Clinical trials
Digestive System Cancer clinical trials
Below are recruiting digestive system cancer clinical trials, each written for real people, not researchers. We’re tracking 62 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04475640Recruiting
Genetic testing study for cancer patients in different ethnic groups
This study looks at cancer-related inherited gene changes using blood samples. It may help patients and doctors understand cancer risk and guide treatment planning, especially across different ethnic communities.
Scottsdale, ArizonaAges 18 years+ - NCT06104241RecruitingEarly Phase 1
Cell therapy for advanced digestive cancers
This trial tests a new cell therapy called BGT007 for people with advanced cancers of the digestive system (esophagus, stomach, pancreas, or colon) that have not responded to standard treatments. The therapy uses your own immune cells, modified to target a protein on your cancer cells.
Xuzhou, JangSuAges 18–70 - NCT05624099RecruitingPhase 2
Camrelizumab plus chemoradiotherapy for advanced esophageal cancer
This study tests whether adding camrelizumab (an immune treatment) to standard chemoradiotherapy can control advanced esophageal squamous cell cancer. It is meant for people who have not had any prior whole-course cancer medicines for this cancer stage.
FuzhouAges 18–75 - NCT06475352RecruitingPhase 2
Tailoring chemo dose for GI cancer patients low in a liver enzyme
This trial tests whether adjusting the dose of chemotherapy drugs (5-FU or capecitabine plus oxaliplatin) based on a liver enzyme test can improve safety and effectiveness for people with gastrointestinal cancer who are starting this type of chemo for the first time.
AmiensAges 18 years+ - NCT04666727Recruiting
Diet and gut microbiome study during screening colonoscopy
This study looks at how a person’s diet (vegetarian vs. omnivorous) affects the germs in the gut and related stool and tissue samples. You may be able to join if you’re getting a screening colonoscopy and meet lifestyle and medication requirements.
Houston, TexasAges 45 years+ - NCT07456852RecruitingPhase 1/Phase 2
Can vasodilators help with chemo side effects in GI cancer?
This trial tests two drugs (isosorbide mononitrate and diltiazem) to see if they can prevent blood vessel damage caused by chemotherapy drugs like 5-FU or capecitabine in people with gastrointestinal cancers.
Rochester, MinnesotaAges 18 years+ - NCT05441163Recruiting
Nutrition and exercise program for frail advanced digestive cancer patients
This study tests whether a personalized plan for food (nutrition) and safe, adapted exercise can improve care in frail people with advanced digestive cancers. You may be more likely to feel stronger and better supported during first-line cancer treatment.
Tours, Institut CurieAges 18 years+ - NCT00991094Recruiting
Study follow-up after proton radiation treatment
This study collects information about both short-term and long-term side effects in people who receive proton radiation. It may help doctors better understand what happens to normal tissues over time and improve follow-up care.
Houston, TexasAges 18 years+ - NCT06626269Recruiting
Biomarkers for immunotherapy in digestive and gynecological cancers
This study looks for new markers in the blood or tumor that could predict how well immunotherapies work for advanced digestive and gynecological cancers. It includes people getting immunotherapy, chemotherapy, or targeted therapy, and also those with certain liver or abdominal metastases that can be surgically removed after chemo.
BesançonAges 18 years+ - NCT06817161RecruitingPhase 3
Nerve stimulation for quality of life during ovarian cancer treatment
This trial tests if a gentle nerve stimulation device on the ear can improve quality of life for people with ovarian cancer who are starting their first chemotherapy. It may help manage symptoms like fatigue or feeling sick.
CaenAges 18 years+ - NCT06500455RecruitingPhase 3
Standard vs longer radiation for brain metastases
This trial compares the usual short course of radiation therapy (one session) to a longer course (up to 5 sessions) for people with cancer that has spread to the brain. The goal is to see if the longer course works better and causes fewer side effects.
Tucson, ArizonaAges 18 years+ - NCT07215624Recruiting
Survey on blood clot prevention after cancer surgery
This study surveys surgeons and surgical advanced practice providers about how they prevent blood clots (deep vein thrombosis) in patients after cancer surgery. It aims to understand current practices and improve future care.
Fort Smith, ArkansasAges 18 years+ - NCT04268121RecruitingPhase 2
Neoadjuvant chemotherapy before surgery for certain digestive neuroendocrine cancers
This study looks at whether chemotherapy given before surgery improves how long patients live without the cancer coming back. It’s aimed at people with localized, poorly differentiated digestive neuroendocrine carcinoma with a higher growth rate marker.
AmiensAges 18 years+ - NCT04221893Recruiting
Radiation therapy for metastatic gastrointestinal cancers
This trial tests whether adding radiation therapy to your current immunotherapy can help control cancer that has spread in the digestive system. It aims to improve symptoms and possibly slow the cancer's growth.
San Francisco, CaliforniaAges 18 years+ - NCT07263620Recruiting
Gut bacteria and cancer treatment before surgery
This study looks at the bacteria in your gut to see if they can predict how well chemotherapy or radiation works before surgery for certain cancers. If you have pancreatic, stomach, colon, or esophageal cancer that has spread nearby (but not to distant organs), you may be able to join.
TianjinAges Any age - NCT07061080RecruitingPhase 2
Tarlatamab for advanced digestive neuroendocrine cancer
This trial tests a new drug called Tarlatamab for people with advanced neuroendocrine carcinoma (a rare and aggressive cancer) of the digestive system that has stopped responding to prior chemotherapy. The drug targets a protein called DLL3 found on some tumors, and researchers hope it can shrink or slow tumor growth.
Brest, BrestAges 18 years+ - NCT06349044Recruiting
Radiation and immunotherapy with or without probiotics for advanced digestive cancers
This trial tests if adding a probiotic (Lactobacillus rhamnosus M9) to standard radiation and immunotherapy can help people with advanced digestive system cancers. It aims to see if the combination is more effective and safer than the standard approach alone.
Hangzhou, ZhejiangAges 18–75 - NCT01696734RecruitingPhase 3
Domperidone for difficult stomach and reflux problems
This trial studies whether domperidone can help people whose stomach or reflux symptoms did not improve with usual treatments. It focuses on symptoms like slow stomach emptying, hard-to-control acid reflux, or severe indigestion.
Houston, TexasAges 16 years+ - NCT06202066RecruitingPhase 2
Temozolomide plus Survivin Vaccine for Growing Neuroendocrine Tumors
This trial tests a combination of a chemotherapy drug (temozolomide) and a vaccine (SurVaxM) that targets a protein called survivin found in some neuroendocrine tumors. It is for patients whose tumors have grown after at least one prior treatment, with the goal of slowing or stopping further growth.
Buffalo, New YorkAges 18 years+ - NCT06380309RecruitingEarly Phase 1
Study of experimental drug IDOV-SAFE for advanced digestive cancers
This trial tests an investigational drug for people with advanced digestive system cancers (like colorectal, stomach, or liver cancer) that have stopped responding to standard treatments. The goal is to see if the drug is safe and helps control the cancer.
BeijingAges 18–75 - NCT07283939Recruiting
Testing a tool to adjust chemo doses and reduce treatment delays
This trial tests a computer algorithm called PAGODA that helps doctors adjust chemotherapy doses for people with gastrointestinal cancers. The goal is to prevent unplanned treatment delays while keeping the treatment effective.
Fairbanks, AlaskaAges 18 years+ - NCT03303495RecruitingPhase 3
Second-line chemo with or without bevacizumab for colon cancer
This Phase 3 study compares two treatment plans for people with metastatic colorectal cancer that got worse or caused side effects after first chemotherapy. It looks at whether adding bevacizumab (a medicine that targets blood vessels feeding tumors) improves outcomes versus using a different chemotherapy approach.
Guangzhou, GuangdongAges 18 years+ - NCT06271538RecruitingPhase 4
Skal Pro Powder for IBS symptoms
This study tests if Skal Pro Powder, a probiotic, can help relieve symptoms of Irritable Bowel Syndrome (IBS). It is for adults with any type of IBS who haven't used certain other treatments recently.
Kubang Kerian, KelantanAges 18 years+ - NCT07421596Recruiting
Dietary supplement study for gut and digestive health
This trial tests whether a dietary supplement system can improve gut and digestive health over 8 weeks. You may be eligible if you have digestive symptoms like bloating, stomach pain, or diarrhea.
San Francisco, CaliforniaAges 18–80
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Common questions
- Are there clinical trials for digestive system cancer?
- Yes. Clin2 currently lists 62 recruiting digestive system cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a digestive system cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a digestive system cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.