Clinical trials
Crohn’s disease clinical trials
A type of inflammatory bowel disease causing inflammation of the digestive tract. We’re tracking 334 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05321745Recruiting
Fecal transplant for children with Crohn’s disease
This trial tests whether transferring stool microbes (called fecal microbiota transplantation, or FMT) can improve Crohn’s disease in children who have not gotten better with usual treatments. If you qualify, the study will check symptoms and colon imaging/score changes over the study follow-up.
Wuhan, HubeiAges 2–16 - NCT06494826Recruiting
Study of gut bacteria and proteins in new Crohn's disease patients
This study looks at proteins from your body and gut bacteria to understand Crohn's disease better. You may join if you are about to have your first colonoscopy for suspected Crohn's and have not had any treatment yet.
AfulaAges 18 years+ - NCT06505304Recruiting
AI endoscopy to predict Crohn's return after surgery
This trial uses artificial intelligence during colonoscopy to predict if Crohn's disease will come back after surgery. It aims to improve early detection and guide treatment decisions.
LeuvenAges 18–75 - NCT06520397RecruitingPhase 4
Combination therapy vs. higher dose ustekinumab for Crohn's
This trial tests whether a combination of two drugs (upadacitinib and ustekinumab) works better than a higher dose of ustekinumab alone for people with active Crohn's disease that hasn't responded well to previous treatments.
Guangzhou, GuangdongAges 18–70 - NCT06629194Recruiting
Comparing tests to tell intestinal TB from Crohn's disease
This study looks at different scoring systems to help doctors tell the difference between intestinal tuberculosis (a bacterial infection) and Crohn's disease (a chronic inflammatory condition). If you have ulcers in your ileum or colon and are undergoing a colonoscopy, you may be able to help doctors improve how they diagnose these conditions.
Bangkok Noi, BangkokAges 18 years+ - NCT06631586RecruitingPhase 2
Microbiota transplant for Crohn's disease
This study tests if a standardized fecal transplant is safe and helpful for adults with moderately to severely active Crohn's disease who are already on maintenance therapy. The goal is to see if this treatment can reduce inflammation in the digestive tract.
Minneapolis, MinnesotaAges 18–89 - NCT06721962RecruitingPhase 1/Phase 2
Testing an experimental treatment for moderate to severe Crohn's disease
This trial is testing a new investigational treatment called TRX103 for adults with moderate to severe Crohn's disease that has not responded to at least two other advanced therapies. The study aims to see if this treatment can reduce inflammation and improve symptoms.
Scottsdale, ArizonaAges 18–65 - NCT06833450Recruiting
Intestinal ultrasound for monitoring Crohn's disease
This study uses an intestinal ultrasound (a safe, painless scan) to check how well Crohn's disease is controlled. It may help doctors see inflammation without more invasive tests.
AmiensAges 18 years+ - NCT06858553Recruiting
AI-assisted MRI for intestinal scarring in Crohn's disease
This trial uses AI to improve MRI scans for detecting intestinal fibrosis (scarring) in people with Crohn's disease who are scheduled for surgery. It aims to help doctors better identify and treat scarring.
Guangzhou, GuangdongAges 18–75 - NCT06976853RecruitingPhase 2
Testing a new drug for Crohn’s disease beyond inflammation
This study tests a medicine called tirzepatide to see if it can help people with active Crohn’s disease who have not responded to multiple prior treatments. It focuses on how the drug might work beyond just reducing inflammation.
Beverly Hills, CaliforniaAges 18–80 - NCT07152431Recruiting
Using a special scan to find scar tissue in Crohn's disease
This study uses a special imaging tracer (FAPI) to find scar tissue in the small intestine of people with Crohn's disease. The goal is to see if this scan can help doctors better understand which parts of the intestine are scarred, which may guide treatment decisions.
EdinburghAges 18–90 - NCT07292012RecruitingPhase 4
Mirikizumab to heal intestinal damage in Crohn's disease
This trial tests if mirikizumab can reduce deep inflammation in the intestine walls in people with active Crohn's disease. It may help heal damage that shows up on an MRI scan.
BrestAges 18–75 - NCT07363044Recruiting
Biologic selection guided by epigenetic markers in Crohn's disease
This trial compares two different ways to choose your Crohn's treatment: one based on a special test of your cells (epigenetic markers) and the other based on standard care. It aims to see which approach works better for people with moderate to severe Crohn's disease.
AntwerpAges 18 years+ - NCT07364734Recruiting
Study of hard-to-treat Crohn's disease
This study looks at people with Crohn's disease that is hard to treat. It aims to understand the disease better and see how well current treatments work.
Guangzhou, GuangdongAges 18–65 - NCT03219359RecruitingPhase 2
Stem cell transplant using your own cells for Crohn’s flare
This Phase 2 study tests whether a transplant using your own stem cells can calm active Crohn’s disease that hasn’t improved with standard medicines. It may help some people with ongoing inflammation and symptoms after multiple Crohn’s treatments.
New York, New YorkAges 18 years+ - NCT07629245RecruitingPhase 1/Phase 2
Cell therapy for Crohn's disease fistulas after prior treatment
This trial tests whether injecting your own fat-derived cells combined with a skin graft can heal anal fistulas (abnormal passages near the anus) that didn't respond to or came back after a previous cell therapy study. You must have already participated in the ADICROHN-2 study.
MarseilleAges 18 years+ - NCT06165289Enrolling by invitation
Balloon dilation with PRP for Crohn's colon narrowing
This trial tests whether adding a platelet-rich plasma (PRP) injection to the standard balloon dilation procedure can help treat a narrowed section of the colon caused by Crohn's disease. It may offer a way to avoid or delay surgery for some patients.
Guangzhou, GuangdongAges 18 years+ - NCT06523647Recruiting
Effectiveness of Ustekinumab for Crohn's Disease
This study looks at how well Ustekinumab (Stelara) works for Crohn's disease in people who started the medication in 2024. Researchers want to understand its real-world benefits and safety.
AktobeAges 18 years+ - NCT07444060Recruiting
Guselkumab vs Ustekinumab for stricturing Crohn's disease
This study compares two medicines, Guselkumab and Ustekinumab, for people with Crohn's disease that causes narrowing (strictures) in the bowel. It aims to find which works better to improve symptoms and avoid the need for more procedures.
Hangzhou, ZhejiangAges 18–80 - NCT06045754RecruitingPhase 4
Study of vedolizumab with other drugs for Crohn's disease
This trial tests whether combining vedolizumab with adalimumab or ustekinumab helps people with moderate to severe Crohn's disease who haven't responded to other treatments. It aims to find better ways to manage symptoms and improve quality of life.
Dothan, AlabamaAges 18–70 - NCT06324838Recruiting
Surgery study for Crohn's disease in the ileocecal area
This trial compares two surgical techniques for removing the affected part of the intestine in people with Crohn's disease. It aims to see if removing more tissue around the blood vessels leads to better outcomes.
OdenseAges 18 years+ - NCT06902987RecruitingPhase 1
Upatinib for anal fistulas in Crohn's disease
This trial tests whether upatinib can help heal active anal fistulas in people with moderate to severe Crohn's disease. If you have an anal fistula that is causing pain or drainage, this study may offer a new treatment option.
Guangzhou, GuangdongAges 18–70 - NCT05599347RecruitingPhase 2
Azithromycin before anti-TNF treatment for Crohn’s disease
This Phase 2 trial tests whether taking azithromycin (an antibiotic) before starting infliximab or adalimumab can reduce the chance your body rejects the anti‑TNF medicine. It may help some people get better and keep responding to treatment.
Haifa, Haifa DistrictAges 18 years+ - NCT05113095Recruiting
Survey of Darvadstrocel in Crohn’s with fistulas
This is a survey study in people with Crohn’s disease who have complex perianal fistulas and have already received Darvadstrocel. It aims to understand how patients are doing after treatment and gather real-world feedback.
Tokyo, TokyoAges 20 years+
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Common questions
- Are there clinical trials for crohn’s disease?
- Yes. Clin2 currently lists 334 recruiting crohn’s disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a crohn’s disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a crohn’s disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.