Clinical trials
Constipation clinical trials
Below are recruiting constipation clinical trials, each written for real people, not researchers. We’re tracking 98 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07545772RecruitingPhase 2
Testing Brenipatide for Constipation-Focused IBS
This trial tests a new medicine called brenipatide to see if it can help people with IBS-C (irritable bowel syndrome with constipation). The study focuses on whether the drug reduces belly pain and improves bowel movements in people whose main symptom is hard or infrequent stools.
Mesa, ArizonaAges 18–75 - NCT06810167RecruitingPhase 3
Testing tenapanor for cystic fibrosis-related constipation
This study tests whether the drug tenapanor can help people with cystic fibrosis who have constipation. It may be an option for those whose current treatments are not working well.
Boston, MassachusettsAges 18–75 - NCT06911749Recruiting
Using MSOT and MRI to measure bowel transit in children
This trial tests whether two imaging techniques, MSOT and MRI, can safely and non-invasively measure how long it takes for food to move through the bowels in children with chronic constipation or other bowel emptying problems. It may help doctors better understand and treat these conditions.
Erlangen, BavariaAges 1 year+ - NCT07065942Recruiting
Lactulose for gut health in diabetes with constipation
This study tests if a common stool softener called lactulose can improve gut health and metabolism in people with type 2 diabetes and long-term constipation. It aims to see if changing gut bacteria can help both digestion and blood sugar control.
BeijingAges 18–70 - NCT07094035Recruiting
Green tea and probiotics for constipation-predominant IBS
This study tests whether a supplement containing green tea extract and probiotics can improve bowel function in people with irritable bowel syndrome (IBS) that mainly causes constipation. If you have chronic constipation and abdominal pain, this could help.
NaplesAges 18–70 - NCT07213856Recruiting
Dietary help for constipation in Parkinson's disease
This study tests whether a special diet can help improve constipation symptoms in people with early-stage Parkinson's disease. It aims to see if changing what you eat can make bowel movements more regular and comfortable.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT07231796Recruiting
Study of naldemedine for opioid-induced constipation in cancer patients
This trial tests whether naldemedine, a medication for constipation, can help cancer patients who have constipation caused by opioids. It looks at how well it works and how patients feel.
AmsterdamAges 18 years+ - NCT07372326Recruiting
Electronic moxibustion for constipation after stroke
This trial tests if a type of heat therapy called electronic moxibustion, timed according to traditional Chinese medicine principles, can help relieve constipation in people who have had a stroke.
Jinhua, ZhejiangAges 30–80 - NCT07654959Recruiting
Test anxiety and bowel health in physiotherapy students
This study looks at how test anxiety affects bowel health and constipation in students. It may help understand the link between stress and digestive problems.
Ankara, AnkaraAges Any age - NCT05821309RecruitingPhase 4
Testing how a new enema routine changes gut bacteria
This study looks at how placing an antegrade (forward-flow) continence enema and starting a bowel flush routine may change your gut microbiome (your gut bacteria). It is meant for children who have long-lasting constipation that required a special surgical drainage channel.
Carmel, IndianaAges 2–18 - NCT05796388Recruiting
Virtual reality and linaclotide for IBS with constipation
This study tests whether virtual reality (VR) plus linaclotide can improve symptoms and quality of life in adults with IBS-C (IBS with constipation). You may be asked to use VR and take a study medicine, while doctors check that your IBS diagnosis fits strict criteria.
Jacksonville, FloridaAges 18–70 - NCT03842007Recruiting
Study of constipation symptoms and how bowel function works
This study looks at how normal bowel movements work, and what goes wrong in people with long-term constipation. It may help researchers better understand constipation causes, which can guide future treatments.
Rochester, MinnesotaAges 18–80 - NCT07225803Recruiting
Managing pelvic floor muscle problems that cause constipation
This study tests a treatment for a specific type of constipation caused by pelvic floor muscles not working together properly (dyssynergic defecation). It aims to help people who strain or feel blocked when trying to have a bowel movement.
Rochester, MinnesotaAges 18–80 - NCT06494917Recruiting
Manual therapy and pelvic floor exercises for constipation
This trial tests whether manual therapy (hands-on muscle work) and pelvic floor exercises can help people with constipation. It's a chance to try a non-medication approach for better bowel function.
ŞırnakAges 18–55 - NCT06825260RecruitingPhase 4
PEG3350 vs Senna after urogynecologic surgery
This study compares two common laxatives to see which works better for preventing constipation after surgery for pelvic organ prolapse or stress urinary incontinence. It will help find the best way to keep you comfortable during recovery.
Syracuse, New YorkAges 18 years+ - NCT07388264Recruiting
Probiotic for bloating and gut health
This study tests a probiotic (a good bacteria) called Weizmannia coagulans to see if it helps reduce bloating and improves gut health. Researchers will check how your digestion changes by looking at your stool and gut bacteria.
Saint Charles, MissouriAges 18–50 - NCT05905926Enrolling by invitationPhase 3
Tenapanor safety study for teens with constipation-predominant IBS
This trial checks the safety of tenapanor in children and teens (ages 6 to under 18) with IBS-C. It is only for people who finished a previous related study and agreed to continue follow-up.
Foley, AlabamaAges 6–18 - NCT06847919Recruiting
Probiotic yogurt for chronic constipation
This study tests whether eating a special probiotic yogurt can help relieve chronic constipation. It may be a simple, natural addition to your diet with minimal side effects.
Suzhou, JiangsuAges 18–65 - NCT06335797Recruiting
Improving bowel habits after pelvic surgery
This study looks at ways to improve bowel habits after vaginal surgery for pelvic organ prolapse. It aims to find better routines to help you recover comfortably.
Winston-Salem, North CarolinaAges 18 years+ - NCT07135362Recruiting
Probiotic for improving constipation in adults
This trial tests a probiotic supplement to see if it helps improve bowel function in people with constipation. If you have functional constipation (not caused by another illness), this study may be a good fit.
TaipeiAges 18–65 - NCT07732894Recruiting
Exercise and Guided Imagery for Bowel Symptoms After Cancer Surgery
This study tests if combining gentle aerobic exercise with guided imagery (a relaxation technique using your imagination) can help improve bowel control and reduce symptoms after rectal cancer surgery.
IstanbulAges 18–65 - NCT05588323RecruitingPhase 1/Phase 2
Testing naldemedine for constipation caused by opioid pain meds
This study tests whether naldemedine is safe and how the body processes it in children who take opioid medicines and are dealing with constipation or are at risk for it. It may help some children by reducing constipation side effects from opioid pain treatment.
TiranaAges 2–18 - NCT06801184Recruiting
Gut bacteria study for constipation-predominant IBS with methane
This study looks at the gut bacteria in people with irritable bowel syndrome (IBS) who have constipation and produce high levels of methane gas. It aims to understand how methane relates to symptoms and may guide future treatments.
LyonAges 18 years+ - NCT04014413Recruiting
Fecal transplant for gut and immune-related conditions
This trial studies whether fecal microbiota transplantation (FMT)—a medical procedure using stool from a screened donor to restore gut bacteria—can improve safety and outcomes for people with certain bowel, immune, and metabolic conditions. It may help if your symptoms are thought to be related to an unhealthy gut microbiome, though eligibility is broad and depends on specific safety factors.
Hong Kong, ShatinAges Any age
Hear when a new Constipation trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Common questions
- Are there clinical trials for constipation?
- Yes. Clin2 currently lists 98 recruiting constipation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a constipation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a constipation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.