Clinical trials
Depressive and Anxiety Disorders clinical trials
Below are recruiting depressive and anxiety disorders clinical trials, each written for real people, not researchers. We’re tracking 435 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06032377Recruiting
Online therapy for sleep and brain health in older adults
This study tests an online talk therapy program (CBT) to help older adults with both sleep troubles and mild memory or thinking concerns. It's done from home, and aims to improve sleep and brain health.
Ottawa, OntarioAges 60–99 - NCT05897021Recruiting
Writing exercises to ease stress for sexual minority veterans
This study tests whether guided “expressive writing” helps reduce distress linked to sexuality-based stress. It targets veterans who have meaningful anxiety or depression symptoms and ongoing stress related to their sexual identity.
Boston, MassachusettsAges 18 years+ - NCT05897619Recruiting
CBT skills app for pregnancy and postpartum stress and coping
This study tests whether a new phone app that teaches “cognitive behavioral therapy” (CBT) skills is helpful and easy to use for people who are pregnant or recently gave birth. It also checks safety and whether participants feel the app is acceptable to use over time.
New York, New YorkAges 18 years+ - NCT05802004Recruiting
Sound stimulation to improve sleep and emotions in young adults
This study tests whether gentle sound stimulation during sleep can improve sleep and how you think and feel in daily life when you have anxiety or depression symptoms. You’ll also do sleep testing in a lab and complete questionnaires to measure changes.
Pittsburgh, PennsylvaniaAges 18–25 - NCT05447689Recruiting
Group mind-body skills for anxious graduate students
This trial offers a weekly group program teaching mind-body skills to help reduce anxiety. It’s for graduate students who screen as having moderate or higher anxiety and can attend meetings regularly.
White Plains, New YorkAges 18 years+ - NCT05371470Enrolling by invitation
Smartphone voice analysis to track depression and anxiety in rehab
This study tests whether a smartphone app that listens to your voice can detect changes in depression and anxiety while you’re in cardiac rehabilitation. If it works, it may help people get timely support during recovery.
Rochester, MinnesotaAges 18 years+ - NCT05453513Recruiting
Study how depression and cannabis affect the brain in young adults with HIV
This study looks at brain activity to understand how depression and cannabis use may be linked in young adults living with HIV. It mainly involves questionnaires, mental health screening, and brain scans, which may help researchers better understand risk factors and brain “underpinnings.”
Miami, FloridaAges 18–59 - NCT06682689Recruiting
Nerve stimulation study for new mothers' mental health
This study tests whether a gentle nerve stimulation device (tVNS) worn on the ear can help new mothers feel better emotionally after childbirth. It is for women whose babies had normal organ scans and who do not have certain medical conditions or current mood disorders.
Tübingen, Baden-WurttembergAges 18 years+ - NCT07138664Recruiting
Mental health program for teens in Malaysia
This trial tests a program to help young teenagers in Malaysia who are experiencing anxiety or depression. The program aims to improve mental health and well-being.
Kota Kinabalu, SabahAges 12–14 - NCT06567210Recruiting
Insomnia treatment and emotional memory regulation for mental health
This study tests whether treating insomnia can help regulate emotional memories overnight, which may reduce the risk of developing or worsening mental health conditions. You may be eligible if you have both insomnia and some anxiety symptoms.
Macquarie Park, New South WalesAges 18–45 - NCT07412132RecruitingPhase 3
Testing lacosamide for hard-to-treat bipolar depression
This study tests if a medication called lacosamide can help people with bipolar depression that has not improved with at least two other treatments. It's for those with moderate to severe depression in bipolar I or II.
São Paulo, São PauloAges 18–65 - NCT07160673Recruiting
Tech-based caregiver break for homebound older adults
This study is testing if a virtual reality (VR) headset or video interaction can give caregivers a short break while the older adult they care for stays safe at home. It aims to reduce caregiver stress and improve well-being for both of you.
Hong Kong, 香港島Ages 18 years+ - NCT05323864Recruiting
Altitude exposure study for anxiety and low mood
This trial looks at what happens to people with anxiety and depressive symptoms after going to high altitude with low oxygen. It may help researchers understand whether altitude affects these symptoms and how it might be managed.
Innsbruck, TyrolAges 18–65 - NCT05384158Recruiting
Testing a computer game for low mood, low pleasure, or anxiety
This trial looks at how a computer-based task performs when someone is dealing with depression-like symptoms, such as low mood, low interest/pleasure, or anxiety that affects daily functioning. You might find it helpful if you fit their symptom and safety requirements and are comfortable with computer tasks and (for some parts) MRI scanning.
Roanoke, VirginiaAges 25–50 - NCT07149428Recruiting
Deep study of smell loss causes using brain scans
This study uses brain imaging and electrical recordings to understand the brain's role in smell loss from any cause—like COVID, sinus problems, or chemotherapy. You may be eligible if you have any degree of smell loss lasting under a year.
Bethesda, MarylandAges 18–99 - NCT07409792Enrolling by invitation
Ear seed therapy for anxiety, sleep, and IVF success
This trial tests if sticking tiny seeds on ear points (auricular therapy) can help women going through IVF feel less anxious, sleep better, and possibly improve their chances of pregnancy. It is for women with infertility who are about to have a frozen embryo transfer and have some anxiety or sleep problems.
Hangzhou, ZhejiangAges 20–45 - NCT07079930RecruitingPhase 1
Study on psilocybin and D-serine safety in healthy volunteers
This trial tests whether a combination of psilocybin and D-serine is safe and affects mood and thinking. It's for healthy people who want to help research on psychedelics.
JerusalemAges 25–60 - NCT07558785Enrolling by invitation
Testing speech and memory checks at home for early thinking problems
This study uses a video-based system at home to check your speech and memory, helping doctors spot thinking problems early using artificial intelligence. The goal is to see if this simple, at-home test can reliably catch early memory and thinking changes.
PilsenAges 40 years+ - NCT07022925Recruiting
Wearable device for tracking hot flushes in perimenopause
This study will test if a wearable device can accurately track symptoms like hot flushes and night sweats in women going through perimenopause. If you are between 35 and 55 and experiencing these symptoms, your participation could help improve future symptom monitoring.
London, OntarioAges 35–55 - NCT07765355Recruiting
Virtual nature for anxiety in hospitalized older adults
This trial tests whether watching virtual nature scenes or guided imagery can help reduce anxiety and improve well-being in older adults while they are in the hospital. It may offer a calming, drug-free way to support your mental health during a hospital stay.
BudapestAges 65 years+ - NCT05895006Recruiting
Study brain responses in PTSD using stimulation and brain scans
This study looks at how anxiety and stress show up in the brain in people with PTSD, using brain stimulation and brain scanning. If you’re eligible, it may help researchers understand your symptoms and how they relate to brain activity.
Houston, TexasAges 18–50 - NCT07483515Recruiting
Bonding before birth: an app for first-time parents
This trial tests a mobile health app for first-time expectant couples to strengthen bonding during pregnancy. It may help reduce stress and improve emotional connection.
SingaporeAges 21–75 - NCT02543983RecruitingPhase 2
Brain scan and ketamine study for suicidal thoughts
This trial studies how ketamine affects the brain in people dealing with suicidal thoughts or an active suicide crisis. It uses questionnaires, consent testing, and brain imaging to look for biological changes that may relate to symptom improvement.
Bethesda, MarylandAges 18–70 - NCT07079839Recruiting
Anxiety and stress study for adults with PTSD
This study looks at how the brain processes anxiety and stress in people with PTSD and healthy adults. It uses brain scans and mild electrical stimulation to understand these responses better.
Houston, TexasAges 18–50
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Common questions
- Are there clinical trials for depressive and anxiety disorders?
- Yes. Clin2 currently lists 435 recruiting depressive and anxiety disorders studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive and anxiety disorders trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive and anxiety disorders trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.