Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,189 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07757789Recruiting
Platelet changes in antiphospholipid syndrome
This study looks at how platelet counts change over time in people with antiphospholipid syndrome (APS), a condition that can cause blood clots and pregnancy problems. It may help doctors better understand and manage low platelets in APS patients.
Al Khārjah, Kharga OasisAges 18 years+ - NCT07562425Recruiting
Knee Strengthening Exercises for Patellofemoral Pain
This study compares three types of thigh muscle exercises to help reduce knee pain in people with patellofemoral pain syndrome (pain around the kneecap). Researchers want to see which exercise style—holding steady, moving through motion, or lowering slowly—works best for your pain.
Elâzığ, MErkezAges 18–50 - NCT06465641RecruitingPhase 4
Methylphenidate for ADHD symptoms in KBG syndrome
This study tests if the medication methylphenidate (commonly used for ADHD) can help manage attention and behavior problems in people with KBG syndrome. Each person acts as their own test case to see if the drug works for them.
Nijmegen, GelderlandAges 6–20 - NCT07750392Recruiting
Dry needling and gentle laser therapy for recent neck pain
This trial tests two therapies—dry needling (thin needles into muscle knots) and low-level laser/microcurrent (gentle energy) treatment—alone or combined, to relieve acute neck pain from muscle knots (myofascial pain). It aims to reduce pain and improve function for people with recent onset symptoms.
Denpasar, BaliAges 20–45 - NCT04608110RecruitingPhase 1
Novel therapy for myelodysplastic syndrome
This study tests a new combination treatment for people with myelodysplastic syndrome (MDS), a blood disorder. The drug aims to slow the disease and improve blood counts, and might be an option for patients who haven't responded to other treatments.
Bunkyō CityAges 20 years+ - NCT07086755RecruitingPhase 2/Phase 3
Vadadustat treatment for lung injury from infection
This trial tests a pill called vadadustat for people with a serious lung condition called ARDS, which makes it hard to breathe. The drug may reduce inflammation and improve oxygen levels, helping patients recover without needing a breathing tube.
Houston, TexasAges 18 years+ - NCT06660394RecruitingPhase 3
LP352 for Dravet syndrome in children and adults
This study tests a new medicine called LP352 for children and adults with Dravet syndrome. It compares the study drug to a placebo (a pill with no medicine) to see if it helps reduce seizures.
Little Rock, ArkansasAges 2–65 - NCT06776783RecruitingPhase 3
Testing a new surfactant for breathing problems in premature babies
This study tests a new medicine called APC-0101, a type of surfactant, for premature babies with breathing problems (respiratory distress syndrome). It may help their lungs work better and reduce the need for more breathing support.
Little Rock, ArkansasAges 1 hour–1 day - NCT06670222RecruitingPhase 1
Arsenic for low-risk MDS
This study tests an oral form of arsenic in people with low-risk myelodysplastic syndromes (MDS) who need regular red blood cell transfusions and haven't gotten enough benefit from standard treatments. It aims to see if this drug can help reduce transfusion needs.
NiceAges 18 years+ - NCT07753122Recruiting
Hydrogen water for chronic fatigue syndrome
This trial tests whether drinking hydrogen water can help with symptoms of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). If you have ME/CFS, this study might show if hydrogen water is a helpful treatment.
Stony Brook, New YorkAges 18–65 - NCT07752797Recruiting
Ultrasound and nerve tests for carpal tunnel syndrome
This study looks at how ultrasound, nerve tests, and hand function relate to carpal tunnel syndrome. It aims to improve understanding of the condition and may help guide future treatment decisions.
Küçükçekmece, IstanbulAges 18–65 - NCT06899178RecruitingPhase 2
Atomoxetine for genetic obesity due to MC4R changes
This trial tests a medicine called atomoxetine (Strattera) to help people with a specific genetic form of obesity lose weight. It may be an option if you have a change in the MC4R gene and have not used certain other medications recently.
New York, New YorkAges 6 years+ - NCT05092451RecruitingPhase 1/Phase 2
CD70-targeting NK cell therapy for blood cancer relapse
This study tests an immune therapy made from cord blood “NK cells” that are engineered to attack cells with a marker called CD70. It’s given after chemotherapy that reduces your blood and immune system, aiming to treat relapse or refractory (not responding) blood cancers.
Houston, TexasAges 12–80 - NCT06615206Recruiting
First CRISPR RNA therapy for MECP2 duplication syndrome
This trial tests a new CRISPR therapy that edits RNA to treat a rare genetic condition called MECP2 duplication syndrome (MDS). It is for boys aged 2 to 18 who have stable seizures and no other major health problems, with the goal of improving symptoms and safety.
Beijing, Beijing MunicipalityAges 2–18 - NCT05875311Recruiting
Check-in monitoring for people with chronic coronary disease
This trial tests a phone/remote monitoring system to help keep regular follow-ups (“continuity of care”) for people with chronic coronary syndrome after a recent heart event. It may help your care team spot problems earlier and adjust treatment sooner.
ValenciaAges 18–72 - NCT05805566Recruiting
Study of care for long COVID symptoms in adults
This study follows people who enter a specialized care pathway for long COVID (post-COVID syndrome) to better understand symptoms, needs, and outcomes. It may help improve how multidisciplinary care is organized for long COVID over time.
Pierre-BéniteAges 18 years+ - NCT05528900Recruiting
Study of children with acute food-triggered gut reactions
This study follows children (from birth to age 17) who have been diagnosed with acute food protein–induced enterocolitis syndrome (FPIES). Doctors want to better understand this condition after a suspected reaction to food, using either symptom-based diagnosis or a supervised food challenge when needed.
AngersAges Up to 17 years - NCT07747259Recruiting
Core stability and quality of life in active women with polyendocrine metabolic ovarian syndrome
This study compares core stability, body awareness, pelvic health, sleep, and quality of life between physically active women with and without polyendocrine metabolic ovarian syndrome (PMOS). It aims to understand how this condition affects these areas, which may help guide future treatments.
IstanbulAges 18–40 - NCT07749066Recruiting
Laser treatment for hip pain
This study tests a high-intensity laser treatment to reduce hip pain and improve function in people with greater trochanteric pain syndrome (pain on the outside of the hip). It may help if you've had hip pain for at least 3 months and haven't had recent injections or other conservative treatments.
Ankara, YenimahalleAges 18–80 - NCT07750288Recruiting
Understanding breathing difficulty in children with lung injury
This study looks at how severe breathing difficulty (dyspnea) affects the recovery of children with a lung condition called acute respiratory distress syndrome (ARDS). It aims to improve care by tracking symptoms over time.
SantiagoAges 1 month–18 years - NCT07555171Enrolling by invitation
Brain Wave Changes During Fenfluramine Treatment in Lennox-Gastaut Syndrome
This study tracks how brain wave patterns change when children and young adults with Lennox-Gastaut Syndrome (a severe seizure disorder) take fenfluramine, a medication that helps reduce drop seizures. Researchers will use EEG (brain wave recordings) to understand how this treatment affects the brain.
Chicago, IllinoisAges 2–35 - NCT05374824Recruiting
Palliative surgery versus more seizure medicines for Lennox-Gastaut
This trial compares two treatment approaches for children with Lennox-Gastaut syndrome: palliative (comfort-focused) surgery versus adding more anti-seizure medicines. It aims to see which option works better for seizure control and day-to-day well-being.
Chicago, IllinoisAges Up to 26 years - NCT05002478Recruiting
Prone positioning for very sick babies with lung distress
This trial tests whether turning very sick, ventilated infants onto their stomach (prone positioning) can improve breathing when they have severe lung distress from likely pneumonia or bronchiolitis. It may help your baby get better oxygen levels and recover faster, while doctors closely monitor safety.
ViennaAges Up to 1 year - NCT06421506Recruiting
Giving surfactant through a thin tube in late preterm babies
This trial tests a less invasive way to give surfactant (a lung treatment) to babies born a few weeks early who need breathing help. It aims to see if this method works as well as standard care.
LondonAges 8 months–9 months
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,189 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.