Clinical trials · California
Down Syndrome clinical trials in California
We’re tracking 275 recruiting down syndrome studies with a site in California — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT05023005Recruiting
Strain-Counterstrain therapy for piriformis muscle pain
This trial tests a hands-on physical therapy technique called “strain-counterstrain” to reduce pain from the piriformis muscle. It may help people whose pain is coming from that specific muscle rather than the low back.
Loma Linda, CaliforniaAges 18–65 - NCT05107635Recruiting
Registry for people treated with AtriCure for IST or POTS
This registry collects information from people who are getting—or already had—treatment for IST or POTS using an AtriCure device. It helps researchers better understand outcomes and safety in real-world care.
Loma Linda, CaliforniaAges Any age - NCT05184842RecruitingPhase 2
Weekly low-dose decitabine plus venetoclax for MDS or AML
This Phase 2 study tests a gentler weekly combination of two medicines—decitabine and venetoclax—for people with MDS, AML, or MDS/MPN. The goal is to improve blood counts and disease control while reducing side effects compared with more harsh treatments.
Sacramento, CaliforniaAges 18 years+ - NCT05194397RecruitingPhase 2
Exercise plus NR supplement to boost fitness after stem-cell transplant
This trial tests whether a supervised exercise program, plus an NR supplement, can improve fitness in young people who have had an allogeneic (donor) stem-cell transplant for certain blood cancers or bone marrow conditions. It’s meant to help with energy and physical ability while monitoring safety.
Duarte, CaliforniaAges 10–30 - NCT05219110Recruiting
More fluids for children sick with toxin E. coli
This study looks at whether giving extra (hyper) fluids early helps children with a high-risk E. coli stomach infection. The goal is to improve outcomes by supporting the kidneys during the illness.
Sacramento, CaliforniaAges 9 months–21 years - NCT05219617RecruitingPhase 3
Carisbamate for frequent drop seizures in Lennox-Gastaut
This Phase 3 study tests whether carisbamate can reduce drop seizures in people with Lennox-Gastaut syndrome (LGS). It also checks whether the treatment is safe when added to existing seizure medicines.
Palo Alto, CaliforniaAges 4–55 - NCT05386173Recruiting
Tests fetal aortic valve balloon surgery for severe narrowing
This trial studies whether doing a procedure before birth to open a baby’s aortic valve improves outcomes. It compares this approach in a specific group of pregnancies with severe heart flow problems seen on ultrasound.
San Francisco, CaliforniaAges 5 months–7 months - NCT05388006RecruitingPhase 2
Testing three medicines for Richter transformation in CLL/SLL
This Phase 2 trial studies acalabrutinib, venetoclax, and durvalumab together for Richter transformation (a more aggressive lymphoma) that developed from CLL or SLL. The goal is to improve how well treatment works and how long people can respond.
Palo Alto, CaliforniaAges 18 years+ - NCT05412927Recruiting
Heart device follow-up study for high-risk heart patients
This study monitors how well the AngelMed Guardian® System works after it has already been implanted. It focuses on people at higher risk of heart events, including those with diabetes or kidney problems.
Los Angeles, CaliforniaAges 21 years+ - NCT05468437Recruiting
Online nutrition coaching for people with spinal cord injury
This study tests whether telenutrition (nutrition coaching by phone/tablet) can help people with spinal cord injury manage their weight and health. It may be a good fit if you’re mainly using a wheelchair, can use an iPad, and live in California.
San Jose, CaliforniaAges 20 years+ - NCT05575401Recruiting
Track surgery results in kids getting tonsil removal
This trial looks at how well a specific throat surgery technique works in children who are having their tonsils removed (with or without removing adenoids). It may help improve how doctors choose and perform surgery for safer, better recovery.
Murrieta, CaliforniaAges 3–17 - NCT05719935Recruiting
KinematX wrist replacement registry for people with wrist arthritis
This trial is a registry that follows people who get (or already had) a KinematX total wrist replacement. It collects health and recovery information to better understand outcomes for different wrist problems, like arthritis or certain bone alignment issues.
Loma Linda, CaliforniaAges 18–85 - NCT05724173Recruiting
Test of a brain-to-computer device for ALS hand paralysis
This study checks whether a brain-computer interface (a BrainGate2 system) is safe and workable for people with ALS. If you qualify, you may be asked to try the device and complete study tasks to help researchers learn how well it can support communication or control.
Stanford, CaliforniaAges 18–80 - NCT05736146Recruiting
Testing Gulf War illness blood markers for better diagnosis
This study checks blood tests to see whether they can help confirm Gulf War illness. If you qualify as having Gulf War illness (or are a similar Gulf War veteran without it), your blood and health information may be used to validate these marker tests.
Palo Alto, CaliforniaAges 35 years+ - NCT05737121RecruitingPhase 2
Study drug for bladder pain compared with lidocaine, heparin, or placebo
This Phase 2 trial tests VNX001 to see if it helps people with interstitial cystitis/bladder pain syndrome (IC/BPS) compared with its separate ingredients (lidocaine and heparin) or a placebo (inactive treatment). You may be eligible if you have had IC/BPS for months and recently had a moderate-to-severe bladder pain flare.
Newport Beach, CaliforniaAges 18 years+ - NCT05849662RecruitingPhase 1/Phase 2
Trametinib plus azacitidine for newly diagnosed JMML
This trial studies whether trametinib and azacitidine can control juvenile myelomonocytic leukemia (JMML) soon after diagnosis. It’s designed to test safety and how well the treatment works in children and young adults who meet specific leukemia and genetic criteria.
Los Angeles, CaliforniaAges 1 month–21 years - NCT05918861RecruitingPhase 3
Tested heart-risk drug for people with recent heart-attack genetics
This trial studies whether dalcetrapib can lower future heart and blood-vessel risk in people who recently had an ACS (acute coronary syndrome, often a heart attack or unstable chest pain) and have a specific genetic marker. It may help people like you by targeting a risk pathway related to that genetic background.
Santa Barbara, CaliforniaAges 45 years+ - NCT05922761RecruitingPhase 2
Belumosudil for lung scar prevention or treatment after transplant
This Phase 2 study tests belumosudil to treat or prevent bronchiolitis obliterans (BOS), a lung complication that can happen after a stem cell transplant. If you qualify, you would be checked closely with breathing tests and scans, and watched for safety and whether lung function improves or stays stable.
Stanford, CaliforniaAges 18 years+ - NCT05928052Recruiting
Spinal stimulation to help ARDS patients get off the ventilator
This study tests whether stimulating nerves in the spine can help people with severe lung injury (ARDS) breathe without a ventilator sooner. It may help shorten the time you need a breathing machine in the ICU.
Los Angeles, CaliforniaAges 18 years+ - NCT05953090Recruiting
Vaginal irritation study with device use and long follow-up
This trial studies a treatment for long-lasting vaginal/vulvar irritation caused by conditions like vaginal atrophy or certain skin conditions of the vulva. You would try the study product/device and be followed over time to see how symptoms recover.
Burbank, CaliforniaAges 18 years+ - NCT05960929RecruitingPhase 3
Breathing support for premature babies with lung distress
This Phase 3 trial tests whether InfasurfAero™ (a type of surfactant given as aerosol) works better than a sham treatment in preterm babies with respiratory distress syndrome (RDS). It aims to improve breathing in the first hours of life for babies who need CPAP.
San Diego, CaliforniaAges 7 months–8 months - NCT05978141Recruiting
T-cell lymphoma registry study
This study creates a registry for people with certain T-cell or NK-cell lymphomas. It collects health information and tumor samples to learn more about these diseases and improve future treatments.
San Francisco, CaliforniaAges Any age - NCT06059391RecruitingPhase 2
Vaccine for stem cell donors to prevent CMV
This trial tests whether giving a CMV vaccine to stem cell donors can help protect recipients from CMV infection after transplant. It is for adults with specific blood cancers who are CMV-positive and have a matched related donor.
Duarte, CaliforniaAges 18–75 - NCT06094205Recruiting
BrainGate2 speech study for people with tetraplegia
This study tests a brain-computer interface to help people with severe paralysis communicate by decoding attempted speech or movements. It may offer a new way to interact with devices using only brain signals.
Sacramento, CaliforniaAges 18–80
Down Syndrome trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting down syndrome studies listed above.
- Stanford University · 6 studies
- City of Hope Comprehensive Cancer Center · 3 studies
- University of California, San Francisco · 3 studies
- Loma Linda University Health · 2 studies
- University of California San Diego · 2 studies
- University of California, Davis Medical Center · 2 studies
- University of California, Los Angeles (UCLA) · 2 studies
- Children's Hospital Los Angeles
What taking part in a down syndrome study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Down Syndrome trials in other states
Common questions
- Are there down syndrome clinical trials in California?
- Yes. We're currently tracking 275 recruiting down syndrome studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a down syndrome study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New down syndrome studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.