Clinical trials
Colorectal Liver Metastasis clinical trials
Below are recruiting colorectal liver metastasis clinical trials, each written for real people, not researchers. We’re tracking 80 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07764497RecruitingPhase 2
Chemotherapy through liver artery for colorectal cancer that spread to liver
This trial tests giving chemotherapy directly into the liver artery for people whose colorectal cancer has spread only to the liver and cannot be surgically removed. The goal is to shrink the tumors and make the liver healthy enough for surgery.
Toronto, OntarioAges 18 years+ - NCT05057052RecruitingPhase 2
Freezing liver tumors with immunotherapy and a pill drug
This Phase 2 trial tests whether freezing (cryoablation) plus sintilimab (an immune system medicine) and regorafenib (a pill) can shrink colorectal cancer that has spread to the liver. It is for people whose cancer has come back or progressed after at least two prior chemotherapy treatments.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05248581Recruiting
Living donor liver transplant for unresectable colon cancer spread
This trial looks at using a living donor liver transplant for people whose colon or rectal cancer has spread to the liver in a way that can’t be removed with standard surgery. It may help if you might otherwise have limited options because your liver surgery would be too risky.
Rochester, New YorkAges 18 years+ - NCT04742621Recruiting
Liver transplant for colon cancer that spread only to the liver
This trial studies using a liver transplant to treat colon or rectal cancer that has spread to the liver but not anywhere else. It may help people with limited liver-only spread whose disease hasn’t worsened for a while.
New York, New YorkAges 18–65 - NCT04678583Recruiting
Surgery plan for RAS-mutant colon cancer liver metastases
This trial studies an approach to surgically removing liver metastases from colon (or rectal) cancer that has an RAS gene mutation (KRAS or NRAS). If you qualify, you would be evaluated for whether a “complete” (R0) liver operation is planned and technically possible, aiming to improve cancer control by how the liver is cut.
Mannheim, Baden-WurttembergAges 18 years+ - NCT06988852RecruitingPhase 2
Chemo infusion into liver for colorectal cancer spread
This trial tests a strong chemotherapy combination given directly into the liver's blood supply (called HAIC) for people whose colorectal cancer has spread only to the liver and cannot be removed with surgery yet. The goal is to shrink the liver tumors enough so they can be surgically removed.
Wuhan, HubeiAges 18–75 - NCT07027605Recruiting
Testing a computer tool for colorectal liver metastasis prognosis
This trial is testing a computer program that helps doctors predict outcomes for people with colorectal cancer that has spread to the liver. It is for patients who have had surgery to remove both the colon and liver tumors.
Beijing, Beijing MunicipalityAges 18 years+ - NCT07385521Recruiting
AI to predict cancer return after liver surgery
This trial uses artificial intelligence to predict whether colorectal cancer that spread to the liver will come back after surgery. It may help doctors better understand your risk and plan follow-up care.
MilanAges 18 years+ - NCT07392567Recruiting
AI predicts liver spread in colorectal cancer
This study tests whether an artificial intelligence (AI) model can predict if colon or rectal cancer will spread to the liver. You will have a CT scan before surgery, and the AI will analyze the scan to see if it can forecast future liver metastasis.
Wuhan, HubeiAges 18–75 - NCT02886104Recruiting
Surgery versus local ablation for certain liver metastases
This trial compares two ways to treat colorectal cancer that has spread to the liver: removing liver tumors with surgery versus destroying them in place with local ablation. It may help doctors learn which approach works best for people whose disease can be fully treated and who have enough healthy liver left.
Guangzhou, GuangdongAges 18–80 - NCT04491929Recruiting
Radiation treatment for colon cancer in the liver using tiny beads
This trial studies a targeted liver radiation procedure that uses tiny radioactive beads to treat colon cancer spread mostly in the liver. It may help people whose liver tumors cannot be removed or treated with other common local treatments, but it has several safety and “screening” checks.
Aarhus N, DanmarkAges 18 years+ - NCT07272928Recruiting
Comparing surgery order for liver spread from colon cancer
This trial looks at whether removing the colon tumor or the liver tumors first affects recovery in patients having both removed at the same time. It helps doctors decide the best surgical approach.
Alessandria, PiedmontAges 18 years+ - NCT07193862RecruitingEarly Phase 1
Testing a tiny device to find best treatments for liver tumors
This study tests a tiny device that is placed in your liver tumor during surgery. It checks how well different chemotherapy drugs work on your specific cancer, which may help your doctor choose the best treatment for you.
Lake Success, New YorkAges 18 years+ - NCT07399236Recruiting
AI prediction of liver spread in colorectal cancer
This study looks at whether an AI tool can predict if colorectal cancer will spread to the liver. The researchers will review past medical records of patients who had surgery to remove their cancer and had no signs of spread at that time.
Wuhan, HubeiAges 18–75 - NCT05185245Recruiting
Liver transplant for colorectal cancer spread to the liver
This study looks at whether a liver transplant can help people whose colorectal cancer has spread to the liver but cannot be removed by surgery. It also checks whether certain cancer features, treatment history, and blood/health status make transplant safer or more effective.
BolognaAges 18–73 - NCT05775146RecruitingPhase 2
Radiation to liver metastases after colon cancer treatment
This trial studies giving targeted high-dose radiation (SBRT) to liver metastases from colorectal cancer after initial treatment, with the goal of improving long-term control or cure. It may help people who have a limited number of liver spots that doctors think can be treated safely and effectively.
Edmonton, AlbertaAges 18 years+ - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT05861505RecruitingPhase 3
Treatment for new liver spread from colon cancer recurrence
This Phase 3 trial studies a treatment approach for people whose colorectal cancer has come back in the liver within 12 months and can be treated with local procedures. It aims to see whether the study treatment can improve outcomes compared with standard care for people with a limited number of liver tumors.
AmsterdamAges 18 years+ - NCT06130280RecruitingPhase 2
MRI-guided radiation for liver tumors from colorectal cancer
This trial tests a single, high-dose radiation treatment (SBRT) guided by MRI for people with colorectal cancer that has spread to the liver. The goal is to see if this precise, one-time treatment can effectively control liver tumors while protecting nearby organs.
Basking Ridge, New JerseyAges 18 years+ - NCT06185556RecruitingPhase 2/Phase 3
New treatments for liver tumors near blood vessels or bile ducts
This trial tests two procedures—irreversible electroporation and stereotactic body radiotherapy—for people whose colorectal cancer has spread to the liver (1–3 tumors near major blood vessels or bile ducts) and can't be surgically removed or treated with heat. The goal is to see if these approaches can safely destroy those hard-to-reach tumors.
Amsterdam, North HollandAges 18 years+ - NCT06200831Recruiting
Same surgery or two surgeries for colorectal cancer with liver spread
This trial compares having one surgery to remove both the colon tumor and liver tumors at the same time versus having two separate surgeries. It aims to find which approach is safer and works better for patients whose cancer has spread only to the liver.
OsloAges 18–80 - NCT06225843RecruitingPhase 2
Testing a new drug combo before liver surgery for colorectal cancer
This trial is for people with colorectal cancer that has spread to the liver. It tests whether adding a new drug (sotevtamab) to standard chemotherapy (FOLFOX) before surgery can help shrink tumors and improve outcomes.
Montreal, QuebecAges 18 years+ - NCT06287723Recruiting
Blood test for cancer DNA after liver surgery in colorectal cancer
This study uses a simple blood test (liquid biopsy) to look for tiny bits of cancer DNA after surgery for colorectal cancer that spread to the liver. It aims to see if this test can find cancer earlier than standard scans, which may help guide future treatment decisions.
MontpellierAges 18 years+ - NCT06630624RecruitingPhase 1/Phase 2
IP-001 with ablation for colorectal liver metastases
This trial tests whether adding the drug IP-001 to tumor ablation (microwave or irreversible electroporation) helps control colorectal cancer that has spread to the liver. The goal is to find the best dose and see how the immune system responds.
Amsterdam, North HollandAges 18 years+
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Common questions
- Are there clinical trials for colorectal liver metastasis?
- Yes. Clin2 currently lists 80 recruiting colorectal liver metastasis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal liver metastasis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal liver metastasis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.