
Milan, LombardyAges 18 years+ - NCT07462143RecruitingPhase 2/Phase 3
New drug plus chemo for advanced colorectal cancer
This trial tests a new drug (RC148) combined with standard chemotherapy as a first treatment for colorectal cancer that has spread or cannot be removed. The goal is to see if this combination works better than chemotherapy alone.
Beijing, Beijing MunicipalityAges 18–75 - NCT07494201Recruiting
MIMICC study for people with colorectal cancer
This trial is studying patients with colorectal cancer who are scheduled for surgery. Researchers want to learn more about the cancer to improve future treatments.
Candiolo, Torino (TO)Ages 18–75 - NCT07595874RecruitingPhase 2
New Immunotherapy Drugs Before Surgery for Advanced Colorectal Cancer
This trial tests two immunotherapy drugs (botensilimab and balstilimab) given before surgery to treat advanced colorectal cancer that can be removed. The goal is to help the immune system fight cancer cells and improve outcomes after surgery.
Goodyear, ArizonaAges 18 years+ - NCT07669298Recruiting
Monitoring vs chemoradiation for early rectal cancer
This study compares two approaches after early-stage rectal cancer is removed: either careful monitoring or a follow-up treatment with chemotherapy and radiation. The goal is to see which strategy works better to keep the cancer from returning.
LimogesAges 18 years+ - NCT07213193Recruiting
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RomaAges 18 years+ - NCT07361107RecruitingPhase 1
Immune response study of histotripsy in colorectal cancer
This trial tests how your body's immune system reacts to a treatment called histotripsy for colorectal cancer that has spread to the liver. Histotripsy uses sound waves to break apart tumors, and the study aims to see if this can help your immune system fight the cancer better.
New Hyde Park, New YorkAges 18 years+ - NCT07534852Recruiting
Nutrition and exercise support for colon cancer surgery patients
This study tests whether nutrition support and exercise help patients with early-stage colon cancer recover better after surgery. Researchers will provide dietary guidance and a supervised exercise program tailored to your needs.
Málaga, MalagaAges 18–75 - NCT07469709Recruiting
Cancer risk study using genetics and monitoring
This study looks at genetic and other factors in people with certain cancers to better understand personal cancer risks and improve monitoring. It may help find ways to detect changes earlier.
Candiolo, TurinAges 18 years+ - NCT07610798RecruitingPhase 1/Phase 2
Testing INV-8989 for Advanced Cancers With KRAS G12D Mutation
This early-stage trial tests a new drug called INV-8989 designed to target a specific genetic mutation (KRAS G12D) found in some advanced solid cancers. The study will evaluate whether the drug is safe and if it can help shrink tumors in patients who haven't responded to standard treatments.
Guangzhou, GuangdongAges 18 years+ - NCT06338332Recruiting
Stent before surgery for right-sided colon blockage from cancer
This trial tests whether placing a stent first to relieve a blockage in the right side of the colon improves outcomes before surgery for colon cancer. It aims to help patients who come to the hospital with a blocked colon due to cancer.
Breda, North BrabantAges 18 years+ - NCT05051046Recruiting
Screening colonoscopy with hypnosis for colorectal cancer
This trial studies whether using hypnosis during a screening colonoscopy can help people better tolerate the procedure and complete it comfortably. It’s for adults who are scheduled for a routine screening colonoscopy and meet specific safety and communication requirements.
AngersAges 18–100 - NCT03280511RecruitingPhase 2
After surgery chemo sprayed into the abdomen for high-risk colon cancer
This Phase 2 study tests whether spraying chemotherapy into the abdomen (through a small procedure) after colon cancer surgery can lower the chance the cancer comes back. It is meant for people with high-risk tumor features but who have had surgery and have no proven relapse yet.
OdenseAges 18 years+ - NCT05534087RecruitingPhase 3
Blood test guided chemo after colon cancer surgery
This study tests whether giving additional (adjuvant) chemotherapy based on a special blood test—circulating tumor DNA (ctDNA)—can lower the risk of colon cancer coming back. It targets people with stage II–III colon cancer whose blood test is positive for minimal residual disease (MRD) after completing standard chemo.
BusanAges 19–75 - NCT07454720RecruitingPhase 2/Phase 3
Study of Adebrelimab with SHR-8068 and chemoradiation before surgery for rectal cancer
This trial tests whether adding two immunotherapy drugs (adebrelimab and SHR-8068) to standard chemoradiation before surgery can improve outcomes for adults with locally advanced rectal cancer that can be surgically removed.
Wuhan, HubeiAges 18–75 - NCT04089631RecruitingPhase 3
Blood test guides extra treatment after stage II colon cancer surgery
This study uses a blood test called ctDNA to decide whether you need extra (adjuvant) chemotherapy after stage II colon or certain stage II rectal cancer surgery. It may help avoid unnecessary treatment or better target people who still have signs of cancer after surgery.
Dresden, SaxonyAges 18 years+ - NCT02649647Recruiting
Surgery plan for rectal cancer after chemo-radiation
This trial looks at a specific type of rectal surgery after you’ve already finished chemo-radiation, aiming to remove the tumor while trying to preserve the anal sphincter (muscle control). It’s meant for people whose cancer can be safely operated on and who don’t have spread to distant organs.
Guangzhou, GuangdongAges 18–75 - NCT05365412Recruiting
Study of colon cancer in younger adults
This study looks at the clinic and lab features of colon cancer in people diagnosed at a young age. Your information from your diagnosis and treatment may help doctors understand how colon cancer differs by age.
Seongnam-si, Gyeonggi-doAges 18 years+ - NCT06560671Recruiting
App vs. paper for colonoscopy prep education
This study compares a new smartphone app to standard paper instructions for helping patients get their bowel ready for colonoscopy. It aims to see which method is easier to understand and leads to a better exam.
HsinchuAges 18 years+ - NCT06107920RecruitingPhase 3
Chemotherapy before surgery for blocked colon cancer
This trial tests whether giving chemotherapy before surgery helps people with colon cancer that caused a blockage and needed a temporary colostomy. It aims to improve outcomes compared to standard treatment.
AmiensAges 18 years+ - NCT07070622RecruitingPhase 3
Organ preservation for low rectal cancer after chemo
This trial tests whether chemotherapy alone can help avoid surgery for low rectal cancer. It is for people with tumors close to the anus that haven't spread far, and who haven't had prior cancer treatment.
Chengdu, SichuanAges 18–80
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Common questions
- Are there clinical trials for colon rectal cancer?
- Yes. Clin2 currently lists 128 recruiting colon rectal cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colon rectal cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colon rectal cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.