Clinical trials · Miami, FL
Depression clinical trials in Miami
We’re tracking 51 recruiting depression studies with a site in or near Miami — including Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies near Miami
- NCT06372964RecruitingPhase 3
Lumateperone for pediatric bipolar depression
This study tests a new medication called lumateperone for treating depression in children and teens with bipolar disorder. It aims to see if this drug can help improve mood and daily functioning.
Miami, FloridaAges 10–17 - NCT06963021RecruitingPhase 3
Study of NBI-1065845 for depression that hasn't fully responded to treatment
This trial tests an investigational drug called NBI-1065845 added to your current antidepressant. It is for people with moderate to severe depression or persistent depressive disorder who have not improved enough with oral antidepressants alone.
Miami, FloridaAges 18 years+ - NCT06830044RecruitingPhase 3
Adding an experimental drug for major depression
This trial tests if adding a new medicine called milsaperidone can help people with major depression who haven't gotten enough relief from their current antidepressant. It aims to see if the combination works better than the antidepressant alone.
Miami, FloridaAges 18–65 - NCT06911112RecruitingPhase 3
A new pill for depression when current treatment isn't working well enough
This trial tests an investigational medication (NBI-1065845) added to your current antidepressant to see if it can improve depressive symptoms. It is for people with moderate to severe depression who have not fully responded to their current antidepressant.
Miami, FloridaAges 18 years+ - NCT06941298Recruiting
Cannabis and depression study for teens and young adults
This study looks at how cannabis affects the brain and mood in teens and young adults. It compares people who use cannabis, people with depression who don't use cannabis, and healthy volunteers to understand links between cannabis use and mental health.
Miami, FloridaAges 14–20 - NCT07329673Recruiting
Testing QbMobile app for ADHD-like symptoms
This trial uses an iPhone app called QbMobile to help tell the difference between ADHD and other conditions like autism, depression, bipolar disorder, or anxiety. It may help people who are not currently being treated for these conditions.
Miami, FloridaAges 6–60 - NCT06633016RecruitingPhase 2
ABX-002 for major depression (add-on treatment)
This trial tests a new medication called ABX-002 as an add-on to your current antidepressant. It's for people with moderate to severe depression who haven't gotten enough help from their current antidepressant alone.
Miami, FloridaAges 18–65 - NCT07276997RecruitingPhase 2
Study of Icalcaprant for major depressive disorder
This trial tests an oral medication called icalcaprant for adults with major depressive disorder (MDD). It aims to see if the drug can reduce depression symptoms and what side effects may occur.
Miami, FloridaAges 18–65 - NCT07300969RecruitingPhase 2
Testing DT-101 for adults with depression
This trial tests a new medicine called DT-101 to see if it helps people with depression. It is for adults who have had more than one depressive episode in their life.
Miami, FloridaAges 18–75 - NCT06524830RecruitingPhase 2
Testing VLS-01 film for treatment-resistant depression
This trial tests an experimental film placed inside the cheek (VLS-01) against a placebo to see if it helps people whose depression hasn't improved with standard antidepressants. If you have tried at least two antidepressants without success, this study may be an option for you.
Miami, FloridaAges 18–65 - NCT06922110Enrolling by invitationPhase 3
Long-term study of azetukalner for depression
This study is for people who already completed a previous trial of azetukalner for major depressive disorder. It tests the long-term safety and effects of continuing the medication.
Coral Gables, FloridaAges 18 years+ - NCT06038721Recruiting
Unified Protocol for kids with emotional concerns
This trial tests a program called Unified Protocol for children ages 7–17 who have emotional difficulties like anxiety, depression, trauma, or obsessive-compulsive symptoms. It aims to help kids and their parents learn skills to manage these feelings together.
Coral Gables, FloridaAges 7–17 - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Coral Gables, FloridaAges 18–75 - NCT06057337Recruiting
Families with pride for Hispanic LGBTQ+ teens
This study helps Hispanic LGBTQ+ teens and their families build stronger bonds and pride. It includes family activities and conversations to support your identity and well-being.
Coral Gables, FloridaAges 13–19 - NCT05991713Recruiting
GPS and brain study for healthy volunteers
This study uses a smartphone GPS app and brain scans (fMRI) to understand how daily emotions and movement patterns are connected. It may help researchers learn more about how people's environments affect their feelings.
Coral Gables, FloridaAges 18–50 - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Hialeah, FloridaAges 18–75 - NCT05922878RecruitingPhase 2
ALTO-300 study for moderate to severe depression
This trial tests ALTO-300 as an add-on treatment for people with moderate to severe major depressive disorder (MDD). It aims to see whether ALTO-300 helps improve depression symptoms when you’re already on a stable antidepressant.
Miami Lakes, FloridaAges 18–70 - NCT07412756RecruitingPhase 3
Brenipatide for major depressive disorder
This trial tests a new medication, Brenipatide, to see if it helps people with major depression who are already on a stable treatment. You would need to inject the study drug yourself and complete questionnaires.
Miami Lakes, FloridaAges 18–75 - NCT07196501RecruitingPhase 3
Study of a new add-on treatment for depression maintenance
This trial tests a new medication (NBI-1065845) added to your current antidepressant to see if it helps maintain improvement in depression. It is for people whose depression hasn't fully responded to their current oral antidepressant.
Miami Gardens, FloridaAges 18 years+ - NCT06605105Enrolling by invitationPhase 3
Long-term extension trial of CYB003 for depression
This long-term study is for people who already completed an earlier trial of the experimental drug CYB003 for major depression and who stayed on their regular antidepressant. It looks at the safety and effects of taking CYB003 again over many months.
Hollywood, FloridaAges 18–85 - NCT07284667RecruitingPhase 2
A new medicine for depression that hasn't improved with other treatments
This trial tests a new medicine called ACP-211 in adults with major depression who have not gotten enough relief from at least two previous antidepressants. The goal is to see if it can help when other treatments have not worked well.
Hollywood, FloridaAges 18–65 - NCT07048574Recruiting
Mood and behavior in children with cystic fibrosis
This study looks at mood and behavior in children with cystic fibrosis (CF) under 12. By following children over time, researchers hope to better understand and help with depression, anxiety, and behavior challenges that may come up.
Hollywood, FloridaAges 1.5 years–11 years - NCT06786624RecruitingPhase 3
Testing a new drug for depression that hasn't fully responded to treatment
This trial tests a new medication called NBI-1065845 added to your current antidepressant for people with depression that hasn't fully responded to treatment. It aims to see if this combination can better improve your symptoms.
Hollywood, FloridaAges 18 years+ - NCT06652503Recruiting
Student wellness and emotional growth program
This trial tests a program called SWAG-R designed to help NSU undergraduate students build resilience and manage emotions. It may be a good fit if you are not currently in therapy or dealing with serious mental health issues.
Fort Lauderdale, FloridaAges 18 years+
Hear when a new Depression trial opens near Miami, FL
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Depression trials in other cities
Where these studies are running near Miami
Institutions with a site for the recruiting depression studies listed above.
- Neurocrine Clinical Site · 3 studies
- CenExel · 2 studies
- Draig Clinical Site · 2 studies
- PharmaSouth Research, LLC · 2 studies
- UM Sylvester Comprehensive Cancer Center at Coral Gables · 2 studies
- Advanced Research Institute of Miami
- AP Medical Research
- Autobahn
What taking part in a depression study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Looking wider? See all recruiting depression studies in Florida.
Common questions
- Are there depression clinical trials near Miami?
- Yes. We're currently tracking 51 recruiting depression studies with a site near Miami, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a depression study near Miami?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Miami to take part?
- Not necessarily. These studies have a site near Miami, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a depression trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New depression studies open near Miami regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.