Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05607654Recruiting
Brain stimulation for depression that hasn’t improved with usual treatment
This study tests how a specific kind of brain stimulation (repetitive transcranial magnetic stimulation) works for people with depression that has not responded to standard treatments. If you qualify, it may help doctors understand the mechanism and improve options for treatment-resistant depression.
Hangzhou, ZhejiangAges 18–45 - NCT05617495Recruiting
Mindfulness training with brain scans for depression
This study tests a mindfulness-based program combined with “brain scan feedback” (fMRI neurofeedback) to see if it can help teenagers and young adults with major depression. It may help by teaching skills and tracking brain activity changes during treatment.
Boston, MassachusettsAges 13–18 - NCT05630963Recruiting
Study sleep-like brain signaling in major depression
This trial looks at how a specific brain receptor related to pain signals (nociceptin/orphanin FQ receptor) may be involved in depression. It may help researchers understand depression better by comparing people with current versus past (remitted) major depression.
Belmont, MassachusettsAges 18–45 - NCT05637320Recruiting
Therapy study for children’s big emotions and mood
This study looks at how children’s emotions change during therapy for concerns like anxiety, depression, or disruptive behavior. It may help you and your child understand what kinds of therapy support might work best.
Guelph, OntarioAges 8–15 - NCT05640089Recruiting
Brain training with fMRI feedback for depression
This trial tests whether using real-time brain scan feedback (fMRI neurofeedback) can help reduce depressive symptoms. You may be eligible if you have depression that is still active despite being on antidepressant medicine.
MaastrichtAges 18 years+ - NCT05644301RecruitingPhase 3
Blood-marker guided add-on treatment for major depression
This study tests whether doctors can choose the best add-on immune-related treatment for people with major depressive disorder by using inflammation blood tests. It’s meant for people whose depression has not improved enough with their current antidepressant.
Duffel, AntwerpenAges 18–65 - NCT05649800Recruiting
Study brain and blood-vessel changes in older adults after stroke
This study looks at how blood flow in the brain and related brain processes change after stroke, especially when someone also has conditions like dementia, depression, or delirium. It may help researchers understand what drives these problems and how they connect.
Leicester, LeicestershireAges 65 years+ - NCT05660642RecruitingPhase 2
Safety and tolerability study for BPL-003 in hard-to-treat depression
This Phase 2 study tests BPL-003 in people with treatment-resistant depression to learn about its safety and how it affects the body and brain. Because it is open-label, everyone knows they are getting the study treatment, and you’ll also need to stop your current antidepressant during the study.
LiverpoolAges 18–75 - NCT05661383Recruiting
Smell and brain stimulation for hard-to-treat depression
This trial studies whether stimulating the brain and senses related to smell can reduce symptoms in people with depression that has not responded to usual treatment. It may help by testing new non-drug approaches for improving mood and motivation.
BronAges 18 years+ - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT05703256Recruiting
Brain training with feedback to help depression
This trial tests a type of brain training called amygdala neurofeedback to reduce depression symptoms. It may help by teaching your brain patterns to become less “stuck” in depression-related activity.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05745194Recruiting
Mediterranean diet study for depression with inflammation
This study tests whether a Mediterranean-style diet can improve depression symptoms in people who have depression and higher inflammation in their blood. It may help by targeting nutrition-related inflammation that can worsen mood for some people.
Loures, Lisbon DistrictAges 18–70 - NCT05754151Recruiting
Mobile therapy for anxiety and depression in adults 40+
This trial tests whether a phone or tablet version of cognitive behavioral therapy (CBT) can help people ages 40 and older with anxiety or depression. It may help you manage symptoms with skills you can use between sessions.
New York, New YorkAges 40 years+ - NCT05757791RecruitingPhase 2
Testing an SGLT2 diabetes drug for depression
This Phase 2 trial tests whether an SGLT2 medicine (like empagliflozin) can reduce symptoms of major depression. It may help people with moderate-to-severe depression who are otherwise eligible for the study.
New York, New YorkAges 18–65 - NCT05766475Recruiting
In-person vs virtual postpartum depression prevention groups
This study compares two ways of delivering a group program to help prevent postpartum depression—either in person or online. If you’re pregnant and speak English or Spanish, you may be able to join the program and help researchers learn which format works best.
Denver, ColoradoAges 18 years+ - NCT05772897Recruiting
Parenting group for mothers with postpartum depression
This study offers a structured parenting skills group to help mothers’ mood after having a baby. It also includes some mothers without current depression symptoms for comparison, to better understand what helps.
Denver, ColoradoAges 18–50 - NCT05773755Recruiting
Brain stimulation surgery for treatment-resistant depression
This trial studies whether deep brain stimulation (DBS)—a surgically placed brain device—can reduce severe, long-lasting depression that hasn’t responded to many treatments. It may help people whose depression has persisted despite trying multiple antidepressant and other evidence-based therapies.
New York, New YorkAges 25–70 - NCT05786066RecruitingPhase 2
Test whether blocking AMPA changes ketamine’s suicide relief
This study looks at whether an “AMPA receptor blocker” changes how ketamine affects suicidal thoughts in people with depression that hasn’t improved with usual treatments. If you qualify, you may receive ketamine and the study medicine, while continuing your regular mental health care.
West Haven, ConnecticutAges 21–65 - NCT05798143Recruiting
Testing brain-signal biomarkers in treatment-resistant depression
This trial studies signs in the brain (biomarkers) during an accelerated form of nerve stimulation to treat depression that hasn’t improved with usual antidepressants. It may help researchers learn who benefits and how to better personalize treatment.
ChietiAges 18–65 - NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Toronto, OntarioAges 20–65 - NCT05849038RecruitingPhase 2
Treating inflammation to improve depression in HIV
This Phase 2 study looks at whether lowering inflammation can help improve depression symptoms in adults living with HIV. You may be able to join if your HIV is well controlled and you are currently experiencing major depression (or a certain type of bipolar depression).
Atlanta, GeorgiaAges 18–65 - NCT05866575Recruiting
Brain-modeling trial to predict depression treatment response
This trial uses computer modeling based on brain measurements to try to predict which depression treatment will work for you. It may help match you with the most effective option faster by understanding your motivation-related brain patterns.
La Tronche, IsèreAges 18 years+ - NCT05866991Recruiting
Study tracking sleep and mood in depression
This study looks at people with a current episode of major depression and measures sleep and daily body-clock patterns, along with other mental health symptoms. They may help researchers better understand how sleep and mood changes relate, which could improve future care.
ParisAges Any age - NCT05874362Recruiting
Study grief after violent loss and how time is perceived
This study looks at how people who recently lost a close family member to a violent death experience grief, including how they perceive time. It may help researchers understand these effects and better plan future support for bereaved people.
BronAges 18–65
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,509 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.