Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,504 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07239011RecruitingPhase 1/Phase 2
Dapagliflozin for depression study
This trial tests whether dapagliflozin, a diabetes medication, can help treat major depression. It is for adults who have been depressed for at least 2 months and score high on a depression scale.
Damietta, New DamiettaAges 18–60 - NCT07198438Enrolling by invitation
Deep vs standard brain stimulation for depression
This trial compares two types of brain stimulation (deep vs standard theta burst stimulation) to see which works better for people with depression who haven't gotten enough help from antidepressant medication. It aims to find a more effective treatment option.
Douliu, Yunlin CountyAges 18–70 - NCT07163013Recruiting
Digital therapy for teens with depression
This trial tests a digital therapy (a phone- or computer-based program) that teaches you skills to manage depression. It is designed for Chinese-speaking teens who have moderate to severe depression and are not currently receiving other treatment.
ChongqingAges 12–18 - NCT07118072Recruiting
Online therapy for childhood trauma and depression symptoms
This study will test if a special online therapy program, called i-STAIR, can help people who had a tough childhood and are now dealing with some depression symptoms. It focuses on building skills to manage emotions and relationships, all from the comfort of your home.
SingaporeAges 21–65 - NCT06565936Recruiting
PET/MRI brain scans for understanding depression
This trial uses two special brain scans (DPA-714 and FDG PET/MRI) to look at inflammation and brain activity in people with first-episode or recurrent depression, and in healthy volunteers. It aims to find brain differences that could lead to better treatments.
Dalian, LiaoningAges 35–85 - NCT07064551Recruiting
Combining medical and community support for depression
This study tests a new way of combining medical care with community support for middle-aged and older adults who have depression and are waiting for mental health services. The goal is to see if this team approach can help improve mood and well-being while you wait.
Hong KongAges 45 years+ - NCT06580249Recruiting
Brain stimulation for pleasure loss in teen depression
This trial tests if repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation, can help teenagers with depression who have lost interest or pleasure in things they used to enjoy.
Xi'an, ShaanxiAges 10–19 - NCT03276793Recruiting
Brain connectivity study in people with depression
This study looks at brain “connectivity” (how different brain areas talk to each other) in people with depression. You may be able to join if you are already getting once-daily TMS to a specific brain area at Brigham and Women’s or Massachusetts General, and you can safely complete MRI scans.
Boston, MassachusettsAges 18 years+ - NCT06951542Enrolling by invitation
Reducing HIV and mental health stigma in Malawi
This study tests a program to reduce stigma for people living with HIV who also have symptoms of depression. It aims to improve mental health and HIV outcomes.
MulanjeAges 18 years+ - NCT06751784RecruitingPhase 2
Fampridine's effect on memory in mild to moderate depression
This study tests whether the drug fampridine can improve working memory (like short-term memory and focus) in people with mild to moderate depression. The trial is run by the University of Basel and involves multiple visits.
Basel, Canton of Basel-CityAges 18–55 - NCT05678907Recruiting
Test whether a depression questionnaire predicts relapse after discharge
This study checks whether your answers on a depression questionnaire can predict the chance of depression coming back after you leave the hospital. If it works, it may help doctors spot relapse risk earlier and plan follow-up care.
La Roche-BlancheAges 18 years+ - NCT06709027Enrolling by invitation
Mobile health program for depression in older adults
This study is testing a smartphone-based health program designed for older adults with depression. The program aims to help you manage your mood and track changes in thinking and memory using a mobile app.
Fuzhou, FujianAges 60 years+ - NCT06910267Recruiting
Depression treatment study for older adults in APS
This study tests if a proven depression treatment can help older adults who are involved with Adult Protective Services due to neglect or self-neglect. If you are feeling depressed and have an open APS case, you may qualify.
Houston, TexasAges 65 years+ - NCT06905223Recruiting
Synbiotics for adults with mild to moderate depression
This pilot study tests whether taking a combination of probiotics and prebiotics (synbiotics) can improve mood in adults with depressive symptoms. It may be an option if you have mild to moderate depression and are looking for a supplement-based approach.
Hong KongAges 18 years+ - NCT05736471Recruiting
Online survey study of thinking and emotions
This study tests how people’s thinking patterns and feelings change during online tasks and surveys. It may help researchers understand how cognition (thinking) and mood (feelings) are connected.
Minneapolis, MinnesotaAges 18 years+ - NCT06775548Enrolling by invitation
Exercise and vitamins for depression relief
This study tests if combining aerobic and resistance exercises with vitamins D and E can reduce stress and inflammation in people with mild to moderate depression. It may help improve mood and overall well-being.
Karachi, SindhAges 25–35 - NCT05923801Recruiting
Optimizing ECT treatment for difficult depression
This trial studies better ways to deliver ECT (electroconvulsive therapy) for people with difficult-to-treat depression, including some people with bipolar depression. You may be offered an ECT strategy that’s tailored to your situation, with the goal of improving outcomes and reducing problems.
KortenbergAges 18 years+ - NCT06876129RecruitingPhase 1
Adding D-serine to TMS for depression
This trial tests whether adding a medication called D-serine to a brain stimulation treatment (TMS) helps improve depression. It’s for adults with major depression who are already getting TMS therapy.
Belmont, MassachusettsAges 18–80 - NCT07269964Recruiting
At-home brain stimulation for depression maintenance
This trial tests if a gentle, at-home brain stimulation treatment (tDCS) can help prevent depression from returning after successful initial treatment with esketamine, rTMS, or ECT. It is for people who are stable but want to stay well.
München, BavariaAges 18 years+ - NCT07287878Recruiting
Brain stimulation to improve social reward in depression
This trial tests a new type of brain stimulation called temporal interference stimulation to see if it can improve how people with depression experience social rewards. You may be eligible if you have depression with certain features like increased appetite, weight gain, or feeling very sensitive to rejection, and you are between 16 and 60 years old.
Shanghai, ChinaAges 16–65 - NCT06776887Recruiting
Virtual reality exercises for burn recovery on legs
This trial tests whether virtual reality exercises can help people with leg burns improve balance and reduce depression and anxiety. It is for people who had a large thermal burn on their lower body at least 3 months ago.
GizaAges 35–55 - NCT06721559Recruiting
Home program for older adults with depression and mobility issues
This study tests a home-based program called Empower@Home for older adults who have depression and trouble moving around. It aims to see if the program helps improve mood and daily life—without adding extra outside therapy.
Ann Arbor, MichiganAges 50 years+ - NCT05814640RecruitingPhase 1/Phase 2
STAR-AD: Testing stepwise treatment for teen depression
This trial tests a step-by-step approach to treating moderate-to-severe depression in teens. It may help find a treatment path that improves mood while keeping care safe, including for some teens who have suicidal thoughts but do not need inpatient care.
Chongqing, ProvinceAges 13–18 - NCT06656416RecruitingPhase 2
ALTO-100 for bipolar depression
This trial tests an investigational drug called ALTO-100 in people with bipolar I or II who are currently experiencing depression. It looks at whether this new medicine can help improve depression symptoms when taken alongside your usual mood stabilizer or antipsychotic medication.
Chandler, ArizonaAges 18–70
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,504 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.