Clinical trials · New York
Depression Disorders clinical trials in New York
We’re tracking 64 recruiting depression disorders studies with a site in New York — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in New York
- NCT05757791RecruitingPhase 2
Testing an SGLT2 diabetes drug for depression
This Phase 2 trial tests whether an SGLT2 medicine (like empagliflozin) can reduce symptoms of major depression. It may help people with moderate-to-severe depression who are otherwise eligible for the study.
New York, New YorkAges 18–65 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Brooklyn, New YorkAges 18–65 - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Mount Kisco, New YorkAges 18 years+ - NCT06559306RecruitingPhase 3
Seltorexant for depression with insomnia symptoms
This trial tests if adding seltorexant to your current antidepressant can improve depression and sleep problems. It is for people with major depressive disorder who still have symptoms, especially insomnia, despite trying at least one antidepressant.
Brooklyn, New YorkAges 18–74 - NCT07572526Recruiting
Brain Stimulation to Improve Sleep and Mood in Depression
This study tests a non-invasive brain stimulation technique called tDCS (transcranial direct current stimulation) to see if improving sleep can help reduce depression symptoms. You'll do short stimulation sessions at home and track your sleep and mood.
New York, New YorkAges 18–65 - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
New York, New YorkAges 18–68 - NCT07076407RecruitingPhase 3
Testing a new antidepressant pill for depression
This study tests an experimental oral pill called azetukalner against a placebo to see if it safely reduces symptoms of major depressive disorder. It is for adults who are currently in a depressive episode lasting 6 weeks to 2 years and have not already tried multiple antidepressants that failed.
Mount Kisco, New YorkAges 18–74 - NCT05466851Recruiting
Study testing anxiety and depression biology and therapy markers
This study looks at “biopsychosocial markers” (biological, psychological, and social signs) in people with major depression and/or anxiety. It aims to understand what changes with treatment and how those changes connect to symptoms like anxiety and depression.
New York, New YorkAges 18–65 - NCT06752759RecruitingPhase 3
Ketamine mist for depression
This trial tests if a ketamine mist you breathe in can help treat moderate to severe depression. It is for adults who are not helped enough by other treatments.
Brooklyn, New YorkAges 18–88 - NCT06835855Recruiting
Does mother’s depression affect baby’s attention to emotions?
This study looks at how babies of mothers with depression pay attention to emotional faces. Researchers want to learn if these babies show different patterns of attention to happy or sad cues, which could help understand early development.
Binghamton, New YorkAges 6 months+ - NCT04041479RecruitingPhase 3
Brain-scan guided rTMS for treatment-resistant depression
This trial tests whether using brain-related “biomarkers” from your scans to guide rTMS can improve depression that hasn’t responded to at least one antidepressant. It may help by targeting brain circuits linked to depression more precisely.
New York, New YorkAges 22–65 - NCT06938841Recruiting
Maintenance rTMS for depression
This study tests whether ongoing rTMS treatments can help people who already improved after an initial round of rTMS for depression. It aims to keep the benefits going and prevent relapse.
New York, New YorkAges 18–80 - NCT06508450Recruiting
Mental health support for minority young adults
This trial tests a program to help racial and ethnic minority young adults engage with mental health services. It aims to improve access and participation in care.
The Bronx, New YorkAges 18–34 - NCT05800925Recruiting
Triage survey to check who can join psychiatry research
This study uses a short questionnaire to figure out who is eligible to join future psychiatry research. It may help people get routed into studies that match their situation and safety needs.
New York, New YorkAges 18 years+ - NCT07716098RecruitingPhase 3
Esketamine nasal spray for treatment-resistant depression
This study tests esketamine nasal spray versus a placebo in adults with depression that has not improved after trying at least two other antidepressants. It aims to see if the spray can help when standard pills have not worked.
New York, New YorkAges 18 years+ - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Buffalo, New YorkAges 10–17 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
New York, New YorkAges 18–75 - NCT05773755Recruiting
Brain stimulation surgery for treatment-resistant depression
This trial studies whether deep brain stimulation (DBS)—a surgically placed brain device—can reduce severe, long-lasting depression that hasn’t responded to many treatments. It may help people whose depression has persisted despite trying multiple antidepressant and other evidence-based therapies.
New York, New YorkAges 25–70 - NCT06213324RecruitingPhase 4
Ketamine's effects on brain circuits in depression
This trial studies how ketamine affects brain circuits in people with depression compared to healthy volunteers. It involves a single infusion of ketamine and brain scans before and after.
New York, New YorkAges 18–65 - NCT06559826RecruitingPhase 2
Ketamine therapy with or without talk for depression
This study compares ketamine alone to ketamine combined with psychotherapy for treating depression. It may help if you have moderate to severe depression and want to see if adding talk therapy improves results.
New York, New YorkAges 18–90 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
New York, New YorkAges 18–75 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Cedarhurst, New YorkAges 18–75 - NCT07745374Recruiting
Deep brain stimulation for bipolar depression
This study tests whether deep brain stimulation (DBS), a surgical treatment that uses electrical pulses to target specific brain areas, is safe and feasible for people with bipolar depression that hasn't improved with other treatments. It may offer a new option for those who have exhausted standard therapies.
New York, New YorkAges 22–70
Depression Disorders trials by city in New York
Where these studies are running in New York
Institutions with a site for the recruiting depression disorders studies listed above.
- Icahn School of Medicine at Mount Sinai · 4 studies
- Bioscience Research · 2 studies
- Draig Clinical Site · 2 studies
- Fieve Clinical Research, Inc · 2 studies
- NYU Langone Health · 2 studies
- UB Department of Psychiatry · 2 studies
- Weill Cornell Medicine · 2 studies
- Adams Clinical Bronx
What taking part in a depression disorders study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Depression Disorders trials in other states
Common questions
- Are there depression disorders clinical trials in New York?
- Yes. We're currently tracking 64 recruiting depression disorders studies with a site in New York, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression disorders study in New York?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in New York to take part?
- Not necessarily. These studies have a site in New York, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression disorders trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression disorders studies open in New York regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.