Clinical trials
Depressive Disorder clinical trials
Below are recruiting depressive disorder clinical trials, each written for real people, not researchers. We’re tracking 669 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07207239Enrolling by invitation
Brain stimulation for treatment-resistant depression
This trial is testing a type of brain stimulation therapy called theta-burst rTMS to see if it helps with depression that hasn't improved with standard treatments. It also uses brain scans to predict who might respond best.
Budapest, Pest CountyAges 18 years+ - NCT06897670Recruiting
Brain blood flow patterns in mood and memory disorders
This study uses a headband with light sensors (fNIRS) to measure blood flow in the brain while you do thinking tasks. It aims to understand differences in brain activity for people with depression, bipolar disorder, or mild memory loss.
Rochester, MinnesotaAges 18 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT06004115RecruitingPhase 4
Brain scanning study for depression and anxiety
This study uses brain scans (fMRI) to understand how people with both depression and anxiety respond to threat. If you have either or both conditions, participating could help researchers find better treatments.
Tulsa, OklahomaAges 18–65 - NCT06488573Recruiting
Nutrition program to improve heart health in bipolar disorder
This study tests if a nutrition program can help people with bipolar disorder improve their heart health. It is for adults aged 18 to 60 with bipolar I or II who are already on medication and are at moderate or high risk for heart problems.
São Paulo, São PauloAges 18–60 - NCT05616559Recruiting
Precision-guided treatment for single-episode depression
This study tests a more personalized approach to treating depression in people who have had one episode. It uses questionnaires and brain scans (for some participants) to help decide which treatment approach may work best.
CopenhagenAges 18–65 - NCT05583747Recruiting
Brain stimulation therapy with guidance for treatment-resistant depression
This study tests a type of brain stimulation (guided iTBS) to improve depression when standard antidepressant treatments haven’t helped. It also checks that the treatment is safe for people who can meet the study and scan safety requirements.
Toronto, OntarioAges 18–65 - NCT07834684Recruiting
Singula health survey for routine primary care visits
This study tests a new survey during a regular doctor's visit to see if it helps improve care. If you join, you'll answer questions on your own device.
Brentwood, New YorkAges 18 years+ - NCT06467474Recruiting
Group Education Program for Depression
This trial tests a group education program (psychoeducation) for people with moderate to severe major depression. It’s designed to help you learn skills to manage your depression alongside medication.
São PauloAges 18–59 - NCT07810023Enrolling by invitation
Ketamine shot for suicidal distress in the emergency room
This study tests whether a single ketamine injection can quickly reduce suicidal thoughts in people waiting to be admitted to the psychiatric unit. Ketamine is a fast-acting medication that may help calm the mind during a crisis.
Evanston, IllinoisAges 18 years+ - NCT07779707Recruiting
Healthy groceries for people with depression and food needs
This study gives free, healthy groceries made to match your health needs and offers support to help improve your mood and reduce stress. It aims to see if getting nutritious food can help people with depression feel better.
Worcester, MassachusettsAges 18 years+ - NCT07753473Recruiting
Brain stimulation for young adults with depressive symptoms
This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to see if it can improve how the brain and heart work together in people aged 18 to 30 who have mild depressive symptoms. The goal is to understand if this treatment could help with mood regulation.
Xi'an, ShaanxiAges 18–30 - NCT07694076Recruiting
Real-time brain feedback for depression
This trial uses a powerful MRI scanner to give you real-time feedback on brain activity linked to depression. You will learn to regulate that activity, which may reduce symptoms.
OxfordAges 18–65 - NCT07685925Enrolling by invitation
Health study for 2026 medical interns
This study tracks medical interns during their first year using a smartphone app. It aims to understand how internship affects health.
Ann Arbor, MichiganAges 18 years+ - NCT05813093Recruiting
Brain stimulation and brain scans for hard-to-treat depression
This trial tests an alternating combination of brain stimulation and brain imaging to see if it helps people with depression that hasn’t improved with usual treatments. The goal is to find a safer, more effective approach for people whose depression has been very difficult to treat.
Toronto, OntarioAges 20–65 - NCT07639606Recruiting
Mobile therapy app for mood after recent stroke
This study tests whether using a smartphone or tablet app for cognitive behavioral therapy (a type of talk therapy you do on your device) can help with anxiety and depression in the first month after a stroke. The goal is to see if this convenient, at-home approach improves how you feel during early recovery.
New York, New YorkAges 18–79 - NCT07642882Recruiting
Brain Stimulation for Fibromyalgia Pain Relief
This study tests whether a non-invasive brain stimulation treatment (rTMS) can reduce chronic pain in fibromyalgia patients. The treatment uses magnetic pulses to stimulate specific areas of the brain and may help relieve widespread pain.
Boulogne-Billancourt, Île-de-France RegionAges 18–80 - NCT07645157RecruitingPhase 2
Sertraline and Probiotics for Teen Depression
This study tests whether combining an antidepressant medication (sertraline) with special bacteria supplements (probiotics) can help treat depression in teenagers ages 12–18. Researchers believe the probiotics may help the medication work better by improving gut health.
Chongqing, YuzhongAges 12–18 - NCT07636694Recruiting
Brain Stimulation and Thinking Pattern Training for Depression
This study tests whether combining two treatments—magnetic brain stimulation (rTMS) and a computer program that helps retrain thought patterns—can reduce depression symptoms. You'll receive these treatments either together or one after the other to see which approach works best.
Quarry Bay, Hong Kong IslandAges Any age - NCT06038409Recruiting
Ketamine therapy for chronic conditions
This trial tests if ketamine can help people with long-term health issues. It aims to find new treatments for chronic conditions that haven't responded well to other therapies.
Helena, MontanaAges 18 years+ - NCT07610473RecruitingPhase 2
Testing DT-101 as an add-on for depression
This trial tests if a new medication, DT-101, can help when added to your current depression treatment. It's for adults with recurrent depression who may need extra support.
Phoenix, ArizonaAges 18–75 - NCT07539805RecruitingPhase 2
Sertraline Plus Probiotic for Teen Depression
This study tests whether combining sertraline (an antidepressant) with a specific probiotic called Lactobacillus crispatus can safely and effectively treat depression in teenagers. The probiotic may help by improving gut health, which researchers believe could support mental health.
Longgang, Chongqing MunicipalityAges 12–18 - NCT07534475Recruiting
Tourniquet Type for Monitoring Brain Activity During ECT
This study compares two types of arm tourniquets (blood-pressure cuffs) used during electroconvulsive therapy (ECT) to help doctors monitor seizure activity more accurately. ECT is a treatment for severe depression and other psychiatric conditions, and tourniquets help track how well the treatment is working.
IstanbulAges 18–65 - NCT07510880Recruiting
Home brain stimulation for major depression
This trial tests a home-based brain stimulation device (tDCS) to treat depression. You would use a headset daily for a few weeks, and the study team will check in to make sure it's working safely and effectively.
L'Hospitalet de Llobregat, BarcelonaAges 18–65
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Common questions
- Are there clinical trials for depressive disorder?
- Yes. Clin2 currently lists 669 recruiting depressive disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a depressive disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a depressive disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.