Clinical trials
Depressed clinical trials
Below are recruiting depressed clinical trials, each written for real people, not researchers. We’re tracking 1,509 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05877885Recruiting
Digital treatment for low motivation in older adults with depression
This study tests a digital therapy to improve apathy (feeling unmotivated or “checked out”) in people age 60+ who have depression. It also uses brain imaging (MRI) and questionnaires to see whether the treatment helps brain function linked to motivation.
Orlando, FloridaAges 60 years+ - NCT05892965Recruiting
Instant-message online therapy for early post-stroke depression
This study tests whether brief online cognitive behavioral therapy (CBT) delivered through instant messages can reduce depression symptoms after a stroke. It may help if your depression started after your stroke and you have mild to moderately severe symptoms.
Hong KongAges 18 years+ - NCT05895747RecruitingPhase 2
5-HTP and creatine for adults with depression symptoms
This Phase 2 study tests whether adding 5-HTP and creatine can reduce depression symptoms in adults with major depressive disorder. It may help if your current depression treatment hasn’t been fully effective and you meet the safety and medical criteria.
Salt Lake City, UtahAges 18–65 - NCT05900271Recruiting
Trial for depression using new brain-stimulation sessions
This study tests whether a specific type of brain stimulation (theta burst delivered over several days) works better than standard rTMS given over 6 weeks for people with treatment-resistant depression. It may help improve depressive symptoms, measured with multiple depression rating scales.
Nijmegen, GLAges 18–99 - NCT05909267Recruiting
Testing dopamine-targeted treatment for depression and body inflammation
This study looks at how changing dopamine signaling may affect motivation and movement in people with major depression, and it also involves healthy volunteers. It may help researchers understand whether dopamine changes can improve symptoms and how inflammation may relate to brain function.
SteglitzAges 18–65 - NCT05913947RecruitingPhase 4
Lithium or cariprazine for bipolar depression
This trial compares lithium versus cariprazine to treat an episode of depression in people with bipolar disorder. It may help find which medicine works better and is safer during the acute (active) phase of depression.
AalborgAges 18–65 - NCT05915013RecruitingPhase 1
Brain-targeting study of ketamine response in treatment-resistant depression
This early-stage study looks at how parts of brain cells respond to ketamine in people with depression who have not improved with usual antidepressants. It may help researchers find why ketamine works for some people and not others, and who might benefit.
New Haven, ConnecticutAges 18–60 - NCT05952674Recruiting
Vagus nerve stimulation for long-term depression symptoms
This trial studies whether a device that stimulates the vagus nerve (VNS) can help people with treatment-resistant depression or related mood disorders that have not improved despite multiple therapies. It may help by targeting mood symptoms when other treatments haven’t worked well.
Angers, FranceAges 18 years+ - NCT05961306Recruiting
Testing a stepped screening plan during pregnancy and after birth
This study checks how well a step-by-step screening approach and its tools work for identifying issues during pregnancy (weeks 20–24) or in early postpartum (6–10 weeks after delivery). It may help doctors use more accurate screening to decide who needs further care.
Ghent, Oost-VlaanderenAges 18 years+ - NCT05962216Recruiting
Real-world check of Rexulti for schizophrenia and depression
This study looks at how well brexpiprazole (Rexulti) works in everyday treatment, and how people feel and function over time. You may be eligible if you’re newly started on Rexulti and have a qualifying mental health diagnosis.
Hong KongAges 18–65 - NCT05973786RecruitingPhase 3
Six-week medicine boost for bipolar depression after first treatment fails
This trial tests whether a stronger, more active medication plan for six weeks helps people with bipolar depression who did not improve with their first prescribed treatment. It compares the intensified medication plan to usual care to see which approach works better.
InnsbruckAges 18 years+ - NCT05988333Recruiting
Family support program for major depression
This trial tests a psychoeducational program for families living with a person who has major depression. It aims to help everyone understand the illness and improve coping.
NaplesAges 18–65 - NCT06022913Recruiting
Behavioral activation therapy for bipolar depression
This trial tests a therapy called behavioral activation to help people with bipolar depression feel better. The therapy focuses on increasing positive activities and routines to improve mood.
ReykjavikAges 18 years+ - NCT06050070Recruiting
Using Real-Time Brain Imaging to Help Depression
This study tests whether real-time brain imaging (fMRI) can help people with depression learn to change their brain activity. You will receive feedback on your brain signals while thinking positive or neutral thoughts.
Ann Arbor, MichiganAges 18–55 - NCT06054321Recruiting
Depression medication study for adults 19 to 65
This study tests a new way of choosing antidepressants for people with major depression. It's designed for adults aged 19–65 who have moderate to severe depression and are either starting a new antidepressant or have been off psychiatric meds for at least a month.
GwangjuAges 19–65 - NCT06074250RecruitingPhase 2/Phase 3
Pregnancy, mood, and gut health study
This study tests whether a nutritional supplement can help prevent depression and anxiety during and after pregnancy. It looks at how the mother's gut bacteria may influence mood.
Toronto, OntarioAges 18–43 - NCT06076317Recruiting
Telemedicine monitoring for depression after hospitalization
This trial tests whether regular video check-ins with a psychiatrist can improve recovery after a hospital stay for depression. You may be eligible if you started or changed an antidepressant or anti-anxiety medication while in the hospital and can use a computer or smartphone for video calls.
ParisAges 18 years+ - NCT06078007Recruiting
App for depression and anxiety in college students
This trial tests if a guided mobile app can help college students with mild to moderate depression or anxiety. You might benefit if you are not currently receiving mental health treatment and have a smartphone.
Palma de Mallorca, Balearic IslandsAges 18 years+ - NCT06085950Recruiting
Ultrasound brain stimulation for hard-to-treat depression
This trial tests whether a gentle ultrasound treatment aimed at the brain can help people with severe depression that hasn't improved with at least two prior medications. It's a first small study to see if the approach is safe and promising.
ParisAges 18–75 - NCT06088732RecruitingPhase 1/Phase 2
Exercise and ibuprofen for bipolar depression
This study tests whether acute exercise and ibuprofen can improve symptoms of bipolar depression by studying their effects on the immune system and brain circuits. It may help if you are currently in a depressive episode and can do moderate physical activity.
Tulsa, OklahomaAges 18–55 - NCT06090422RecruitingPhase 1/Phase 2
Ketamine for depression and alcohol use disorder
This trial tests if ketamine can help people who have both depression and alcohol use disorder. You must be currently sober, have at least moderate depression, and be admitted to the hospital for addiction treatment.
TromsøAges 18–65 - NCT06096207RecruitingPhase 1
Deep brain stimulation for severe depression
This trial tests whether deep brain stimulation (DBS) — a surgical treatment that uses tiny electrical pulses to change brain activity — can help people with severe, long-lasting depression that hasn't responded to other treatments.
Queens, New YorkAges 18–65 - NCT06110897Recruiting
Resistance Exercise for Depression Trial
This study tests whether resistance exercise (like lifting weights) can help reduce depression symptoms. If you have major depression and are not already doing regular resistance training, you may be able to join.
Ames, IowaAges 18–65 - NCT06129890Recruiting
Brain stimulation for nerve pain and depression
This trial tests whether a noninvasive brain stimulation technique (rTMS) can help people with long-term nerve pain who also have depression. It aims to see if this treatment can reduce pain and improve mood.
Saint-EtienneAges 18–85
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Common questions
- Are there clinical trials for depressed?
- Yes. Clin2 currently lists 1,509 recruiting depressed studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressed trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressed trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.