Clinical trials
Colorectal clinical trials
Below are recruiting colorectal clinical trials, each written for real people, not researchers. We’re tracking 1,211 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05144152Recruiting
Testing M3 and FIT to predict polyp return in colon exams
This study checks how well two lab tests (M3 and FIT) can predict whether advanced colon polyps (adenomas) will come back. If you’ve had adenomas found on a prior colonoscopy, these results may help plan future surveillance.
Shatin, New TerritoriesAges 18 years+ - NCT05673148RecruitingPhase 3
Ablation treatment plus usual therapy for limited metastatic bowel cancer
This study tests whether adding “total ablation” (carefully destroying all visible small tumors using surgery, heat/cold treatment, and/or targeted radiation) to standard chemotherapy improves outcomes for people with limited spread of colorectal cancer. It may help by aiming to eliminate all known metastatic spots while you continue usual cancer treatment.
Kingman, ArizonaAges 18 years+ - NCT05919264RecruitingPhase 1/Phase 2
FOG-001 for advanced solid tumors with certain gene changes
This trial tests a new drug, FOG-001, alone or with other treatments, for people with advanced solid tumors that have specific changes in the WNT pathway genes. It aims to see if the drug can shrink tumors or slow their growth.
Phoenix, ArizonaAges 18 years+ - NCT06047379RecruitingPhase 1/Phase 2
Testing NEO212 for brain tumors and metastases
This trial tests a new drug called NEO212 for people with certain brain tumors (like astrocytoma or glioblastoma) or cancer that has spread to the brain from other parts of the body. The goal is to see if it is safe and if it can help shrink or control the tumors.
Beverly Hills, CaliforniaAges 18 years+ - NCT05705492RecruitingPhase 2
Olanzapine to help cancer-related weight and appetite loss
This Phase 2 trial tests whether olanzapine can help people with advanced cancer who are losing weight and not eating enough. It looks for improvements in appetite and weight while you receive your first-line palliative cancer treatment.
Portland, OregonAges 18 years+ - NCT03823144Recruiting
Imaging small live tumor details during surgery
This study uses a special camera to look at solid tumors from inside the body during an operation. It tests whether “live” tumor imaging (using a medicine called fluorescein) can be safely performed in people with certain solid cancers.
Jacksonville, FloridaAges 18 years+ - NCT04074538Recruiting
Colorectal cancer study to help researchers learn patterns
This study is collecting information from people with newly diagnosed colon or rectal cancer, to better understand the disease and support future research. It may help you and others by improving how colorectal cancer is studied and potentially treated over time.
Hangzhou, ZhejiangAges 18 years+ - NCT04307901Recruiting
Test a capsule that checks the colon when colonoscopy isn’t finished
This trial tests whether a swallowable camera capsule can safely check the colon and find possible tumor-related issues when a standard colonoscopy can’t be completed. It may help people who can’t or don’t want another colonoscopy right away.
SvendborgAges 18 years+ - NCT04489238Recruiting
Study of young and average-age colorectal cancer causes
This research collects health information (and for some groups, stool samples) to better understand why colorectal cancer happens in different age groups. If you fit the age and diagnosis criteria, your participation could help researchers find patterns that may improve future care.
Basking Ridge, New JerseyAges 18 years+ - NCT04592003Recruiting
French study of colorectal ESD performed by expert centers
This study follows people who are having a colon or rectum procedure called ESD in expert hospital centers in France. It mainly aims to collect information about outcomes and safety; joining depends on consent.
AmiensAges 18 years+ - NCT04815525Recruiting
Long-term bowel cancer risk after colonoscopy in Hong Kong
This study follows people in Hong Kong over time to learn how the future risk of advanced colon growth changes after they have a colonoscopy. It may help doctors better predict who needs closer follow-up in the years after a colonoscopy.
Shatin, New TerritoriesAges Any age - NCT05086614RecruitingPhase 3
Thymosin-alpha 1 after surgery for high-risk colon cancer
This trial looks at whether thymosin-alpha 1, an immune-support treatment, can help prevent colon cancer from coming back after surgery. It targets people with high-risk stage II or III colon cancer who have had the tumor removed.
Shanghai, Shanghai MunicipalityAges 18–75 - NCT05321134Recruiting
Testing single-port robot surgery for colorectal conditions
This study checks how well a newer single-opening (single-port) robot works for colorectal surgery. It may help surgeons perform operations with the robotic system in carefully selected colorectal conditions.
Sacramento, CaliforniaAges 18 years+ - NCT05495776Recruiting
Study checks how often Lynch syndrome happens in colon cancer
This registry study looks at how many people with colon cancer also have Lynch syndrome, an inherited condition that can affect cancer risk. If you enroll, your care team collects basic information from your diagnosis to better estimate how common it is.
MoscowAges 18 years+ - NCT05611034RecruitingPhase 1
Testing a lung treatment for colorectal cancer spread to lungs
This Phase 1 trial tests a targeted treatment delivered to the lungs for colorectal cancer that has spread to the lungs. It aims to see if the approach is safe and can reach lung tumors, especially when there are multiple lung lesions.
Toronto, OntarioAges 18–70 - NCT05630794RecruitingPhase 1
Test ONC201 to prevent colorectal polyp return in high-risk people
This Phase 1 study tests whether ONC201 is safe and may help prevent colorectal polyps (adenomas) from coming back. You’d also undergo planned colon/rectum camera exams to check for new or changing polyps.
Ann Arbor, MichiganAges 18 years+ - NCT05732623Recruiting
Study of early colorectal cancer risk factors in younger adults
This study looks at factors that may contribute to early-onset colorectal cancer (cancer in the colon or rectum diagnosed at a young age). It compares people with early-onset colorectal cancer to people without cancer to better understand possible causes and risks.
Denver, ColoradoAges 18–49 - NCT05771181RecruitingPhase 2
Test vitamin E plus two cancer drugs for metastatic colon cancer
This trial tests whether adding vitamin E to two cancer medicines (fruityquintinib and tislelizumab) can work better in people with metastatic colorectal cancer that is mismatch-repair stable (MSS). It may help if your cancer has grown despite standard treatment, and you can meet the study’s safety and blood/organ requirements.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05797077RecruitingPhase 3
After-surgery blood test–guided therapy for colon cancer liver spread
This Phase 3 trial tests whether an added “maintenance” treatment after liver surgery can help prevent colorectal cancer from coming back. It is only for people whose blood test (ctDNA) still shows signs of cancer after their operation.
Guangzhou, GuangdongAges 18–75 - NCT05803382RecruitingPhase 1
Adding a new drug to capecitabine for metastatic colorectal cancer
This Phase 1 study tests a new anti-cancer drug (ZEN003694) added to the usual chemotherapy capecitabine. It is for adults with colorectal cancer (and possibly other cancers) that has spread or cannot be removed and has continued despite prior standard treatment.
Irvine, CaliforniaAges 18 years+ - NCT05815082RecruitingPhase 3
ctDNA-guided chemo after liver surgery for colon cancer
This trial checks whether giving chemotherapy after surgery only for people whose blood test (ctDNA) shows no remaining cancer can help prevent the cancer from coming back. It is for people with colon cancer that has spread to the liver who had the tumor fully removed.
Guangzhou, GuangdongAges 18–75 - NCT05845450RecruitingPhase 2
Pre-surgery targeted drugs for selected colorectal cancer tumors
This trial tests targeted cancer drugs given before planned colon or rectal surgery. It may help by trying to shrink the tumor and treat specific tumor “targets” found in your stored pathology sample, depending on your tumor’s genetics and marker tests.
Milan, Lombardia/MIAges 18 years+ - NCT05898789Recruiting
Virtual rehab program for cancer survivors
This trial tests a virtual (online) rehabilitation and exercise program for people after breast, colorectal, head and neck, or certain blood cancers. It may help improve recovery and daily functioning by supporting safe activity and targeted rehab after treatment.
Toronto, OntarioAges 18 years+ - NCT05954078RecruitingPhase 3
ctDNA-guided chemotherapy after colon cancer surgery
This trial checks whether a special blood test (ctDNA methylation) can help decide the best chemotherapy after surgery for people at higher risk of colon cancer coming back. It may help spare some patients unnecessary treatment while aiming to improve outcomes for those likely to relapse.
Shanghai, Shanghai MunicipalityAges 18–80
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Common questions
- Are there clinical trials for colorectal?
- Yes. Clin2 currently lists 1,211 recruiting colorectal studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a colorectal trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a colorectal trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.