Clinical trials
Couples clinical trials
Below are recruiting couples clinical trials, each written for real people, not researchers. We’re tracking 97 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07447284Recruiting
Improving sleep for African American couples with OSA
This study tests whether a couple-based approach helps African American patients with moderate to severe sleep apnea stick with CPAP therapy better. It is designed for patients and their bed partners who want to improve sleep health together.
Cleveland, OhioAges 30 years+ - NCT06649929Enrolling by invitationPhase 2
Better sleep for Latino couples and brain health
This study tests a program to help Latino couples improve sleep and CPAP use, which may lower Alzheimer's risk. You and your partner will join telehealth sessions together.
Tuscon, ArizonaAges 35 years+ - NCT07604740Enrolling by invitation
Does couple therapy help strengthen relationships before baby arrives?
This study tests whether couple counseling helps parents-to-be and blended families in the Helsinki area work through relationship challenges. The researchers want to see if therapy helps couples feel more connected and secure before their first child is born.
HelsinkiAges 18 years+ - NCT07214012Recruiting
Couples learning about birth control during pregnancy
This study tests a program where you and your partner learn about birth control options together during pregnancy. It aims to help you make a plan that fits your family's needs.
Knoxville, TennesseeAges 18 years+ - NCT06047691Recruiting
Couples therapy for PTSD in military couples
This study tests whether intensive couples therapy helps military couples dealing with PTSD, compared to a relationship education class. If you are a service member or veteran with PTSD and your partner is willing to join, this trial might offer a way to improve your relationship and PTSD symptoms together.
San Antonio, TexasAges 18 years+ - NCT06307977Recruiting
Couples counseling to reduce drug use and HIV risk
This study tests a couple-focused counseling approach to help male couples reduce drug use and lower the risk of HIV. You and your partner would join sessions together to talk about safer choices and support each other.
Detroit, MichiganAges 18–55 - NCT06690788Recruiting
Couples program to prevent type 2 diabetes (PreventT2 Together)
This research study looks at whether a lifestyle program designed for couples can help prevent type 2 diabetes. Both partners take part together, and the program is based on the National Diabetes Prevention Program.
Salt Lake City, UtahAges 18 years+ - NCT06892613Recruiting
Couples therapy for depression and anxiety in married couples
This trial compares two types of couples therapy (EFCT and BCT) to see which works better for depression and anxiety. If you and your spouse are feeling stressed, anxious, or low, this study may help you strengthen your relationship and improve your mood.
Istanbul, IstanbulAges 18–65 - NCT07759921Recruiting
Mindfulness program for couples facing metastatic colorectal cancer
This study tests a mindfulness-based program for couples facing metastatic colorectal cancer. It aims to help reduce distress and improve coping for both patients and their partners.
Aurora, ColoradoAges 18–85 - NCT07753473Recruiting
Brain stimulation for young adults with depressive symptoms
This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve how the brain and heart work together in people aged 18 to 30 who have mild depressive symptoms. The goal is to understand if this treatment could help with mood regulation.
Xi'an, ShaanxiAges 18–30 - NCT07123623Recruiting
childbirth classes for couples to reduce fear and boost support
This study tests whether having expectant parents take childbirth classes together helps pregnant women feel more supported by their partner, less afraid of giving birth, and more confident in their ability to deliver. It is designed for women who have already had a vaginal birth before and are at least 20 weeks pregnant.
Istanbul, IstanbulAges 18–50 - NCT07125118Recruiting
Self-help for couples with relationship distress
This trial tests a self-help program for couples who have a child at home and are experiencing relationship distress or conflict. The goal is to see if online tools can help improve your relationship without needing to see a therapist right away.
Aarhus, Region MidtAges 18 years+ - NCT05875376Recruiting
Couple program for adults with autism
This study tests a new program designed to help couples where one partner has Autism Spectrum Disorder or high autistic traits. It focuses on improving communication and relationship skills through a series of sessions.
TaipeiAges 20–60 - NCT05786157Recruiting
Couples alcohol and safety support for drinking and relationship harm
This study tests a patient-focused approach to help couples where alcohol misuse and relationship physical harm may be happening. You may be asked to take part in sessions focused on safety, coping, and relationship communication, and some components may include controlled alcohol exposure.
Charleston, South CarolinaAges 21 years+ - NCT07100951Recruiting
Comparing two couples therapies for relationship distress
This study compares two types of couples therapy to see which is better at reducing relationship distress. If you and your partner are feeling unhappy or struggling, and either of you also has symptoms of depression or anxiety, this trial may offer free professional help.
IstanbulAges 24–65 - NCT07159633Recruiting
Strengthening relationships for couples recovering from substance use
This trial tests an online program to help couples improve their relationship while one or both partners are in treatment or recovery from substance misuse. It's designed for couples who want to stay together and have internet access.
Marietta, GeorgiaAges 18 years+ - NCT05833074Enrolling by invitation
Testing HIV risk again each year for male couples
This study looks at whether repeating HIV testing once a year for male couples at higher risk helps results stay on track over time. It includes couples who previously took part in an earlier study and are willing to keep participating.
Ann Arbor, MichiganAges 17–65 - NCT07613307RecruitingPhase 3
Study of a new pill for type 2 diabetes during Ramadan fasting
This study tests an oral medication called orforglipron to see if it safely helps people with type 2 diabetes manage their blood sugar while they fast during Ramadan. You may be a good fit if you are planning to fast and your diabetes is not too severe.
AgraAges 18–65 - NCT06895590Recruiting
Testing a new water-based blood pressure cuff
This trial tests a new, very accurate blood pressure cuff that uses water to get a better reading. It is for adults who already need a standard blood pressure cuff and an arterial line as part of their hospital care.
Boston, MassachusettsAges 18 years+ - NCT07759609Recruiting
Intrauterine insemination after pregnancy loss
This study tests whether intrauterine insemination (IUI), a simple procedure where sperm is placed directly into the uterus, improves the chance of a successful pregnancy for couples who have had at least one unexplained miscarriage. It aims to help couples who are trying again within a year of their loss.
Beijing, Beijing MunicipalityAges 20–37 - NCT06296849RecruitingPhase 2
Quit smoking together as a couple with financial incentives
This trial tests if offering money rewards can help couples who both smoke to quit together. You and your partner would both join the program and get support to stop smoking.
Athens, GeorgiaAges 18 years+ - NCT06907654Recruiting
Couples' affect and relationships study
This study looks at how couples' moods and relationships interact over time. You and your partner will use a smartphone app and respond to daily text surveys for 3 weeks.
Madison, WisconsinAges 18 years+ - NCT06943365Recruiting
Role of Anti-TREK-1 Antibodies in Sudden Cardiac Arrest Without Blockage
This study looks for a specific type of antibody (called anti-TREK-1) in the blood of people who have had a sudden cardiac arrest without a clear cause. It aims to understand if these antibodies play a role in the condition, which might help with future diagnosis or treatment.
Vancouver, British ColumbiaAges 18 years+ - NCT06659315Recruiting
Preventing HIV transmission from mom to baby for depressed mothers in Malawi
This study tests a program to help pregnant women with HIV who also have depression, and their partners, reduce the risk of passing HIV to their babies. The program includes support for mental health and HIV care.
ZombaAges 18 years+
Hear when a new Couples trial opens
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Common questions
- Are there clinical trials for couples?
- Yes. Clin2 currently lists 97 recruiting couples studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a couples trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a couples trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.