Clinical trials
Distress, Emotional clinical trials
Below are recruiting distress, emotional clinical trials, each written for real people, not researchers. We’re tracking 41 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05712057Recruiting
Brain stimulation vs therapy for emotion regulation problems
This trial compares a type of brain stimulation (rTMS) to therapy to help people better manage strong emotions. You may be eligible if you have ongoing difficulties with emotion control and meet specific mood, anxiety, or related symptom criteria.
Durham, North CarolinaAges 18–55 - NCT05779761Recruiting
Brief coping exercises for high distress and worry
This study tests brief coping interventions to help people who feel very worried, stuck in negative thoughts, or overly self-critical. You would likely complete short activities using your smartphone and internet while the study checks how your distress changes over time.
New York, New YorkAges 18–65 - NCT07280481Recruiting
Mindfulness for emotional distress
This trial tests a weekly mindfulness program to help people with anxiety or depression. It aims to see if learning mindfulness can improve your emotional health.
BeijingAges 18 years+ - NCT07692269Recruiting
Mindfulness for emotional distress study
This study tests whether mindfulness can help reduce emotional distress. You will practice mindfulness and have your brain activity measured with EEG, a safe and painless way to record brainwaves.
Beijing, Beijing MunicipalityAges 18–50 - NCT07100951Recruiting
Comparing two couples therapies for relationship distress
This study compares two types of couples therapy to see which is better at reducing relationship distress. If you and your partner are feeling unhappy or struggling, and either of you also has symptoms of depression or anxiety, this trial may offer free professional help.
IstanbulAges 24–65 - NCT07021352Recruiting
Ear acupuncture for emotional distress in military with PTSD
This trial tests whether ear acupuncture can help active-duty service members and veterans who have emotional distress related to PTSD. You will also receive mindfulness therapy as part of the study.
Fairfield, CaliforniaAges 18–65 - NCT07478393Recruiting
Emotion regulation therapy for worry and self-criticism
This trial tests a therapy that helps people manage emotions like worry and self-criticism. It takes place online, so you can join from home in New York.
New York, New YorkAges 18–65 - NCT05783401Recruiting
Analyzing your voice to spot frailty and distress
This study checks whether analyzing how you speak can help measure frailty (overall vulnerability) and distress (emotional stress) in people with active cancer. It may help clinicians track symptoms in a simple, noninvasive way using short voice recordings.
BaselAges 18 years+ - NCT06570603Recruiting
Study for people struggling with distress
This trial tests a program designed to help people who struggle with intense distress, anxiety, or depression. If you have a smartphone and find it hard to cope with emotional pain or stress, this study may teach you new skills to feel better.
Fayetteville, ArkansasAges 18 years+ - NCT07209306Recruiting
Psychological help for migrants in Italy: The ADVANCE trial
This trial tests two WHO-designed psychological programs (called SH+ and DWM) to help migrants in Italy cope with stress, anxiety, and depression. You will be randomly assigned to one of the programs to see if they improve your mental health and well-being.
Verona, ItalyAges 18 years+ - NCT06888141Recruiting
Stress management program for college students
This trial tests a stress management program designed for college students. It aims to help you learn ways to handle stress better.
Boise, IdahoAges 18 years+ - NCT05626374Enrolling by invitation
Remote check-in tool to reduce dropout in training
This study tests whether adding a remote, self-report tool for distress (how overwhelmed or unwell someone feels) improves how many people complete a vocational training program. It’s meant to support people using the usual case management, but with extra remote check-ins.
Barrie, OntarioAges 18–49 - NCT06651736Recruiting
Low vision rehab for people with inherited eye disease and distress
This study tests a 10-week low vision rehabilitation program for people with inherited retinal diseases who also feel emotionally distressed. The goal is to see if the program improves daily function and emotional well-being.
Ann Arbor, MichiganAges 18 years+ - NCT06435208Recruiting
Gum cleaning for mental health in teeth grinders with gum disease
This study tests whether a deep gum cleaning procedure (subgingival instrumentation) can reduce stress and improve mental health in people who grind their teeth and have gum disease. It aims to see if treating the gums can also help with psychological distress.
Rohtak, HaryanaAges 30–50 - NCT07067619Recruiting
Pain acceptance training for emotional and physical distress
This trial tests a training program to help people accept chronic pain and emotional distress. It looks at how thinking patterns might help or hinder progress.
HaifaAges 18–70 - NCT07458100Recruiting
Step-by-step digital therapy for emotional disorders
This trial tests a digital stepped-care program for people with emotional disorders like depression, anxiety, OCD, PTSD, or eating disorders. It uses online tools to help manage symptoms, and you may access different levels of support based on your needs.
BeijingAges 18–65 - NCT06405373Recruiting
Coping skills program for type 1 diabetes distress
This study tests a program to help adults with type 1 diabetes who feel stressed or overwhelmed by their condition. You'll join virtual group sessions to learn coping skills and track how your distress changes over time.
Chapel Hill, North CarolinaAges 30 years+ - NCT07436845Recruiting
Emotion and treatment for advanced liver cancer
This trial studies if emotional health affects how well targeted therapy and immunotherapy work for people with advanced liver cancer. You will receive chemotherapy directly into the liver along with targeted drugs and immunotherapy.
Guangzhou, GuangdongAges 18 years+ - NCT05383495RecruitingPhase 3
Calming medicine during child laceration repair
This trial tests a calming/anxiety-reducing medicine to see if it helps children feel less scared during stitches for a skin cut. It may help make the repair process easier for children and their caregivers.
London, OntarioAges 2–12 - NCT07290543Recruiting
Online toolkit for cancer distress in rural older adults
This study tests a web-based toolkit designed to help older cancer survivors living in rural areas manage emotional distress and anxiety. It also includes a caregiver who will participate alongside the survivor.
Chicago, IllinoisAges 18 years+ - NCT07018726Recruiting
Help for emotional distress in young-onset dementia and their care-partners
This study tests a program to help people with young-onset dementia (diagnosed before age 65) and their care-partners manage emotional distress. You would join together and learn ways to cope with the challenges of this diagnosis.
Boston, MassachusettsAges 18–65 - NCT06341634Enrolling by invitation
Suicide ideation surveillance in teens
This study follows adolescents aged 11 to 16 to better understand and track suicidal thoughts. It may help improve care for teens with or without these thoughts.
Santiago de Compostela, A CoruñaAges 11–16 - NCT07527052Recruiting
Teen Mental Health and Social Media Study
This study looks at how social media might help teens who have thoughts about hurting themselves feel better. Researchers will ask you questions online and track how you're doing over time.
Miami, FloridaAges 12–17 - NCT04682470Recruiting
Research study following young adults with cancer
This is an observational study that follows young adults with a confirmed cancer diagnosis to learn more about their experience and care. It does not test a new drug, but your information may help improve future cancer treatment and support.
Amsterdam, North HollandAges 18–39
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Distress, Emotional trials by city
Studies with a site in or near these metro areas.
Distress, Emotional trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for distress, emotional?
- Yes. Clin2 currently lists 41 recruiting distress, emotional studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a distress, emotional trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a distress, emotional trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.