Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,510 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07022405RecruitingPhase 2
Medication study for depression with brain scans
This study tests whether a targeted medication can improve mood and brain function in adults with major depression. If you qualify, you'll receive a study drug and have fMRI brain scans to see how your brain responds.
Palo Alto, CaliforniaAges 18–65 - NCT07022925Recruiting
Wearable device for tracking hot flushes in perimenopause
This study will test if a wearable device can accurately track symptoms like hot flushes and night sweats in women going through perimenopause. If you are between 35 and 55 and experiencing these symptoms, your participation could help improve future symptom monitoring.
London, OntarioAges 35–55 - NCT07721753Recruiting
Online exercise and therapy for breast cancer mood
This study tests an online program that combines fun video-game exercises with talk therapy to help breast cancer patients who feel depressed or anxious. It takes place in Malaysia and is for Chinese-speaking adults.
Xinxiang, HenanAges 18 years+ - NCT07039370Recruiting
TMS for depression: looking for brain signals of response
This trial tests if brain scans or electrical signals can predict who will get better with TMS (transcranial magnetic stimulation) for depression. It is for people whose depression did not improve after trying two or more antidepressants.
Ankara, AnkaraAges 18–65 - NCT06097221Recruiting
Advancing sleep timing to improve depression
This trial tests whether advancing your sleep timing (going to bed and waking up earlier) can improve depression symptoms. It is for people recently discharged from a psychiatric hospital who have a delayed sleep schedule.
Copenhagen, FrederiksbergAges 18 years+ - NCT06095310Recruiting
Understanding severe depression in hospitalized patients
This study looks at the clinical and psychiatric features of severe depression in adults who are hospitalized. It aims to better understand the condition and improve care.
LilleAges 18 years+ - NCT07500064Recruiting
tDCS Brain Stimulation for Depression
This trial tests a gentle, non-invasive brain stimulation treatment (called tDCS) for adults with depression. It uses a mild electrical current on the scalp to help improve mood and thinking.
Hefei, AnhuiAges 18–65 - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT07304219Enrolling by invitation
Physical activity program for depression and anxiety in teens
This study tests whether a physical activity program can help young people with depression or anxiety feel better. If you are already receiving care at Haukeland's child and adolescent clinic, you might be able to join a group program designed to boost your mood and reduce anxiety.
Bergen, VestlandAges 8–18 - NCT07279311Enrolling by invitation
Virtual reality for depression during high-risk pregnancy
This study tests if virtual reality (VR) exercises can help reduce depression symptoms in pregnant people who must stay in the hospital for at least 3 weeks due to complications. If you are feeling down and are able to use VR, this treatment might offer a new way to feel better.
Palo Alto, CaliforniaAges 18 years+ - NCT07294274Recruiting
Predicting depression risk after a stroke
This study creates a tool to predict if someone might develop depression after an ischemic stroke. It aims to help doctors identify and support patients who are at higher risk.
ChongqingAges Any age - NCT07247968RecruitingEarly Phase 1
Esketamine with ECT for severe depression in teens
This study tests whether adding a low dose of esketamine (a type of anesthesia) to modified electroconvulsive therapy (ECT) helps treat severe depression in teenagers. It aims to see if this combination works better and is safer than ECT alone.
ChongqingAges 13–17 - NCT07172113Recruiting
Virtual Reality Therapy for Depression in Young Adults
This study tests a virtual reality program that delivers cognitive behavioral therapy (a type of talk therapy) to help young adults with depression. If you are a native Cantonese speaker between 18 and 40, you may be able to try this new digital therapy from home.
Hong KongAges 18–40 - NCT07532551Recruiting
Online Therapy for Anxiety and Depression in Singapore
This study tests an internet-based cognitive behavioral therapy (a self-guided online mental health program) for people with mild-to-moderate anxiety or depression. You'd use an app on your phone or computer to work through lessons and exercises designed to help manage these feelings.
SingaporeAges 21 years+ - NCT07294924Recruiting
Predicting depression treatment response with brain imaging
This study uses a special brain-imaging headband to see if it can predict how well people with depression respond to a treatment called accelerated rTMS (a type of brain stimulation). It compares results with people who do not have depression.
Los Angeles, CaliforniaAges 18–75 - NCT07745374Recruiting
Deep brain stimulation for bipolar depression
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, is safe and feasible for people with bipolar depression that hasn't improved with other treatments. It may offer a new option for those who have exhausted standard therapies.
New York, New YorkAges 22–70 - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Phoenix, ArizonaAges 18–74 - NCT07076407RecruitingPhase 3
Testing a new antidepressant pill for depression
This study tests an experimental oral pill called azetukalner against a placebo to see if it safely reduces symptoms of major depressive disorder. It is for adults who are currently in a depressive episode lasting 6 weeks to 2 years and have not already tried multiple antidepressants that failed.
Dothan, AlabamaAges 18–74 - NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
Phoenix, ArizonaAges 18 years+ - NCT06795451RecruitingPhase 1/Phase 2
Spinal stimulation for depression: a clinical trial
This study tests if a non-invasive spinal stimulation device can improve depression symptoms. It is for people currently taking an antidepressant for at least 8 weeks but still experiencing depression.
Mason, OhioAges 18–60 - NCT05567640Recruiting
Smart digital mental health support
This study tests a digital mental health program that uses smart technology to personalize your experience and keep you engaged. If you join, you may get a more tailored approach to improving your mental well-being.
Boston, MassachusettsAges 18 years+ - NCT05828056Recruiting
Predicting mood episodes in bipolar disorder with a smartwatch
This study uses a smartwatch and smartphone to track daily patterns and predict when manic or depressive episodes might happen in people with bipolar disorder. It aims to help patients and doctors better manage the condition.
TaipeiAges 20–60 - NCT07227454RecruitingPhase 3
Esketamine for teens with severe depression and suicidal thoughts
This trial tests if esketamine (a nasal spray) can quickly reduce symptoms of major depression and suicidal thoughts in teenagers who need urgent hospital care.
Birmingham, AlabamaAges 12–17 - NCT07573176RecruitingPhase 3
Seltorexant for Depression in Adults and Older Adults
This study tests a new medication called seltorexant as a standalone treatment for major depression. The trial is for adults and older adults who have depression that hasn't improved with other antidepressants or who haven't tried them yet.
Bellflower, CaliforniaAges 18–74
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,510 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.