Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,419 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07492537Recruiting
Helping with low mood after your first heart attack
This trial is for people who have just had their first heart attack and may be feeling some low mood or sadness. It aims to understand and help with these feelings early on, before they become a bigger problem.
Roma, ItaliaAges 18 years+ - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07490379Recruiting
Home vs. Hospital Brain Stimulation for Depression
This trial compares doing transcranial direct current stimulation (tDCS) at home versus in the hospital to see if it works as well for depression. tDCS uses a mild electrical current on the scalp to help improve mood.
AngletAges 18 years+ - NCT07484217RecruitingPhase 3
Testing solriamfetol for depression with daytime sleepiness
This study tests if the drug solriamfetol can help people with major depression who also feel very tired during the day. It aims to improve both mood and daytime sleepiness.
Tucson, ArizonaAges 18–65 - NCT07485387Recruiting
Korean cognitive aging study using smartphone app
This study looks at how thinking and memory change as people get older. It uses a smartphone app to track these changes over time in healthy older adults living in South Korea.
Seoul, Select One...Ages 60 years+ - NCT07485036Recruiting
Study on mood and alcohol use in new mothers
This study looks at how new mothers feel emotionally, including mood, alcohol use, and symptoms of depression. By participating, you can help researchers understand the challenges mothers face in the first year after childbirth.
Chicago, IllinoisAges 18 years+ - NCT06777563Recruiting
Mood app and check-ins to prevent postpartum depression
This study tests whether using a smartphone program (mHealth) along with emotional support (EMA) can help prevent postpartum depression in pregnant women who are feeling distressed. It is for women in Hong Kong who are at 20–28 weeks of pregnancy and have mild to moderate mood symptoms.
Hong Kong, PokfulamAges 18 years+ - NCT07476469Recruiting
Nerve stimulation for anhedonia and anxiety
This study tests whether a gentle nerve stimulation device (tVNS) placed on your ear can help reduce symptoms of anhedonia (loss of pleasure) and anxiety. You will also have brain scans (MRI) to see how the treatment affects your brain.
BonnAges 18–40 - NCT06787300Recruiting
Stories that empower mothers and prevent postpartum depression
This study tests a program to support mothers during pregnancy and after childbirth, focusing on preventing or easing postpartum depression. You will join online sessions designed to help you feel more confident and connected.
IzmirAges 18 years+ - NCT03272698RecruitingPhase 4
Ketamine plus ECT versus higher-dose ketamine with rescue
This study compares two ways of using ketamine with ECT (electroconvulsive therapy) in people with treatment-resistant depression. It aims to find whether a higher-dose ketamine approach, with extra rescue measures, works better or more safely.
Saskatoon, SaskatchewanAges 18 years+ - NCT06223880RecruitingPhase 4
AXS-05 vs Bupropion to prevent depression relapse
This study tests whether a new drug called AXS-05 can prevent depression from coming back, compared to an older drug called bupropion. If you have major depression and are at risk of relapse, this trial may help you stay well.
Bellflower, CaliforniaAges 18–65 - NCT06439043Recruiting
Testing adapted EMDR for depression online vs in person
This study looks at a talking therapy called EMDR adapted for depression. It compares doing the sessions online versus face-to-face to see which works better.
KohatAges 20–50 - NCT07464886RecruitingPhase 3
NAC and mindfulness therapy for depression in youth
This study tests whether a supplement called N-acetylcysteine (NAC) combined with a type of therapy called Mindfulness-Based Cognitive Therapy (MBCT) can help improve depression in teenagers and young adults. It looks at how these treatments affect brain chemicals and may reduce symptoms.
Cincinnati, OhioAges 15–24 - NCT07462013Recruiting
Lifestyle changes to prevent memory loss with depression
This study tests if healthy lifestyle changes can protect memory and thinking skills in people with depression who have no or mild memory problems.
Taichung, TaichungAges 50–80 - NCT07462637Recruiting
Light therapy for depression in unipolar and bipolar disorder
This study tests how well light therapy works for moderate to severe depression in people with or without bipolar disorder. It includes a possible MRI brain scan to understand how light affects the brain. You must not have certain eye conditions or high suicide risk.
ParisAges 18–65 - NCT06797804Recruiting
Horticultural therapy for older adults in long-term care
This study tests if an app-guided gardening program can improve heart health, reduce stress and depression, and boost happiness in older adults living in nursing homes. It aims to see if these sessions can help you feel better overall.
TaipeiAges 65 years+ - NCT05637320Recruiting
Therapy study for children’s big emotions and mood
This study looks at how children’s emotions change during therapy for concerns like anxiety, depression, or disruptive behavior. It may help you and your child understand what kinds of therapy support might work best.
Guelph, OntarioAges 8–15 - NCT07449676Recruiting
Tui Jing therapy for depression study
This study tests a gentle hands-on therapy based on Traditional Chinese Medicine, called Tui Jing, to see if it improves mood and brain function in people with depression. It lasts 12 weeks and compares the therapy with a placebo.
Hong Kong, Hung HomAges 18–55 - NCT07444242Recruiting
Fast depression treatment using brain stimulation
This trial tests whether a non-invasive brain stimulation technique called tDCS can quickly improve depression symptoms. It is for people who are not taking any psychiatric medications now or in the past.
Regensburg, BavariaAges 18–70 - NCT06812923Recruiting
tACS for hard‑to‑treat depression with inflammation
This study tests a non‑invasive brain stimulation method called tACS (transcranial alternating current stimulation) for people with difficult‑to‑treat depression and signs of inflammation. It aims to see if this treatment can help when standard medications haven't worked well enough.
Tianjin, Tianjin MunicipalityAges 18–55 - NCT07430774Recruiting
Depression, emotions, and heart rate in teens
This study looks at how your relationship with your parent and your emotions affect your heart rate and depression. You will wear a Fitbit for a week and answer questionnaires about your feelings and daily habits.
Dallas, TexasAges 12–18 - NCT07423273Recruiting
Hyperbaric oxygen therapy for post-stroke depression
This study tests if breathing pure oxygen in a special chamber (hyperbaric oxygen therapy) can help people who have been depressed since having a stroke. It may offer a new way to treat depression that hasn't improved with standard medications.
ZrifinAges 50–85 - NCT07422909Enrolling by invitation
Bridging the gap: adding exercise to depression treatment for teens
This trial tests if adding physical activity to standard depression care helps teens feel better. It's for teens ages 12 to 19 in Brussels who are not very active now.
Brussels, UccleAges 12–19 - NCT06823492Recruiting
Early life and brain study
This study looks at how your early life experiences may affect your brain and behavior. You would visit the University of Manchester for assessments and help researchers understand these connections.
ManchesterAges 18–25
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,419 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.