Clinical trials
Dental Pain clinical trials
Below are recruiting dental pain clinical trials, each written for real people, not researchers. We’re tracking 39 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07253025Recruiting
Comparing Two Root Canal Fillings for Pain Relief
This study compares two types of root canal filling materials—a resin-based sealer and a bioceramic sealer—to see which one causes less pain after the procedure. If you have a tooth with a painful, infected nerve (irreversible pulpitis), this trial may help determine which filler offers better comfort.
Peshawar, Khyber Pakhtoon Khawa(KPK)aAges 17–70 - NCT06757075RecruitingPhase 4
Managing pain after children's dental surgery
This study tests different ways to manage pain in young children after dental surgery done under general anesthesia. It aims to find the best method to keep children comfortable and reduce discomfort.
Brighton, MassachusettsAges 4–6 - NCT07101068Recruiting
Comparing two ways to give dental numbing for kids
This study tests a new dental injector against a traditional syringe to see which one causes less pain and anxiety for children getting numbed for their first cavity treatment.
Cairo, Cairo GovernorateAges 6–8 - NCT07400471RecruitingEarly Phase 1
Pain relief before root canal: a medicine combination
This trial tests whether a combination of pain medicines given before a root canal can lower pain afterward. It is for people who have moderate to severe tooth pain and are healthy enough for standard treatment.
Chittagong, ChattogramAges 18 years+ - NCT00804154RecruitingPhase 1
Capsaicin-like drug for severe cancer pain
This Phase 1 trial tests a new drug related to capsaicin (resiniferatoxin) to reduce severe nerve pain from advanced cancer. It is given through a small catheter near the spinal fluid space and is meant for people whose pain medicines and other options have not worked well enough.
Bethesda, MarylandAges 18–99 - NCT06836882Recruiting
Testing cavity disinfectants for deep tooth decay pain
This study tests two cavity disinfectants to see which one better reduces pain and improves healing after removing deep decay from back teeth. It is for adults with deep cavities in their lower molars that are still alive (not needing a root canal).
HaryānaAges 18 years+ - NCT06819033RecruitingPhase 4
Light therapy for canker sores in children
This study tests whether a special light treatment (photobiomodulation) can help reduce pain from canker sores (aphthous ulcers) in children. It may be a good option for kids who get painful mouth sores during dental visits.
Houston, TexasAges 5–17 - NCT04880707RecruitingPhase 2
Pain medication options for lower wisdom tooth removal
This study compares pain-medication approaches during and after removing at least one lower impacted wisdom tooth (a tooth that’s stuck). It may help find a safer or more effective way to control dental pain after surgery.
Newark, New JerseyAges 18 years+ - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25 - NCT07041905Recruiting
Comparing two ways to treat deep cavities in back teeth
This study compares two ways of removing deep tooth decay to see which keeps the tooth nerve healthy and causes less pain afterward. It's for people who have two deep cavities on opposite sides of their mouth and want to help find the best treatment.
AdanaAges 15–55 - NCT07330518Recruiting
Comparing two numbing techniques for lower tooth removal
This study compares two ways to numb the lower jaw for removing a back tooth: one blocks a small nerve near the cheek, the other blocks the main nerve trunk. The goal is to see which method works better and causes less discomfort.
Islamabad, Islamabad, PakistanAges 20–60 - NCT07247929Recruiting
Pain and swelling after third molar surgery
This trial compares two surgical methods for removing partially impacted wisdom teeth to see which causes less pain and swelling afterwards.
Islamabad, IslamabadAges 18–45 - NCT07296926Recruiting
Numbing injection comparison for wisdom tooth removal
This study compares two numbing methods for removing a lower wisdom tooth. One is an injection near the tooth and the other is a nerve block. It aims to see which works better and may be more comfortable.
IslamabadAges 18–45 - NCT07198919Enrolling by invitationPhase 1/Phase 2
Pain relief during root canal for infected tooth: gel vs. antibiotic paste
This trial compares two medicines placed inside a tooth after root canal cleaning to see which reduces pain better between appointments. If you have an infected single-root tooth and are between 16-45 years old, you may be able to join.
Karachi, SindhAges 16–45 - NCT07166679Recruiting
Larger root canal tip for healing infection in back molars
This study tests whether making the tip of the root canal slightly larger during a single root canal treatment helps the infection heal better and reduces pain afterward. It is for people with a dead lower back molar that has an infection around the root tip.
RohtakAges 18–65
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Common questions
- Are there clinical trials for dental pain?
- Yes. Clin2 currently lists 39 recruiting dental pain studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a dental pain trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a dental pain trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.