Clinical trials
Disease clinical trials
Below are recruiting disease clinical trials, each written for real people, not researchers. We’re tracking 9,578 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04774536RecruitingPhase 1/Phase 2
CRISPR gene-edited bone marrow transplant for severe sickle cell
This Phase 1/2 study tests a CRISPR-edited bone marrow (stem cell) transplant to treat severe sickle cell disease. It aims to reduce dangerous sickle-related complications by changing the patient’s stem cells before transplant.
Los Angeles, CaliforniaAges 12–35 - NCT04774159RecruitingPhase 3
Low-dose colchicine to lower risk in leg artery disease
This trial tests whether low-dose colchicine can reduce “residual” risk—future heart and blood-vessel problems—in people with peripheral artery disease (PAD). It targets PAD symptoms and complications like poor blood flow in the legs, even after certain procedures.
New Haven, ConnecticutAges 18 years+ - NCT04775537Recruiting
OssiMend bone graft for lumbar spine fusion surgery
This trial studies whether OssiMend bone graft helps heal a lumbar spine fusion for people whose disc disease has not improved with non-surgical care. It may be an option if you need back surgery due to specific spine wear-and-tear changes.
Encinitas, CaliforniaAges 18 years+ - NCT04779320RecruitingPhase 3
Vedolizumab for teens with moderate to severe Crohn's
This trial tests vedolizumab to treat children and teens with moderate to severe Crohn’s disease when standard treatments haven’t worked or caused side effects. It may help reduce gut inflammation and symptoms and help some patients stay healthier over time.
Phoenix, ArizonaAges 2–17 - NCT04782232Recruiting
Study of a new blood tube for heart pump patients
This registry study checks whether a new venous blood tube used with a heart pump is safe and practical for people whose right heart is failing and who may need a heart transplant. If you qualify, your care team would monitor how the device works over time.
MunichAges Any age - NCT04784364Recruiting
Study of immune treatments at Mount Sinai
This study follows people who are receiving immune-related medications (called biologics or immune modulators) at Mount Sinai. It aims to better understand how these treatments affect the immune system and health over time, which may help improve future care.
New York, New YorkAges 12 years+ - NCT04800484Recruiting
Test how different AFO heel height and stiffness affect walking
This study looks at how changing the heel height and stiffness of an AFO (a brace you wear on your lower leg/foot) changes your walking pattern. The goal is to learn which brace settings may improve comfort and walking.
Iowa City, IowaAges 18–70 - NCT04800588Recruiting
Computer tests to study early Alzheimer’s changes
This study uses computer and touch-screen tasks to measure thinking changes in people who may be in the early, symptom-free stage of Alzheimer’s disease. It aims to understand how these brain-related changes show up on testing, which could help future detection or tracking.
Berkeley, CaliforniaAges 18–89 - NCT04804202Recruiting
Virtual cycling program for people with Parkinson disease
This study tests whether a virtual, guided stationary bike exercise program is safe and helpful for people with Parkinson disease. It may help improve movement and fitness by letting you ride at home or in a controlled setting while using visual and audio guidance.
Newark, New JerseyAges 45–75 - NCT04803916Recruiting
Balloon dilation study for Crohn’s bowel strictures
This study looks at inflammation just before a narrowed section of the bowel in people with Crohn’s disease, using planned endoscopic balloon dilation. It may help doctors better understand what drives narrowing and inflammation so treatment can be timed and chosen more effectively.
JerusalemAges Any age - NCT04806282Recruiting
Study to track hearing instability and find helpful targets
This study follows adults with hearing instability to better understand what causes it, measure it in new ways, and look for potential treatment targets. If you qualify, you may get hearing and balance-related testing (including scans) over a period of time.
Bethesda, MarylandAges 18–80 - NCT04807868Recruiting
Liver fat registry for adults with or at risk for fatty liver
This study builds a research registry (and optional test results follow-up) for adults who either need a routine liver biopsy or may have fatty liver risk based on body weight and other health history. It helps researchers learn more about non-alcoholic fatty liver disease (fatty liver not caused by alcohol) and how it may progress.
Orlando, FloridaAges 18 years+ - NCT04808596Recruiting
Pulmonary hypertension registry and blood sample study
This study builds a registry and collection system for people with pulmonary hypertension, confirmed by a specific heart test. By joining, you help researchers learn more about the condition and may support future studies.
Kansas City, KansasAges 18 years+ - NCT04817072Recruiting
Studying mood changes in inflammatory arthritis patients on biologics
This study looks at how mood disorders (like depression or anxiety) affect people with chronic inflammatory joint diseases when they use biologic medicines. It may help doctors understand which patients are at higher mood-risk and how to monitor them.
BesançonAges 18–80 - NCT04843371Recruiting
Using wearable data to predict heart pump strength
This trial tests whether a wearable device (Biostrap) can help predict how strongly your heart pumps, using echocardiogram (heart ultrasound) results. It may help doctors better estimate heart function from simpler measurements.
New Orleans, LouisianaAges 18–120 - NCT04844060Recruiting
Study collecting spinal fluid from patients needing a lumbar puncture
This study collects cerebrospinal fluid (the fluid around the brain and spinal cord) during a lumbar puncture. It aims to improve how doctors use this information for accurate diagnosis in patients who need the procedure.
StrasbourgAges Any age - NCT04844944Recruiting
Heart registry for adults with heart failure, CAD, or atrial fibrillation
This is a hospital-based study that collects standardized information about adults with specific heart conditions—heart failure, coronary artery disease, or atrial fibrillation. It may help doctors and researchers better understand these diseases and improve future care.
BerlinAges 18 years+ - NCT04848844Recruiting
Congenital heart disease transplant registry study for adults
This study collects and shares anonymous information about adults being considered for a heart transplant because of a congenital (from birth) heart problem or an inherited heart muscle condition. The goal is to better understand these patients and support research that may improve care.
HamburgAges 18 years+ - NCT04848077Recruiting
Smartphone exercise program for early Parkinson’s patients
This trial tests whether a motivating phone-based exercise plan can help people with early-stage Parkinson’s move more safely and consistently. You may qualify if you can walk on your own, understand Dutch, and are fairly inactive right now.
Nijmegen, GelderlandAges 18 years+ - NCT04848623Recruiting
Listening test to find voice clues of long-term health
This study is looking for “vocal biomarkers,” meaning voice patterns that could hint at how well people are doing with chronic (long-term) health conditions. Your participation would involve providing voice samples so researchers can see what voice features relate to health.
LuxembourgAges 15 years+ - NCT04849806Recruiting
Testing whether heart nerve signals predict COPD symptoms
This study looks at “sympathetic nerve activity” (signals from the nervous system that affect the heart) in adults with chronic obstructive pulmonary disease (COPD). The goal is to see whether these measurements can help predict what happens to people with COPD.
AachenAges 18 years+ - NCT04850053Recruiting
Using brain-related “seeds” to help diagnose Alzheimer’s disease
This study looks for specific markers (“seeds”) that may help doctors diagnose Alzheimer’s disease and distinguish it from other memory or thinking conditions. If you are in the right age range and can complete memory testing and provide a sample, you may help validate a diagnostic approach.
Beijing, Beijing MunicipalityAges 55–75 - NCT04858412Recruiting
Amino acid supplement to help people with COVID-19 and alcohol liver disease
This study tests whether an HMB-enriched amino acid supplement can improve outcomes in adults who have COVID-19 pneumonia, especially those with alcohol-related liver disease. The trial compares results in people with alcohol liver disease versus those without, to see if the supplement helps during recovery.
Cleveland, OhioAges 21 years+ - NCT04867408Recruiting
Using bowel scope images to improve inflammatory bowel disease training
This study uses pictures taken during routine bowel scope (endoscopy) to build and test a computer system for training and research in inflammatory bowel disease. It may help doctors and trainees interpret scope images more consistently over time.
Hull, East YorkshireAges 16–99
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Common questions
- Are there clinical trials for disease?
- Yes. Clin2 currently lists 9,578 recruiting disease studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a disease trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a disease trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.