Clinical trials
Dental clinical trials
Below are recruiting dental clinical trials, each written for real people, not researchers. We’re tracking 490 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06528574Recruiting
Pain after root canal cleaning methods
This trial compares two methods of cleaning a tooth's root canal to see which causes less pain after the procedure. It is for people with a specific type of tooth nerve pain (acute pulpitis) in a lower back molar.
Cleveland, OhioAges 18–50 - NCT06538233RecruitingPhase 2
Pain after buffered vs. non-buffered numbing medicine
This trial compares two versions of a numbing medicine (articaine) to see which causes less pain during dental work on upper front teeth.
Cleveland, OhioAges 18–60 - NCT06552936Recruiting
Laser therapy for faster healing after tooth extraction
This study tests whether using a special laser after a lower-jaw tooth extraction can help the socket heal faster and grow new bone. It may benefit people who plan to get a dental implant later.
Lahore, Punjab ProvinceAges 21 years+ - NCT06555029Recruiting
Oral health help for older adults on Medicaid
This trial is testing an oral health program offered during routine primary care visits for older adults (55+) on Medicaid. It aims to see if adding dental care support to regular check-ups can improve health.
Cleveland, OhioAges 55 years+ - NCT06564987RecruitingPhase 1
Risk of nerve damage from numbing shots for dental work
This study looks at whether a common numbing shot for dental procedures can cause nerve damage. It may help dentists choose safer ways to numb your teeth.
Akron, OhioAges 18–55 - NCT06569329Recruiting
Extra cleaning for infected root canals
This study tests if extra cleaning steps after a standard root canal can remove more bacteria from an infected tooth. It is for adults with a dead nerve and an infection at the root tip in a single-rooted premolar that has never been treated before.
Iowa City, IowaAges 18–95 - NCT06571812Recruiting
Study of the TSX dental implant system (Xpresso)
This trial tests a new dental implant system (called TSX Xpresso) for replacing a single missing tooth, either right after pulling the tooth or after the gum has healed. It may be a good option if you need a dental implant and want to see how this system works.
Columbus, OhioAges 18 years+ - NCT06576063Recruiting
Light therapy for better oral hygiene in older adults
This study tests a special light therapy (called antibacterial photodynamic therapy) used with a device called Lumoral to improve oral hygiene in older adults. It may help reduce bacteria and plaque in people who can brush their teeth and follow the study routine.
Loviisa, UusimaaAges 65 years+ - NCT06597669Recruiting
Comparing two treatments for cavities in baby molars
This clinical trial compares two methods for fixing cavities in baby molars: a traditional metal crown and a simpler technique that seals the crown over the cavity without removing much tooth. It aims to find which method works better in children.
Huế, Thừa Thiên Huế ProvinceAges 3–9 - NCT06602375Recruiting
Physical therapy and exercise for jaw pain
This study tests if adding manual physical therapy and exercise to standard dental care helps active-duty service members with jaw pain (temporomandibular disorders). It aims to see if this combination works better than dental care alone.
Fort Sam Houston, TexasAges 18–55 - NCT06608563Recruiting
Dental sealant study for kids and molars
This study tests a special adhesive to help sealants stick better and prevent cavities on back teeth in children aged 6 to 12.
Dublin, DublinAges 6–12 - NCT06619574Recruiting
Testing the dental compass for jaw joint positioning
This study tests a new tool called a Dental Compass that helps dentists place your jaw joint back in the right position more accurately and quickly. It may help relieve TMJ pain and improve jaw function.
Gainesville, TexasAges 18–90 - NCT06627790RecruitingPhase 3
Herbal mouthwash for tooth sensitivity
This study tests a herbal mouthwash containing potassium nitrate against a potassium oxalate mouthwash to see which better reduces tooth sensitivity. If you have sensitive teeth, you may be eligible to try a new rinse that could help reduce pain.
Pune, MaharashtraAges 18–60 - NCT06641011Recruiting
Sealing molars with enamel spots: rinsing vs blotting
This study tests whether rinsing off or blotting dry a special silver fluoride liquid before placing a tooth sealant helps the sealant last longer on molars affected by a common condition called molar-incisor hypomineralization. The goal is to find the best way to protect these teeth from cavities.
AnkaraAges 6–14 - NCT06643663Recruiting
Gum surgery for teeth with gum disease and failed root canal
This study tests a gum surgery technique (guided tissue regeneration) to help heal teeth that have both gum disease and a failed root canal. It looks at how well the tooth heals and how it affects your daily life.
HaryānaAges 16 years+ - NCT06653868Recruiting
Sticky bone grafts for front tooth implants
This trial tests two different types of sticky bone graft materials placed around a dental implant right after a tooth is removed. It aims to see which type helps the bone heal better around the implant in the front of your mouth.
CairoAges 20–50 - NCT06685640Recruiting
Comparing metal and ceramic crowns for back baby teeth
This trial tests whether stainless steel or zirconia crowns work better for fixing cavities in children's back baby teeth after nerve treatment. It can help parents choose the best option for their child.
Aydin, AydınAges 4–5 - NCT06699199RecruitingPhase 4
Testing silver diamine fluoride on mouth bacteria in kids
This study tests if a liquid medicine (silver diamine fluoride) painted on baby teeth cavities can change the bacteria in a child's mouth. It is for healthy children ages 4–10 with an open cavity.
Jeddah, Mecca RegionAges 4–12 - NCT07688278Recruiting
Diabetes screening for people with advanced gum disease
This trial tests whether checking blood sugar (HbA1c) at the dentist can find undiagnosed diabetes. It is for adults with advanced periodontitis (severe gum disease) who have not already been told they have diabetes.
SkåneAges 18 years+ - NCT06714929Recruiting
School water study for students in grades K-5
This study looks at how a new water program in schools might affect student health and hydration. It includes watching what kids drink at lunch, checking teeth and body weight for older students, and asking 4th and 5th graders and staff about their drinks.
Henrico, VirginiaAges 4 years+ - NCT06723678Recruiting
Bone changes around implants with All-on-Four technique
This trial tests a special technique called 'All-on-Four' for people who need full-arch dental implants. It looks at how the bone around the implants changes over time. If you are in good general health and have a healthy jawbone, this study might help you understand if this approach works well for you.
Cairo, Nasr CityAges 50–65 - NCT06727110Recruiting
New liquid treatment for tooth cavities
This study tests a new method to treat cavities that reach the middle layer of a tooth. It may help repair the tooth with a liquid that hardens into a filling. If you have a back tooth with a cavity that hasn't been filled yet, you might be eligible to join.
San Francisco, CaliforniaAges 18–64 - NCT06730360Recruiting
Light therapy for pulp treatment in young children's molars
This study tests whether a special light treatment (photobiomodulation) can help heal the nerve inside a child's first permanent molar when the tooth has deep decay and a painful nerve condition (irreversible pulpitis). The goal is to see if this approach can save the tooth and avoid more invasive treatments.
Al Mansurah, Dakahlia GovernorateAges 6–9 - NCT06757075RecruitingPhase 4
Managing pain after children's dental surgery
This study tests different ways to manage pain in young children after dental surgery done under general anesthesia. It aims to find the best method to keep children comfortable and reduce discomfort.
Brighton, MassachusettsAges 4–6
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Common questions
- Are there clinical trials for dental?
- Yes. Clin2 currently lists 490 recruiting dental studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a dental trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a dental trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.