Clinical trials
Depression, Anxiety clinical trials
Below are recruiting depression, anxiety clinical trials, each written for real people, not researchers. We’re tracking 441 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05897619Recruiting
CBT skills app for pregnancy and postpartum stress and coping
This study tests whether a new phone app that teaches “cognitive behavioral therapy” (CBT) skills is helpful and easy to use for people who are pregnant or recently gave birth. It also checks safety and whether participants feel the app is acceptable to use over time.
New York, New YorkAges 18 years+ - NCT05868135Recruiting
Online guided therapy for depression and anxiety
This trial tests an internet-based (online) guided psychological program, called e-Meistring, for people with moderate depression plus panic disorder and social anxiety. It aims to see whether the program improves symptoms and is also worth the cost.
BergenAges 18 years+ - NCT05836090Recruiting
Family Spirit Strengths program for pregnant people and caregivers
This trial tests a family-focused program to support mental health and reduce risks related to substance use. It may help you if you’re pregnant or caring for a child 24 months or younger and you’re experiencing depression/anxiety and/or substance-use risk.
Chinle, ArizonaAges 14 years+ - NCT05802004Recruiting
Sound stimulation to improve sleep and emotions in young adults
This study tests whether gentle sound stimulation during sleep can improve sleep and how you think and feel in daily life when you have anxiety or depression symptoms. You’ll also do sleep testing in a lab and complete questionnaires to measure changes.
Pittsburgh, PennsylvaniaAges 18–25 - NCT05569018Recruiting
Spanish blended group therapy for anxiety and depression symptoms
This study tests whether a group therapy program delivered in both online and in-person formats can reduce emotional symptoms like anxiety and depression. If you qualify, you may be assigned to receive this structured group treatment during the study period.
Castellon, CastellónAges 18 years+ - NCT05447689Recruiting
Group mind-body skills for anxious graduate students
This trial offers a weekly group program teaching mind-body skills to help reduce anxiety. It’s for graduate students who screen as having moderate or higher anxiety and can attend meetings regularly.
White Plains, New YorkAges 18 years+ - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05437705Recruiting
Brain scan and stimulation study for low mood
This study uses brain imaging (MRI) and a brain-stimulation method (TMS) to understand and possibly change brain patterns linked with low mood. You may be eligible if you have moderate to severe depression symptoms and can safely complete the scans and stimulation sessions.
Philadelphia, PennsylvaniaAges 18–65 - NCT05371470Enrolling by invitation
Smartphone voice analysis to track depression and anxiety in rehab
This study tests whether a smartphone app that listens to your voice can detect changes in depression and anxiety while you’re in cardiac rehabilitation. If it works, it may help people get timely support during recovery.
Rochester, MinnesotaAges 18 years+ - NCT05156385Recruiting
Study of sexual problems in women with treated high blood pressure
This study looks at sexual dysfunction (sexual problems) in women who are being treated for high blood pressure. It may help researchers understand what causes these issues and what could improve them.
Toulouse, CHU de ToulouseAges 18 years+ - NCT07146503Recruiting
Esketamine Nasal Spray for Treatment-Resistant Depression in Real Life
This study tests esketamine nasal spray (a fast-acting antidepressant) for people with treatment-resistant depression who haven't gotten better after trying at least two other antidepressants. It looks at how well the spray works in everyday doctor's offices, not just in research clinics.
Genova, GeAges 18–74 - NCT06682689Recruiting
Nerve stimulation study for new mothers' mental health
This study tests whether a gentle nerve stimulation device (tVNS) worn on the ear can help new mothers feel better emotionally after childbirth. It is for women whose babies had normal organ scans and who do not have certain medical conditions or current mood disorders.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07571226Recruiting
Urban Stress and Mental Health Monitoring Study
This study explores how city living and daily stress affect depression, anxiety, and alcohol use disorders by having you wear a monitoring wristband and use a smartphone app to track your physical responses. Researchers hope to better understand the link between environmental stress and mental health symptoms.
BeijingAges 18–60 - NCT07538427Recruiting
Music Therapy for Health in Rural Elder Care
This study explores whether music can improve health and wellbeing in older adults living in rural care facilities. Researchers will work with residents to understand how music might help with mood, memory, and quality of life.
Flagstaff, ArizonaAges Any age - NCT07305701Recruiting
Study on Medical Students' Mental Health
This study follows first-year health students at the University of Orléans to understand their mental health over time. It aims to find ways to support students' well-being during their studies.
Orléans, LoiretAges 18 years+ - NCT07239609RecruitingPhase 1
ACT therapy for memory loss and their caregivers
This study tests if ACT, a type of talk therapy, helps people with mild memory loss and their care partners cope with difficult emotions. Both you and a family member or friend who helps you would participate.
Lubbock, TexasAges 18 years+ - NCT07138664Recruiting
Mental health program for teens in Malaysia
This trial tests a program to help young teenagers in Malaysia who are experiencing anxiety or depression. The program aims to improve mental health and well-being.
Kota Kinabalu, SabahAges 12–14 - NCT06175104Recruiting
HeartGPS: Support for parents after a prenatal heart diagnosis
This study tests a counseling program for parents whose unborn baby has a serious heart condition called single ventricle. The program aims to help parents manage stress and support their baby's development before and after birth.
Los Angeles, CaliforniaAges 18 years+ - NCT06768749Recruiting
Melatonin lotion for better sleep and mood
This trial tests whether using a scented melatonin lotion before bed can improve sleep and reduce anxiety or depression symptoms. It may be a good fit if you have mild sleep problems and some mood symptoms but are not currently taking medication for them.
Redlands, CaliforniaAges 18–21 - NCT06722287Recruiting
Phone support for family caregivers in Thailand
This study tests a mobile program to support the mental health of family caregivers in Thailand. You participate from home using your phone.
BangkokAges 18–80 - NCT06633458Recruiting
Family communication in teen psychiatric care
This trial looks at how teens in a hospital psychiatry unit feel about talking with their parents and whether that affects their treatment progress.
Hamburg, Free and Hanseatic City of HamburgAges 14–17 - NCT06274112Recruiting
Using brain stimulation to understand social motivation in depression or social anxiety
This study uses transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, to explore how the brain processes social motivation in people with major depressive disorder or social anxiety disorder. Understanding these brain processes could help develop new treatments for social avoidance.
Auburn, AlabamaAges 25–50 - NCT06073886RecruitingPhase 2
Better brain stimulation for long-lasting concussion symptoms
This trial tests whether personalized brain stimulation can help people who have ongoing symptoms more than 20 on a standard concussion scale, such as headaches, dizziness, or trouble concentrating, after a mild head injury in the past year.
Westwood, Los Angeles, CaliforniaAges 18–65 - NCT05232032RecruitingPhase 2
Brain scan and medication study for avoiding versus approaching
This Phase 2 study looks at how a medication affects brain activity and real-life mood or anxiety behaviors. It includes people with major depression or several anxiety disorders and also healthy volunteers, using questionnaires, a smartphone, and brain imaging.
Belmont, MassachusettsAges 18–45
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Common questions
- Are there clinical trials for depression, anxiety?
- Yes. Clin2 currently lists 441 recruiting depression, anxiety studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depression, anxiety trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depression, anxiety trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.