Clinical trials
Depression and Anxiety Symptom clinical trials
Below are recruiting depression and anxiety symptom clinical trials, each written for real people, not researchers. We’re tracking 165 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06455397Recruiting
Building emotional awareness and mental health for parents
This trial tests a program called BEAM that helps parents and caregivers of young children (ages 2–5) manage stress, depression, anxiety, or anger. You'll get support from a peer coach through check-ins and learn skills to feel better.
Winnipeg, ManitobaAges 18 years+ - NCT06899165RecruitingPhase 2
Psilocybin therapy for inherited trauma
This trial tests whether psilocybin (a psychedelic substance) combined with therapy can help adult children of genocide survivors who experience symptoms of trauma, depression, or anxiety. The goal is to see if this approach can reduce the emotional impact of intergenerational trauma.
New York, New YorkAges 18 years+ - NCT06722781Recruiting
Online group therapy for common mental health conditions
This trial tests an online group therapy for people waiting for high intensity CBT. It aims to provide quicker support for conditions like depression, anxiety, and PTSD.
Doncaster, South YorkshireAges 17 years+ - NCT06266611RecruitingPhase 2
Cannabis for cancer symptom relief
This trial tests whether cannabis can help cancer patients manage symptoms like sleep trouble, pain, and mood changes. It's for people who are new to using cannabis for these issues.
Aurora, ColoradoAges 25 years+ - NCT06538246Recruiting
Coping skills training for heart and lung failure survivors
This study tests a coping skills training program to help people who recently survived a serious heart or lung problem feel less anxious, depressed, or stressed. If you were in the ICU and now feel distressed at home, you may be able to join.
Durham, North CarolinaAges 18 years+ - NCT06399991Recruiting
Improving mental health care in Malawi clinics
This study is testing a new way to help clinics in Malawi better support patients with mental health needs. If you are an adult patient at a participating clinic who has recently had symptoms of depression or anxiety, you may be eligible.
ChiradzuluAges 18 years+ - NCT06290778Enrolling by invitation
Mental health prevention training for fire fighter trainees
This study tests a program where peers teach emotion regulation skills to help prevent mental health issues in new fire fighters. You would be asked to complete surveys and attend training sessions.
Waco, TexasAges 21 years+ - NCT06236919Recruiting
Virtual reality for emotional regulation in kids and teens
This study tests a virtual reality program designed to help children and teens learn to manage their emotions. It's offered in schools and aims to improve emotional regulation skills.
BarcelonaAges 10–16 - NCT06226155Recruiting
HIV prevention support for pregnant women in Zimbabwe
This study in Zimbabwe tests a program to help pregnant women start and stay on PrEP (medication that prevents HIV). It aims to make PrEP easier to use during pregnancy for women who are at risk of HIV.
HarareAges 15–55 - NCT06162741Recruiting
Brief mindfulness training for Veterans in primary care
This study tests whether brief mindfulness training offered in VA primary care can help Veterans with symptoms of PTSD, depression, or anxiety. It aims to see if this approach works well in everyday clinic settings.
Phoenix, ArizonaAges 18 years+ - NCT06004414Recruiting
SilverCloud mental health app study for high school students
This study tests a mental health app called SilverCloud in high school students who are feeling anxious or depressed. It aims to see if the app can help improve their mood and wellbeing.
New Brunswick, New JerseyAges 13–22 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05323864Recruiting
Altitude exposure study for anxiety and low mood
This trial looks at what happens to people with anxiety and depressive symptoms after going to high altitude with low oxygen. It may help researchers understand whether altitude affects these symptoms and how it might be managed.
Innsbruck, TyrolAges 18–65 - NCT05434130RecruitingPhase 1/Phase 2
Testing the right exercise amount to help concussion recovery
This study tests whether adjusting how much exercise you do can improve recovery after a concussion. You may be screened to make sure symptoms are still present, and then assigned to an exercise plan that matches the study’s goals.
Aurora, ColoradoAges 13–18 - NCT05426057Recruiting
Mental health support for Hispanic teens with caregiver involvement
This study looks at improving mental health in primary care by involving both a teen and an adult caregiver. It may help families who are struggling with communication, depression or anxiety symptoms, or past suicidal thoughts or behaviors.
Miami, FloridaAges 12–16 - NCT05333627Recruiting
Online therapy program trial for student depression or anxiety
This trial tests an internet-based therapy program to help students with depression or anxiety. If you qualify, you’ll complete online sessions and assessments to see whether the program helps with symptoms and how long you prefer to use it.
Regina, SaskatchewanAges 18 years+ - NCT04335487Recruiting
Online therapy program for PTSD symptoms in public safety workers
This study tests an internet-based cognitive-behavioral therapy (an online talk-therapy style program that helps you manage thoughts and feelings) to reduce PTSD symptoms in public safety personnel. You may be able to join if you have PTSD-like symptoms and can safely take part in online treatment.
Regina, SaskatchewanAges 18 years+ - NCT04106713Recruiting
Understanding change across different psychotherapies for anxiety and depression
This study looks at how people change during different types of psychotherapy for anxiety and depression. It aims to understand which treatments work best for different people.
Singapore, SingaporeAges 18–99 - NCT04127032Recruiting
Online therapy program for public safety workers’ stress and mood
This trial tests an internet-delivered cognitive behavioral therapy (an online talk-and-skills program) to help public safety personnel with symptoms of anxiety, depression, or post-traumatic stress. If you’re eligible, you may receive structured online support aimed at reducing distress and improving coping.
Regina, SaskatchewanAges 18 years+ - NCT06948903Recruiting
Fibromyalgia, brain sensitivity and thinking
This study looks at how the brain's pain sensitivity (central sensitization) relates to memory and thinking problems in people with fibromyalgia. Participating could help doctors understand and treat these symptoms better.
Istanbul, UskudarAges 18–65 - NCT07682064Recruiting
Group therapy for emotional disorders in adults
This trial tests a group therapy program for adults with emotional disorders like depression or anxiety. It is designed to help you manage difficult emotions and improve your well-being.
Logroño, La RiojaAges 18–65 - NCT07107906Recruiting
CONNECT program: group telehealth to reduce loneliness in adults 55+
This trial tests a group-based telehealth program called CONNECT, which aims to reduce loneliness, social isolation, and mental health symptoms like anxiety or depression in adults aged 55 and older. You'll join online group sessions instead of in-person programs, making it easier to connect from home.
Winnipeg, ManitobaAges 55 years+ - NCT05925322Recruiting
Social reward therapy for depression-related suicidal thoughts
This study looks at whether “social reward” psychotherapy can change brain activity and reduce suicidal thoughts in adults ages 50–80 who also have major depression. You may be offered psychotherapy along with brain scans to see how your brain responds over time.
New York, New YorkAges 50–80 - NCT07878286Recruiting
How body awareness relates to fibromyalgia symptoms
This study looks at how well women with fibromyalgia notice internal body signals (like heartbeat or breathing) and whether that affects their pain and other symptoms. It may help doctors understand fibromyalgia better and improve future treatments.
IstanbulAges 18–65
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Common questions
- Are there clinical trials for depression and anxiety symptom?
- Yes. Clin2 currently lists 165 recruiting depression and anxiety symptom studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression and anxiety symptom trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression and anxiety symptom trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.