Clinical trials
Down Syndrome clinical trials
Below are recruiting down syndrome clinical trials, each written for real people, not researchers. We’re tracking 3,055 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05283759Recruiting
Brugada syndrome registry study at UZ Brussel
This study keeps a registry (a secure list) of people who have been diagnosed with Brugada syndrome. It helps doctors learn about the condition over time and may support future research aimed at better care.
BrusselsAges 18–100 - NCT03659227Recruiting
Sample collection for serious drug skin reactions
This study collects skin and blood samples from adults who have a serious rash caused by medicines. The goal is to better understand these reactions and how to diagnose them sooner and more accurately.
CréteilAges 18 years+ - NCT05436587Recruiting
Genetic testing study for hard-to-classify bone marrow failure
This study looks for gene changes in families affected by rare inherited bone marrow failure that can cause fragile bones and fractures. It may help doctors understand the condition better by linking genetic mutations with family health patterns.
SohagAges Any age - NCT02329210Recruiting
Registry study for people with Bardet-Biedl syndrome
This study is a registry that collects health and genetic information from people with Bardet-Biedl syndrome. It may help researchers better understand the condition and improve future care by building a clear group of eligible patients.
Marshfield, WisconsinAges Any age - NCT03852407RecruitingPhase 2
Two kinds of conditioning before matched stem cell transplant
This trial compares two reduced-intensity conditioning regimens before you receive stem cells from a donor who matches your HLA type. It aims to find which approach works better and is safer for certain blood cancers.
AntwerpAges 18–75 - NCT05578105Recruiting
Study of autoimmune polyglandular disease genetics in Taiwan
This study looks at how common autoimmune polyglandular syndrome type II is in Taiwan and what genetic differences may be involved. It uses past hospital visit records and focuses on people who had a specific pattern of autoimmune conditions.
TaipeiAges 20 years+ - NCT01605266Recruiting
Study of insights in children with nephrotic syndrome
This study looks at children’s experiences and understanding of nephrotic syndrome using questionnaires. It aims to learn what helps families and children, which could improve care over time.
Brampton, OntarioAges 6 months–18 years - NCT05495776Recruiting
Study checks how often Lynch syndrome happens in colon cancer
This registry study looks at how many people with colon cancer also have Lynch syndrome, an inherited condition that can affect cancer risk. If you enroll, your care team collects basic information from your diagnosis to better estimate how common it is.
MoscowAges 18 years+ - NCT04709900Recruiting
Tests for stable chest pain using heart scans and pressure measurements
This trial studies how well different heart tests (imaging the blood flow and measuring blood pressure in the heart) work for people with stable chest pain. It may help guide safer, more accurate evaluation when you are not having a heart attack.
CopenhagenAges Any age - NCT05651204Recruiting
Study of brain GABA signals in Dravet syndrome
This study looks at “GABA signals” in the body/brain to learn more about Dravet syndrome and how it may relate to seizures. If you have Dravet syndrome caused by a specific SCN1A gene change, you may be asked to provide genetic test results and help with study visits so researchers can compare biomarker readings.
Fort Worth, TexasAges Up to 18 years - NCT05716880RecruitingPhase 3
Keto-like diet supplements for muscle loss in nephrotic syndrome
This Phase 3 study tests a keto-like supplement (Ketosteril) to help prevent or slow muscle loss in people with nephrotic syndrome. It may help by improving nutrition when the kidneys are leaking large amounts of protein.
Warsaw, Masovian DistrictAges 18 years+ - NCT05643092Recruiting
Testing scans and biomarkers for CAR T neurotoxicity risk
This study uses blood tests and brain imaging to better understand and predict nerve-system side effects that can happen after CAR T-cell treatment. It may help doctors spot people at higher risk sooner and guide safer care.
Shijiazhuang, HebeiAges 18–80 - NCT05767216Recruiting
Study of genetic and epigenetic differences in twin pairs with Down syndrome
This study looks at how genetics and gene-regulation (how genes turn on and off) differ between close family members who have different Down syndrome status. Researchers hope the findings will help explain why Down syndrome outcomes can vary even in very closely related people.
ParisAges 4–11 - NCT05772611Recruiting
Study of immune responses in brain autoimmune and nerve syndromes
This study looks at how the immune system works in certain neurological conditions, including autoimmune encephalitis and related nerve disorders. Researchers may use blood and/or spinal fluid samples, especially when antibodies are present or can’t be found, to better understand what’s driving the illness.
LyonAges 18 years+ - NCT03466463Recruiting
Gene therapy for severe Crigler-Najjar liver jaundice
This trial studies a gene therapy for people with severe Crigler-Najjar syndrome, a condition that causes high bilirubin (jaundice) due to a UGT1A1 gene change. It may help reduce the need for constant bilirubin-lowering treatment like phototherapy.
ClamartAges 9 years+ - NCT05797909Recruiting
PCOS Challenge Study: Share your experiences in a PCOS registry
This study asks people with PCOS (or PCOS-like symptoms) to join a registry and answer surveys. It helps researchers understand day-to-day experiences and needs in PCOS, which may lead to better support and care.
Bethesda, MarylandAges 12–80 - NCT05577845Recruiting
Ramosetron vs loperamide for bowel symptoms after rectal surgery
This trial compares two medicines—ramosetron and loperamide—to see which works better for severe bowel control problems after low anterior rectal surgery. It may help people with major LARS (low anterior resection syndrome) choose a safer, more effective treatment.
Seoul, Jongro-guAges 19 years+ - NCT04087421RecruitingPhase 3
Transanal irrigation vs glycerol suppositories for LARS
This trial compares two ways to help bowel control in people with low anterior resection syndrome (LARS) after low rectal surgery. It aims to see which option works better when standard treatments have not helped enough.
AarhusAges 18 years+ - NCT05857891Recruiting
Erythropoietin to help clear lung fluid in ARDS
This trial tests whether erythropoietin (EPO), a medicine that affects red blood cell production, can help clear extra fluid from the lungs in people with acute respiratory distress syndrome (ARDS). If it works, it could improve breathing and reduce lung fluid buildup during critical illness.
Wenzhou, ZhejiangAges 18 years+ - NCT04979078Recruiting
Light therapy to ease chemotherapy hand-foot skin reaction
This study tests whether a light-based therapy (photobiomodulation) can reduce pain and skin irritation from hand-foot syndrome/hand-foot skin reaction in people getting chemotherapy or targeted medicines. It may help you heal sooner and feel more comfortable while treatment continues.
Hasselt, LimburgAges 18 years+ - NCT05368168Recruiting
Early nerve stimulation to reduce rectal surgery after-effects
This trial tests whether starting a specific nerve stimulation treatment soon after rectal surgery can lower how often and how long a post-surgery bowel problem lasts. It may help patients recover with fewer symptoms after a low rectal anastomosis.
Vigo, PontevedraAges 18 years+ - NCT05965453Recruiting
Castor stent graft study for sudden type B aortic tears
This study looks at outcomes for people who had emergency (acute) type B aortic problems treated with a specific stent graft called the Castor single-branch device. It helps doctors understand how well this device works for selected patients and what factors affect results.
Xi'an, ShaanxiAges 18–95 - NCT05528900Recruiting
Study of children with acute food-triggered gut reactions
This study follows children (from birth to age 17) who have been diagnosed with acute food protein–induced enterocolitis syndrome (FPIES). Doctors want to better understand this condition after a suspected reaction to food, using either symptom-based diagnosis or a supervised food challenge when needed.
AngersAges Up to 17 years - NCT06058182Recruiting
Rna biomarkers for heart attack patients
This study looks at RNA markers in the blood of people having their first heart attack to see if they can predict recovery. If you are scheduled for a procedure to open blocked arteries, you may be able to join.
Milan, MilanAges 18 years+
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Common questions
- Are there clinical trials for down syndrome?
- Yes. Clin2 currently lists 3,055 recruiting down syndrome studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a down syndrome trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a down syndrome trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.