Clinical trials
Colorectal (Colon or Rectal) Cancer clinical trials
Below are recruiting colorectal (colon or rectal) cancer clinical trials, each written for real people, not researchers. We’re tracking 893 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07406087Recruiting
Navigation support for young adults after cancer
This study tests a navigation program to help cancer survivors ages 21-45 get the follow-up care they need. It may be a good fit if you were diagnosed with certain cancers as a teen or young adult.
Pasadena, CaliforniaAges 21–45 - NCT06028724Recruiting
Looking for cancer mutations using a blood test
This study uses a blood test (liquid biopsy) to find genetic changes in advanced solid tumors. It may help doctors choose the right treatment and monitor how well it works over time.
Aviano, PordononeAges 18 years+ - NCT04674267Recruiting
REACH study for older adults with GI cancer and support needs
This study looks at how to improve health and care support for people age 70 and older with gastrointestinal (GI) cancer. It may help by offering a structured way to address practical and emotional challenges that can affect aging and cancer care.
Boston, MassachusettsAges 70 years+ - NCT06822413Recruiting
Using light and AI to find cancer early
This trial uses a special light-based test and artificial intelligence to detect several types of cancer early. It aims to see if this method can accurately identify cancer or precancerous changes before any treatment starts.
Nanchang, JiangxiAges Any age - NCT06006390RecruitingPhase 1/Phase 2
CAR-T therapy for CEA-positive advanced solid tumors
This trial tests a new treatment called CAR-T cells that are designed to find and attack cancer cells carrying a protein called CEA. It is for people with advanced colorectal, esophageal, stomach, or pancreatic cancer who have already tried other treatments.
Taiyuan, ShanxiAges 18 years+ - NCT06126406RecruitingPhase 1
CEA-targeting CAR-T cell therapy for advanced solid tumors
This trial tests a new immune cell therapy (CAR-T) designed to attack cancer cells that make a protein called CEA. It may be an option for people with advanced colorectal, esophageal, gastric, or pancreatic cancer who have already tried at least two standard treatments.
Wuhu, AnhuiAges 18 years+ - NCT07723937Recruiting
GelPOINT-assisted removal of colon and rectal polyps
This study tests a new way to remove large or complex colon and rectal polyps using a special port system called GelPOINT Path. If you have polyps that are hard to remove with standard colonoscopy, this approach may help your doctor remove them safely.
Houston, TexasAges 18 years+ - NCT04920149RecruitingPhase 2
Mesalamine to help prevent colon cancer in Lynch syndrome
This trial tests whether mesalamine, a medicine used for bowel inflammation, can help prevent colorectal cancer in people with Lynch syndrome who do not currently have cancer. It may help by lowering the chance that new pre-cancer growths form over time.
AalborgAges 30 years+ - NCT05185245Recruiting
Liver transplant for colorectal cancer spread to the liver
This study looks at whether a liver transplant can help people whose colorectal cancer has spread to the liver but cannot be removed by surgery. It also checks whether certain cancer features, treatment history, and blood/health status make transplant safer or more effective.
BolognaAges 18–73 - NCT05186116Recruiting
Liver transplant for colon cancer that cannot be removed
This trial studies whether liver transplant (rather than removing the liver tumors) can help some people with colon or rectal cancer spread to the liver. It’s meant for people whose cancer has responded or stayed controlled on standard treatments and who have no cancer outside the liver.
Modena, MOAges 18–77 - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06314022Recruiting
Mobile app for better colonoscopy in cancer screening
This study tests a mobile app designed to help improve the quality of colonoscopies for people in a colorectal cancer screening program. If you have had a positive FIT test and are between 50 and 69, you may be able to join.
Valladolid, ValladolidAges 50–74 - NCT06698146Recruiting
Liver transplant for colorectal cancer that spread to the liver
This trial tests a special approach for colorectal cancer that has spread to the liver: first removing the liver tumor, then doing a partial liver transplant, and later removing more liver tissue. The goal is to see if this can help people who otherwise have limited options.
Chicago, IllinoisAges 18 years+ - NCT07033156Recruiting
Colorectal cancer detection using gene methylation test
This study is testing a new way to detect colorectal cancer early by looking for specific changes (gene methylation) in stool and blood samples. If you are 40 or older and have a colonoscopy scheduled, this non-invasive approach might help find cancer sooner.
Hangzhou, ZhejiangAges 40 years+ - NCT07046468Recruiting
Smart pill to check gut health in colon inflammation and cancer
This trial tests a smart pill that measures gut health in people with colon inflammation (ulcerative colitis) or colon cancer. It aims to see if the pill can help doctors better understand how the gut is working during treatment or before surgery.
Nijmegen, GelderlandAges 18 years+ - NCT07153458Recruiting
Finding new markers for colorectal cancer
This trial is looking for new, non-invasive markers to help detect and predict colorectal cancer. Researchers will study people with colorectal cancer, those with precancerous growths, and healthy people to find better ways to diagnose the disease.
Castellana GrotteAges 18 years+ - NCT07462650RecruitingPhase 1/Phase 2
CAR-NK cell therapy for advanced colorectal cancer
This trial tests a new treatment using modified natural killer cells (CAR-NK) that target two specific proteins found on your cancer cells. It is for people with advanced colorectal cancer who have tried standard treatments without success.
Shenzhen, GuangdongAges 18–75 - NCT03190941RecruitingPhase 1/Phase 2
T-cell therapy for HLA-A11:01 and KRAS G12V tumors
This trial tests a custom immune-cell treatment made from your blood that targets the KRAS G12V change in certain cancers. It is for people with advanced cancer who have already tried standard treatments, and it may help your immune system recognize and attack tumor cells.
Bethesda, MarylandAges 18–72 - NCT06711211Recruiting
Digestive cancer registry study
This study collects information from patients with different types of digestive cancers to better understand these diseases and improve future care. It does not test a new treatment, but helps doctors learn more about digestive cancers over time.
Madrid, MadridAges 18 years+ - NCT07179692RecruitingPhase 1
CEA-targeted CAR-T therapy for advanced solid tumors
This trial tests a type of immunotherapy called CAR-T, which is designed to recognize and attack cancer cells that have a protein called CEA on their surface. It's for people with advanced cancers like colorectal, esophageal, gastric, pancreatic, lung, or bile duct cancer who have tried at least two standard treatments.
Hefei, AnhuiAges 18 years+ - NCT05102110Recruiting
Check rectal mucus in people with throat or lung cancers
This study looks at a substance called rectal mucus during an exam to learn about changes in people with cancers of the throat/airways (aero-digestive tract). It’s a feasibility study, meaning it mainly tests whether this approach is safe and practical.
ExeterAges 18–99 - NCT06340646Recruiting
Washington University cancer gene study
This study collects genetic information from people with certain cancers to learn more about cancer risks and outcomes. It may help researchers understand how genes affect cancer in different groups.
St Louis, MissouriAges 18 years+ - NCT06926374Recruiting
Robotic surgery for gastrointestinal and urologic conditions
This trial tests a new robotic surgery system for common operations on the colon, rectum, prostate, kidney, bladder, stomach, esophagus, gallbladder, and hiatal hernia. It may offer a less invasive option for patients who need surgery for these conditions.
Hong KongAges 18–80 - NCT07268846Recruiting
Prebiotic supplement before colorectal cancer surgery
This trial tests if taking a postbiotic supplement before surgery for colorectal cancer can improve recovery. It may help patients with adenocarcinoma of the large intestine prepare for their operation.
São Paulo, São PauloAges 18 years+
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Common questions
- Are there clinical trials for colorectal (colon or rectal) cancer?
- Yes. Clin2 currently lists 893 recruiting colorectal (colon or rectal) cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal (colon or rectal) cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal (colon or rectal) cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.