Clinical trials · Massachusetts
Coronary artery disease clinical trials in Massachusetts
We’re tracking 31 recruiting coronary artery disease studies with a site in Massachusetts — including Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT03217006Recruiting
Compare one vs multiple heart artery grafts for bypass
This study looks at whether using one artery graft or multiple artery grafts during heart bypass surgery works better for people with specific coronary artery disease. You may be randomized to one approach, and the trial team will follow outcomes after surgery.
Springfield, MassachusettsAges 18–70 - NCT06374498Enrolling by invitation
Looking inside heart arteries to improve stent placement
This study tests a new imaging technique to help doctors see inside your heart arteries during a stent procedure. It may help guide treatment and improve outcomes for people with heart disease.
Boston, MassachusettsAges 18 years+ - NCT07286578Recruiting
Using heart CT scans to guide treatment for blocked arteries
This trial is testing whether a special heart CT scan (coronary CT angiography) can help doctors better understand and treat calcium buildup in your heart arteries. If you have a type of heart disease that might need a stent or other procedure, this study could help decide the best approach.
Boston, MassachusettsAges 18–85 - NCT07232069RecruitingPhase 3
Early heart disease trial for women and men with mild plaque buildup
This trial tests whether two medicines, a statin and colchicine, can slow or stop early heart artery plaque from growing in people who have mild plaque but no heart disease symptoms yet. It uses special CT scans to measure plaque over 2 years.
Boston, MassachusettsAges 30–60 - NCT06959524Recruiting
AGENT balloon for new heart artery blockages
This trial tests a drug-coated balloon (AGENT DCB) versus standard angioplasty/stenting for new blockages in heart arteries. It aims to see if the coated balloon works better and is safe for people who haven't had prior stents in that spot.
Boston, MassachusettsAges 18 years+ - NCT06779630Recruiting
Study of a 48mm drug-coated stent for long coronary artery blockages
This trial tests a longer-than-usual drug-coated stent (Orsiro Mission) for treating long blockages in heart arteries. It aims to see if the stent is safe and effective for people with coronary artery disease.
Boston, MassachusettsAges 18 years+ - NCT04124120Recruiting
Single vs multiple bypass grafts for women heart surgery
This study compares outcomes of using one bypass graft versus multiple bypass grafts during coronary artery bypass surgery in women. It aims to see which approach leads to better recovery and heart outcomes for eligible patients.
Worcester, MassachusettsAges 18 years+ - NCT04634240Recruiting
Staged heart bypass plus TAVR versus TAVR alone
This study compares doing a staged coronary bypass (revascularization) along with a valve procedure (TAVR) versus doing TAVR and medical treatment alone. It aims to see which approach better helps people with both aortic valve narrowing and coronary artery disease.
Boston, MassachusettsAges Any age - NCT05908331Recruiting
Balloon treatment test for narrowed stents in heart arteries
This trial tests whether a special drug-coated balloon (“MagicTouch”) can treat re-narrowing inside a previously placed stent. It may help patients whose stent has become blocked again, by improving blood flow and reducing repeat narrowing.
Boston, MassachusettsAges 18–110 - NCT06027788Recruiting
Embolic protection during heart valve surgery
This trial tests a device that may help protect your brain from small particles during heart valve surgery. It is for people 60 and older having certain types of valve replacement or repair.
Boston, MassachusettsAges 60 years+ - NCT06235112Recruiting
AI Screening for Heart Calcium from Chest CT Scans
This research study uses an artificial intelligence program to screen old chest CT scans for calcium buildup in the heart arteries. If you are between 40 and 75 and have had a chest CT in the last 3 years, this may help identify if you are at risk for heart disease so you can take steps to prevent it.
Boston, MassachusettsAges 40–75 - NCT06399692RecruitingPhase 3
Heart treatment study for women with blocked arteries
This trial is comparing two common heart procedures—bypass surgery (CABG) and stents (PCI)—to see which works better for women with blockages in multiple heart arteries. It aims to find the best treatment for women, who are often underrepresented in heart research.
Boston, MassachusettsAges 18 years+ - NCT06399705RecruitingPhase 3
Comparing bypass surgery vs stenting for minority heart patients
This trial compares two common heart procedures—bypass surgery and stenting—for people with multiple blocked arteries. It focuses on minority groups to find out which treatment works best for them. You will be asked to fill out quality-of-life questionnaires for up to 10 years.
Boston, MassachusettsAges 18 years+ - NCT07087431Recruiting
Genetic risk score for heart disease and health habits
This study looks at whether sharing a genetic risk score for heart disease can help people make heart-healthy changes. If you're not on cholesterol medication, you may be able to join.
Boston, MassachusettsAges 30–75 - NCT04451044Enrolling by invitation
Guided heart stent planning using an inside pressure sensor
This study tests whether using a tiny pressure sensor in heart arteries during a procedure can better guide where to place a stent. It may help doctors choose the safest and most effective stent plan by more accurately measuring artery narrowing.
Boston, MassachusettsAges 18 years+ - NCT05491668Recruiting
Testing heart artery narrowing before planned stent procedure
This study checks how severely blocked a coronary artery is using measurements taken during a planned heart catheterization, to help guide whether and how to do a stent (PCI). It may help doctors choose the best treatment plan for people with about 70% or more narrowing.
Boston, MassachusettsAges 18 years+ - NCT02061436Recruiting
Chronic total occlusion procedure registry
This study collects data from patients who are having a procedure to open a completely blocked coronary artery. It may help improve future treatments for this condition.
Boston, MassachusettsAges Any age - NCT06662500Recruiting
Shockwave balloon for hard heart blockages trial
This trial tests a new balloon catheter that uses sound waves to break up hard calcium blockages in heart arteries. It may be an option for people with stable chest pain or who have recovered from a recent heart attack, and who have a single, tough blockage.
Boston, MassachusettsAges 18 years+ - NCT01524276Recruiting
Registry to track outcomes of Medtronic medical devices
This is a follow-up registry that collects information from people who have (or will receive) an eligible Medtronic device. It helps the company and doctors better understand how the device works in real-world use.
Boston, MassachusettsAges Any age - NCT05946629Recruiting
Drug-coated stent trial for narrowed heart arteries
This trial studies a drug-coated balloon (plus standard heart medicines) to treat a specific type of blockage in the heart arteries in people who need an intervention. It may help keep the artery open and prevent the narrowing from coming back, depending on how well you match the detailed heart and medication requirements.
Boston, MassachusettsAges 18 years+ - NCT06445608Recruiting
Study of a heart pump for high-risk angioplasty
This trial tests a temporary heart pump (called the KARDION Cory P4) used during a high-risk angioplasty (stenting) procedure. The pump helps keep blood flowing in patients whose heart is weak or who have complex blockages, aiming to make the procedure safer.
Boston, MassachusettsAges 18–90 - NCT07559903Recruiting
Drug-coated balloon heart artery treatment registry
This study tracks outcomes in adults who receive a special balloon catheter (coated with medication) to open blocked heart arteries. Researchers collect data to understand how well this treatment works and any side effects that occur.
Boston, MassachusettsAges 18 years+ - NCT05916950Recruiting
Study of a new treatment for blocked leg arteries
This trial studies a device-based treatment approach for people with blocked (narrowed or fully blocked) arteries in the thigh or behind the knee that reduce blood flow to the leg. It may help improve blood flow and walking ability, but you must meet specific artery and imaging requirements.
Leominster, MassachusettsAges 18 years+ - NCT07062471Recruiting
Shockwave balloon treatment for hardened carotid arteries before stenting
This study tests a special balloon that uses sound waves to break up calcium buildup in the carotid artery (the main artery in your neck) before placing a stent. It's for people who are at high risk for traditional surgery and have heavy calcium deposits in their artery.
Boston, MassachusettsAges 18 years+
Coronary artery disease trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting coronary artery disease studies listed above.
- Massachusetts General Hospital · 14 studies
- Brigham and Women's Hospital · 7 studies
- Beth Israel Deaconess Medical Center · 6 studies
- Tufts Medical Center · 3 studies
- Baystate Health · 2 studies
- Baystate Medical Center
- Southcoast Health System
- University of Massachusetts Chan Medical School
What taking part in a coronary artery disease study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Coronary artery disease trials in other states
Common questions
- Are there coronary artery disease clinical trials in Massachusetts?
- Yes. We're currently tracking 31 recruiting coronary artery disease studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a coronary artery disease study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a coronary artery disease trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New coronary artery disease studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.