Colorectal clinical trials

Testing abemaciclib plus 5-FU for advanced colorectal cancer

This trial is testing whether adding a targeted drug called abemaciclib to the standard chemotherapy 5-FU can help people with a specific type of advanced colorectal cancer (MSS) that has stopped responding to other treatments. The goal is to see if this combination is safe and effective.

Lifestyle study for people at high risk of colorectal cancer

This study tests a lifestyle program for people who are at high risk for colorectal cancer but have not been diagnosed. The goal is to see if healthy changes can help lower your risk over one year.

Pilot study for a new colorectal cancer screening test

This study tests a new stool-based test for detecting colorectal cancer and advanced polyps. It aims to see how well it works compared to a colonoscopy. The results may lead to a simpler screening option.

Study of colon cancer that returns after surgery

This study looks at colon cancer that comes back in the same area after surgery. It may help doctors understand how to better treat this type of recurrence.

Improving follow-up care for colorectal cancer survivors

This study tests whether a navigator and online education can help colorectal cancer survivors get the recommended follow-up tests after surgery. If you've had surgery for stage I-III colorectal cancer in the last 3 months, this program may support you in staying on track with your surveillance.

Experimental drug for advanced colorectal cancer

This trial tests a new experimental drug (HNF4α srRNA) given through a vein for people with advanced colorectal cancer that has not responded to or cannot be treated with standard therapies. The goal is to see if this treatment can help shrink or slow the growth of the cancer.

AI-assisted colonoscopy for finding colorectal lesions

This trial tests whether artificial intelligence can help doctors better detect and classify growths in the colon during a colonoscopy. You may benefit from potentially more accurate results.

Personalized colon cancer vaccine trial for MSS stage 3 patients

This trial tests a custom-made vaccine designed from your tumor's genetic material. The vaccine is given alongside standard chemotherapy and an immunotherapy drug to try to prevent the cancer from coming back. It is for people with stage 3 colorectal cancer that has been fully removed by surgery and has certain high-risk features.

Nerve block for better pain relief after colon surgery

This study tests adding a special nerve block (peripheral autonomic block) to a standard abdominal wall block to see if it provides better pain relief after minimally invasive left-sided colon surgery. It may help patients experience less pain and use fewer pain medications.

Zanidatamab before surgery for HER2 positive colon or rectal cancer

This trial tests if the drug zanidatamab, given before surgery, can help treat colon or rectal cancer that has a specific marker called HER2. The goal is to see if this approach can shrink tumors and improve outcomes for people whose cancer has not spread to other parts of the body.

CAR-NK Cell Therapy for Advanced Colorectal Cancer

This trial tests a new type of immune cell therapy (CAR-NK cells) designed to fight advanced colorectal cancer that has spread or cannot be surgically removed. The therapy is customized to target specific protein markers on your cancer cells.

Genetic Risk Testing for Colorectal Cancer Screening

This study looks at how genetic risk information can help decide who needs colorectal cancer screening and when. Researchers want to see if testing for genetic risk factors improves screening decisions for people who haven't had a colonoscopy before.

Metabolic syndrome and recovery after colorectal cancer surgery

This trial studies how metabolic syndrome (a mix of high blood pressure, diabetes, and other factors) changes after colorectal cancer surgery. It aims to understand why some people's metabolic syndrome gets better after their tumor is removed, which could lead to better treatments.

Can a common antidepressant help your immune system fight colorectal cancer before surgery?

This trial is testing whether a common antidepressant called fluoxetine (Prozac) can help your immune system fight colorectal cancer before surgery. It's for people with early-stage colorectal cancer who have not yet had treatment.

Understanding New Cachexia Subtypes Through Observational Epidemiological Research

Home exercise for gut health in young colorectal cancer patients

This study tests whether a home-based exercise program can improve the health of your gut bacteria during chemotherapy for young-onset colorectal cancer. It aims to help you feel better and potentially improve how well your treatment works.

Mindfulness program for couples facing metastatic colorectal cancer

This study tests a mindfulness-based program for couples facing metastatic colorectal cancer. It aims to help reduce distress and improve coping for both patients and their partners.

New markers to better diagnose colorectal cancer referrals

This study looks for new markers in the blood or stool to help diagnose colorectal cancer earlier. It is for people who have been referred urgently because their doctor suspects lower bowel cancer.

Surgery plan for RAS-mutant colon cancer liver metastases

This trial studies an approach to surgically removing liver metastases from colon (or rectal) cancer that has an RAS gene mutation (KRAS or NRAS). If you qualify, you would be evaluated for whether a “complete” (R0) liver operation is planned and technically possible, aiming to improve cancer control by how the liver is cut.

Study of biomarkers in MSI-high colorectal cancer patients on immunotherapy

This trial is studying people with a specific type of advanced colorectal cancer (MSI-high/dMMR) who are starting immunotherapy with pembrolizumab. The goal is to find out which markers in the tumor might predict whether the treatment works well.

Study of 4 drugs for advanced colorectal cancer

This trial tests a combination of four drugs for people with advanced colorectal cancer who have already tried at least two other treatments. The goal is to see if this new mix can help shrink tumors or slow the cancer's growth.

Testing a new camera tool to measure colon polyps

This trial tests a computer-assisted measurement system during a colonoscopy to see if it can more accurately measure polyps. You might consider this if you are scheduled for a routine colonoscopy for screening or monitoring.

Immunotherapy trial for advanced colorectal cancer

This trial tests a new immunotherapy drug (STC-1010) for people with colorectal cancer that cannot be removed by surgery or has spread. It aims to see if the drug can shrink tumors or slow the disease.

Study of a new drug plus standard chemo for advanced colorectal cancer

This trial tests if adding the experimental drug pelareorep to standard chemotherapy (FOLFIRI) and bevacizumab can help people with a specific type of advanced colorectal cancer that has a RAS mutation and is not caused by high microsatellite instability. You may be able to join if you've already tried one type of chemotherapy and it stopped working or you couldn't tolerate it.